-
1
-
-
52449121246
-
Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?
-
Caligaris-Cappio F, Ghia P, (2008) Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 26: 4497-4503.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4497-4503
-
-
Caligaris-Cappio, F.1
Ghia, P.2
-
2
-
-
0030845707
-
The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors
-
Finger LR, Pu J, Wasserman R, Vibhakar R, Louie E, et al. (1997) The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 197: 177-187.
-
(1997)
Gene
, vol.197
, pp. 177-187
-
-
Finger, L.R.1
Pu, J.2
Wasserman, R.3
Vibhakar, R.4
Louie, E.5
-
3
-
-
16844381831
-
Mechanisms of B-cell lymphoma pathogenesis
-
Kuppers R, (2005) Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer 5: 251-262.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 251-262
-
-
Kuppers, R.1
-
4
-
-
0033567907
-
Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
-
Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK, (1999) Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 94: 1848-1854.
-
(1999)
Blood
, vol.94
, pp. 1848-1854
-
-
Hamblin, T.J.1
Davis, Z.2
Gardiner, A.3
Oscier, D.G.4
Stevenson, F.K.5
-
5
-
-
33846108722
-
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations
-
Stamatopoulos K, Belessi C, Moreno C, Boudjograh M, Guida G, et al. (2007) Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations. Blood 109: 259-270.
-
(2007)
Blood
, vol.109
, pp. 259-270
-
-
Stamatopoulos, K.1
Belessi, C.2
Moreno, C.3
Boudjograh, M.4
Guida, G.5
-
6
-
-
38949203770
-
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
-
Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, et al. (2008) Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 111: 1524-1533.
-
(2008)
Blood
, vol.111
, pp. 1524-1533
-
-
Murray, F.1
Darzentas, N.2
Hadzidimitriou, A.3
Tobin, G.4
Boudjogra, M.5
-
7
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192: 1027-1034.
-
(2000)
J Exp Med
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
Long, A.J.2
Iwai, Y.3
Bourque, K.4
Chernova, T.5
-
8
-
-
33745197352
-
Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro
-
Blank C, Kuball J, Voelkl S, Wiendl H, Becker B, et al. (2006) Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro. Int J Cancer 119: 317-327.
-
(2006)
Int J Cancer
, vol.119
, pp. 317-327
-
-
Blank, C.1
Kuball, J.2
Voelkl, S.3
Wiendl, H.4
Becker, B.5
-
9
-
-
5844264920
-
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
-
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2: 261-268.
-
(2001)
Nat Immunol
, vol.2
, pp. 261-268
-
-
Latchman, Y.1
Wood, C.R.2
Chernova, T.3
Chaudhary, D.4
Borde, M.5
-
10
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, et al. (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 8: 793-800.
-
(2002)
Nat Med
, vol.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
Tamura, H.4
Hirano, F.5
-
11
-
-
0037126021
-
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
-
Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 99: 12293-12297.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12293-12297
-
-
Iwai, Y.1
Ishida, M.2
Tanaka, Y.3
Okazaki, T.4
Honjo, T.5
-
12
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
Keir ME, Butte MJ, Freeman GJ, Sharpe AH, (2008) PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 26: 677-704.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
13
-
-
4444317516
-
PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
-
Sheppard KA, Fitz LJ, Lee JM, Benander C, George JA, et al. (2004) PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett 574: 37-41.
-
(2004)
FEBS Lett
, vol.574
, pp. 37-41
-
-
Sheppard, K.A.1
Fitz, L.J.2
Lee, J.M.3
Benander, C.4
George, J.A.5
-
14
-
-
70349561448
-
PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
-
Zhang L, Gajewski TF, Kline J, (2009) PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood 114: 1545-1552.
-
(2009)
Blood
, vol.114
, pp. 1545-1552
-
-
Zhang, L.1
Gajewski, T.F.2
Kline, J.3
-
15
-
-
0038796692
-
B7-H1 pathway and its role in the evasion of tumor immunity
-
Dong H, Chen L, (2003) B7-H1 pathway and its role in the evasion of tumor immunity. J Mol Med (Berl) 81: 281-287.
-
(2003)
J Mol Med (Berl)
, vol.81
, pp. 281-287
-
-
Dong, H.1
Chen, L.2
-
16
-
-
0030005099
-
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
-
Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubata T, et al. (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol 8: 765-772.
