What is the role of renin inhibition during rat septic conditions: Preventive effect of aliskiren on sepsis-induced lung injury

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 10, 2014, Pages 969-978

  Akpinar, Erol ^a   Halici, Zekai ^a   Cadirci, Elif ^b   Bayir, Yasin ^b   Karakus, Emre ^b   Calik, Muhammet ^a   Topcu, Atilla ^a   Polat, Beyzagul ^b  

^a ATATURK UNIVERSITY   (Turkey)

^b ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Aliskiren; Angiotensin II; Cytokines; Lung injury; Oxidative stress; Sepsis

Indexed keywords

ALISKIREN; AMIDE; ANGIOTENSIN II; FUMARIC ACID DERIVATIVE; GLUTATHIONE; RENIN;

ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; COMPLICATION; DRUG EFFECTS; LIPID PEROXIDATION; LUNG INJURY; MALE; OXIDATIVE STRESS; PHYSIOLOGY; RAT; SEPSIS; TREATMENT OUTCOME; WISTAR RAT;

AMIDES; ANGIOTENSIN II; ANIMALS; FUMARATES; GLUTATHIONE; LIPID PEROXIDATION; LUNG INJURY; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RENIN; SEPSIS; TREATMENT OUTCOME;

EID: 84930919638     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-014-1014-0     Document Type: Article

References (52)

1. Adembri C, Kastamoniti E, Bertolozzi I, Vanni S, Dorigo W, Coppo M, Pratesi C, De Gaudio AR, Gensini GF, Modesti PA (2004) Pulmonary injury follows systemic inflammatory reaction in infrarenal aortic surgery. Crit Care Med 32:1170-1177
2. Albayrak A, Halici Z, Cadirci E, Polat B, Karakus E, Bayir Y, Unal D, Atasoy M, Dogrul A (2013a) Inflammation and peripheral 5-HT7 receptors: the role of 5-HT7 receptors in carrageenan induced inflammation in rats. Eur J Pharmacol 715:270-279
3. Albayrak A, Halici Z, Polat B, Karakus E, Cadirci E, Bayir Y, Kunak S, Karcioglu SS, Yigit S, Unal D, Atamanalp SS (2013b) Protective effects of lithium: a new look at an old drug with potential antioxidative and anti-inflammatory effects in an animal model of sepsis. Int Immunopharmacol 16:35-40
4. Ayala A, Lomas JL, Grutkoski PS, Chung CS (2003) Pathological aspects of apoptosis in severe sepsis and shock? Int J Biochem Cell Biol 35:7-15
5. Azizi M, Webb R, Nussberger J, Hollenberg NK (2006) Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 24:243-256
6. Basile DP, Leonard EC, Beal AG, Schleuter D, Friedrich J (2012) Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity. Am J Physiol Ren Physiol 302:F1494-F1502
7. Bechara RI, Pelaez A, Palacio A, Joshi PC, Hart CM, Brown LA, Raynor R, Guidot DM (2005) Angiotensin II mediates glutathione depletion, transforming growth factor-beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung. Am J Physiol Lung Cell Mol Physiol 289:L363-L370
8. Boldt J, Papsdorf M, Kumle B, Piper S, Hempelmann G (1998) Influence of angiotensin-converting enzyme inhibitor enalapril at on endothelial-derived substances in the critically ill. Crit Care Med 26:1663-1670
9. Bone RC, Grodzin CJ, Balk RA (1997) Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 112:235-243
10. Bucher M, Ittner KP, Hobbhahn J, Taeger K, Kurtz A (2001) Downregulation of angiotensin II type 1 receptors during sepsis. Hypertension 38:177-182
11. Cadirci E, Altunkaynak BZ, Halici Z, Odabasoglu F, Uyanik MH, Gundogdu C, Suleyman H, Halici M, Albayrak M, Unal B (2010) Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats. Shock 33:479-484
12. Cadirci E, Halici Z, Bayir Y, Albayrak A, Karakus E, Polat B, Unal D, Atamanalp SS, Aksak S, Gundogdu C (2013) Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats. Immunobiology 218:1271-1283
13. Choi DE, Jeong JY, Lim BJ, Chang YK, Na KR, Shin YT, Lee KW (2011) Aliskiren ameliorates renal inflammation and fibrosis induced by unilateral ureteral obstruction in mice. J Urol 186:694-701
14. Coskun AK, Yigiter M, Oral A, Odabasoglu F, Halici Z, Mentes O, Cadirci E, Atalay F, Suleyman H (2011) The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis. Sci World J 11:1341-1356
15. Damas P, Ledoux D, Nys M, Vrindts Y, De Groote D, Franchimont P, Lamy M (1992) Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 215:356-362
16. Dielis AW, Smid M, Spronk HM, Houben AJ, Hamulyak K, Kroon AA, Ten Cate H, de Leeuw PW (2007) Changes in fibrinolytic activity after angiotensin II receptor blockade in therapy-resistant hypertensive patients. J Thromb Haemost 5:1509-1515
17. Force ADT, Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS (2012) Acute respiratory distress syndrome: the Berlin Definition. J Am Med Assoc 307:2526-2533
18. Hagiwara S, Iwasaka H, Hidaka S, Hasegawa A, Koga H, Noguchi T (2009a) Antagonist of the type-1 ANG II receptor prevents against LPS-induced septic shock in rats. Intensive Care Med 35:1471-1478
19. Hagiwara S, Iwasaka H, Matumoto S, Hidaka S, Noguchi T (2009b) Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models. Crit Care Med 37:626-633
20. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, Penninger JM (2005) Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 436:112-116
21. Laesser M, Oi Y, Ewert S, Fandriks L, Aneman A (2004) The angiotensin II receptor blocker candesartan improves survival and mesenteric perfusion in an acute porcine endotoxin model. Acta Anaesthesiol Scand 48:198-204
22. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408
23. Lund DD, Brooks RM, Faraci FM, Heistad DD (2007) Role of angiotensin II in endothelial dysfunction induced by lipopolysaccharide in mice. Am J Physiol Heart Circ Physiol 293:H3726-H3731
24. Marques Silva S, Carneiro FP, Ferreira VM, de Oliveira PG, de Sousa JB (2013) Effects of metoclopramide on healing of colonic anastomoses in a rat model of abdominal sepsis metoclopramide and healing of colonic anastomoses. J Investig Surg Off J Acad Surg Res
25. Marshall RP, Webb S, Bellingan GJ, Montgomery HE, Chaudhari B, McAnulty RJ, Humphries SE, Hill MR, Laurent GJ (2002) Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care 166:646-650
26. Martin GS, Mannino DM, Eaton S, Moss M (2003) The epidemiology of sepsis in the United States from 1979 through 2000. New Engl J Med 348:1546-1554
27. Mehta PK, Griendling KK (2007) Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 292:C82-C97
28. Miyoshi M, Nagata K, Imoto T, Goto O, Ishida A, Watanabe T (2003) ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats. Am J Physiol Regul Integr Comp Physiol 284:R1092-R1097
29. Nangaku M, Inagi R, Miyata T, Fujita T (2007) Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation. Adv Exp Med Biol 618:85-99
30. Nitescu N, Grimberg E, Guron G (2008) Low-dose candesartan improves renal blood flow and kidney oxygen tension in rats with endotoxin-induced acute kidney dysfunction. Shock 30:166-172
31. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358
32. Polat B, Cadirci E, Halici Z, Bayir Y, Unal D, Bilgin BC, Yuksel TN, Vancelik S (2013) The protective effect of amiodarone in lung tissue of cecal ligation and puncture-induced septic rats: a perspective from inflammatory cytokine release and oxidative stress. Naunyn Schmiedeberg's Arch Pharmacol 386:635-643
33. Rashikh A, Ahmad SJ, Pillai KK, Kohli K, Najmi AK (2012) Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy. Biomed Pharmacother 66:138-143
34. Rashikh A, Pillai KK, Ahmad SJ, Akhtar M, Najmi AK (2013) Aliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury. J Renin-Angiotensin-Aldosterone Syst 14:14-22
35. Ritter C, Andrades M, Frota Junior ML, Bonatto F, Pinho RA, Polydoro M, Klamt F, Pinheiro CT, Menna-Barreto SS, Moreira JC, Dal-Pizzol F (2003) Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation. Intensive Care Med 29:1782-1789
36. Rolih CA, Ober KP (1995) The endocrine response to critical illness. Med Clin N Am 79:211-224
37. Ruiz-Ortega M, Ruperez M, Lorenzo O, Esteban V, Blanco J, Mezzano S, Egido J (2002) Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney Int Suppl: S12-22
38. Salgado DR, Rocco JR, Silva E, Vincent JL (2010) Modulation of the renin-angiotensin-aldosterone system in sepsis: a new therapeutic approach? Expert Opin Ther Targets 14:11-20
39. Salvemini D, Wang ZQ, Bourdon DM, Stern MK, Currie MG, Manning PT (1996) Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur J Pharmacol 303:217-220
40. Schrier RW, Wang W (2004) Acute renal failure and sepsis. N Engl J Med 351:159-169
41. Sedlak J, Lindsay RH (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem 25:192-205
42. Sen S, Sabirli S, Ozyigit T, Uresin Y (2013) Aliskiren: review of efficacy and safety data with focus on past and recent clinical trials. Ther Adv Chron Dis 4:232-241
43. Shen L, Mo H, Cai L, Kong T, Zheng W, Ye J, Qi J, Xiao Z (2009) Losartan prevents sepsis-induced acute lung injury and decreases activation of nuclear factor kappaB and mitogen-activated protein kinases. Shock 31:500-506
44. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497-500
45. Touyz RM (2005) Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotensin II. Curr Opin Nephrol Hypertens 14:125-131
46. Wang Z, Liu Y, Han Y, Guan W, Kou X, Fu J, Yang D, Ren H, He D, Zhou L, Zeng C (2013) Protective effects of aliskiren on ischemia-reperfusion-induced renal injury in rats. Eur J Pharmacol 718:160-166
47. Wilkinson IB, Franklin SS, Cockcroft JR (2004) Nitric oxide and the regulation of large artery stiffness: from physiology to pharmacology. Hypertension 44:112-116
48. Wood JM, Maibaum J, Rahuel J, Grutter MG, Cohen NC, Rasetti V, Ruger H, Goschke R, Stutz S, Fuhrer W, Schilling W, Rigollier P, Yamaguchi Y, Cumin F, Baum HP, Schnell CR, Herold P, Mah R, Jensen C, O'Brien E, Stanton A, Bedigian MP (2003) Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 308:698-705
49. Yao SL, Feng D, Wu QP, Li KZ, Wang LK (2008) Losartan attenuates ventilator-induced lung injury. J Surg Res 145:25-32
50. Yigiter M, Halici Z, Odabasoglu F, Keles ON, Atalay F, Unal B, Salman AB (2011) Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. Eur J Obstet Gynecol Reprod Biol 157:94-100
51. Zanotti S, Kumar A, Kumar A (2002) Cytokine modulation in sepsis and septic shock. Expert Opin Investig Drugs 11:1061-1075
52. Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, Chen Q, Ferro A, Ji Y (2014) Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J Am Heart Assoc 3:e000606