-
(1996)
Int Immunol
, vol.8
, pp. 765-772
-
-
Agata, Y.1
Kawasaki, A.2
Nishimura, H.3
Ishida, Y.4
Tsubata, T.5
-
17
-
-
36148992239
-
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
-
Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, et al. (2007) CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 110: 3352-3359.
-
(2007)
Blood
, vol.110
, pp. 3352-3359
-
-
Damle, R.N.1
Temburni, S.2
Calissano, C.3
Yancopoulos, S.4
Banapour, T.5
-
18
-
-
0034727833
-
Genomic aberrations and survival in chronic lymphocytic leukemia
-
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, et al. (2000) Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 343: 1910-1916.
-
(2000)
N Engl J Med
, vol.343
, pp. 1910-1916
-
-
Dohner, H.1
Stilgenbauer, S.2
Benner, A.3
Leupolt, E.4
Krober, A.5
-
19
-
-
33746877544
-
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma
-
Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ, (2006) Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Am J Surg Pathol 30: 802-810.
-
(2006)
Am J Surg Pathol
, vol.30
, pp. 802-810
-
-
Dorfman, D.M.1
Brown, J.A.2
Shahsafaei, A.3
Freeman, G.J.4
-
20
-
-
33646422454
-
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
-
Yang ZZ, Novak AJ, Stenson MJ, Witzig TE, Ansell SM, (2006) Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. Blood 107: 3639-3646.
-
(2006)
Blood
, vol.107
, pp. 3639-3646
-
-
Yang, Z.Z.1
Novak, A.J.2
Stenson, M.J.3
Witzig, T.E.4
Ansell, S.M.5
-
21
-
-
36248965162
-
Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma
-
Shimauchi T, Kabashima K, Nakashima D, Sugita K, Yamada Y, et al. (2007) Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma. Int J Cancer 121: 2585-2590.
-
(2007)
Int J Cancer
, vol.121
, pp. 2585-2590
-
-
Shimauchi, T.1
Kabashima, K.2
Nakashima, D.3
Sugita, K.4
Yamada, Y.5
-
22
-
-
42449147063
-
PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
-
Yamamoto R, Nishikori M, Kitawaki T, Sakai T, Hishizawa M, et al. (2008) PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood 111: 3220-3224.
-
(2008)
Blood
, vol.111
, pp. 3220-3224
-
-
Yamamoto, R.1
Nishikori, M.2
Kitawaki, T.3
Sakai, T.4
Hishizawa, M.5
-
23
-
-
35748959075
-
Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma
-
Roncador G, Garcia Verdes-Montenegro JF, Tedoldi S, Paterson JC, Klapper W, et al. (2007) Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. Haematologica 92: 1059-1066.
-
(2007)
Haematologica
, vol.92
, pp. 1059-1066
-
-
Roncador, G.1
Garcia Verdes-Montenegro, J.F.2
Tedoldi, S.3
Paterson, J.C.4
Klapper, W.5
-
24
-
-
45049087313
-
Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia
-
Xerri L, Chetaille B, Serriari N, Attias C, Guillaume Y, et al. (2008) Programmed death 1 is a marker of angioimmunoblastic T-cell lymphoma and B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. Hum Pathol 39: 1050-1058.
-
(2008)
Hum Pathol
, vol.39
, pp. 1050-1058
-
-
Xerri, L.1
Chetaille, B.2
Serriari, N.3
Attias, C.4
Guillaume, Y.5
-
25
-
-
0037307930
-
Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
-
Brown JA, Dorfman DM, Ma FR, Sullivan EL, Munoz O, et al. (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 170: 1257-1266.
-
(2003)
J Immunol
, vol.170
, pp. 1257-1266
-
-
Brown, J.A.1
Dorfman, D.M.2
Ma, F.R.3
Sullivan, E.L.4
Munoz, O.5
-
26
-
-
79952984773
-
Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma
-
Richendollar BG, Pohlman B, Elson P, Hsi ED, (2011) Follicular programmed death 1-positive lymphocytes in the tumor microenvironment are an independent prognostic factor in follicular lymphoma. Hum Pathol 42: 552-557.
-
(2011)
Hum Pathol
, vol.42
, pp. 552-557
-
-
Richendollar, B.G.1
Pohlman, B.2
Elson, P.3
Hsi, E.D.4
-
27
-
-
27744560614
-
Alternative splice variants of the human PD-1 gene
-
Nielsen C, Ohm-Laursen L, Barington T, Husby S, Lillevang ST, (2005) Alternative splice variants of the human PD-1 gene. Cell Immunol 235: 109-116.
-
(2005)
Cell Immunol
, vol.235
, pp. 109-116
-
-
Nielsen, C.1
Ohm-Laursen, L.2
Barington, T.3
Husby, S.4
Lillevang, S.T.5
-
28
-
-
16444367280
-
Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain
-
He XH, Xu LH, Liu Y, (2005) Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. Acta Pharmacol Sin 26: 462-468.
-
(2005)
Acta Pharmacol Sin
, vol.26
, pp. 462-468
-
-
He, X.H.1
Xu, L.H.2
Liu, Y.3
-
29
-
-
33845394662
-
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis
-
Wan B, Nie H, Liu A, Feng G, He D, et al. (2006) Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis. J Immunol 177: 8844-8850.
-
(2006)
J Immunol
, vol.177
, pp. 8844-8850
-
-
Wan, B.1
Nie, H.2
Liu, A.3
Feng, G.4
He, D.5
-
30
-
-
3142688997
-
SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation
-
Chemnitz JM, Parry RV, Nichols KE, June CH, Riley JL, (2004) SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J Immunol 173: 945-954.
-
(2004)
J Immunol
, vol.173
, pp. 945-954
-
-
Chemnitz, J.M.1
Parry, R.V.2
Nichols, K.E.3
June, C.H.4
Riley, J.L.5
-
31
-
-
0036624881
-
B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes
-
Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, et al. (2002) B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 99: 4087-4093.
-
(2002)
Blood
, vol.99
, pp. 4087-4093
-
-
Damle, R.N.1
Ghiotto, F.2
Valetto, A.3
Albesiano, E.4
Fais, F.5
-
32
-
-
10744222814
-
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
-
Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, et al. (2003) ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 101: 4944-4951.
-
(2003)
Blood
, vol.101
, pp. 4944-4951
-
-
Wiestner, A.1
Rosenwald, A.2
Barry, T.S.3
Wright, G.4
Davis, R.E.5
-
33
-
-
0035923535
-
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
-
Okazaki T, Maeda A, Nishimura H, Kurosaki T, Honjo T, (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc Natl Acad Sci U S A 98: 13866-13871.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13866-13871
-
-
Okazaki, T.1
Maeda, A.2
Nishimura, H.3
Kurosaki, T.4
Honjo, T.5
-
34
-
-
34247884612
-
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
-
Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ, (2007) The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol 8: 239-245.
-
(2007)
Nat Immunol
, vol.8
, pp. 239-245
-
-
Sharpe, A.H.1
Wherry, E.J.2
Ahmed, R.3
Freeman, G.J.4
-
35
-
-
63049113299
-
High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
-
Carreras J, Lopez-Guillermo A, Roncador G, Villamor N, Colomo L, et al. (2009) High numbers of tumor-infiltrating programmed cell death 1-positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma. J Clin Oncol 27: 1470-1476.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1470-1476
-
-
Carreras, J.1
Lopez-Guillermo, A.2
Roncador, G.3
Villamor, N.4
Colomo, L.5
-
36
-
-
13844294372
-
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
-
Iwai Y, Terawaki S, Honjo T, (2005) PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells. Int Immunol 17: 133-144.
-
(2005)
Int Immunol
, vol.17
, pp. 133-144
-
-
Iwai, Y.1
Terawaki, S.2
Honjo, T.3
-
37
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H, Dong H, Wang S, et al. (2005) Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res 65: 1089-1096.
-
(2005)
Cancer Res
, vol.65
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
Dong, H.4
Wang, S.5
-
38
-
-
32544459770
-
Restoring function in exhausted CD8 T cells during chronic viral infection
-
Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, et al. (2006) Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
-
(2006)
Nature
, vol.439
, pp. 682-687
-
-
Barber, D.L.1
Wherry, E.J.2
Masopust, D.3
Zhu, B.4
Allison, J.P.5
-
39
-
-
49649114804
-
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, et al. (2008) Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 14: 3044-3051.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
Landes, S.4
Kneller, A.5
-
40
-
-
54549110000
-
Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia
-
Giannopoulos K, Schmitt M, Kowal M, Wlasiuk P, Bojarska-Junak A, et al. (2008) Characterization of regulatory T cells in patients with B-cell chronic lymphocytic leukemia. Oncol Rep 20: 677-682.
-
(2008)
Oncol Rep
, vol.20
, pp. 677-682
-
-
Giannopoulos, K.1
Schmitt, M.2
Kowal, M.3
Wlasiuk, P.4
Bojarska-Junak, A.5
|