Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats.

Journal of the American Heart Association

Volumn 3, Issue 1, 2014, Pages

  Zhang, Wen ^a   Han, Y ^b   Meng, Guoliang ^b   Bai, Wenli ^b   Xie, Liping ^b   Lu, Hui ^b   Shao, Yongfeng ^b   Wei, Lei ^b   Pan, Shiyang ^b   Zhou, Suming ^b   Chen, Q ^b   Ferro, Albert ^b   Ji, Yong ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; AMIDE; ANTIHYPERTENSIVE AGENT; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FUMARIC ACID DERIVATIVE; GELATINASE A; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; MMP2 PROTEIN, RAT; MMP9 PROTEIN, RAT; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; NOS3 PROTEIN, RAT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; RENIN; SUPEROXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 1 PROTEIN, RAT; TISSUE INHIBITOR OF METALLOPROTEINASE-1 PROTEIN, RAT;

ANIMAL; ARTICLE; BLOOD PRESSURE; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; HEART CONTRACTION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART STROKE VOLUME; HYPERTENSION; ISCHEMIA; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; RAT; REPERFUSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; WISTAR KYOTO RAT;

ALISKIREN; ISCHEMIA; MYOCARDIAL INFARCTION; NITRIC OXIDE SYNTHASE; REPERFUSION;

AMIDES; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FUMARATES; HYPERTENSION; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RENIN; SIGNAL TRANSDUCTION; STROKE VOLUME; SUPEROXIDES; TISSUE INHIBITOR OF METALLOPROTEINASE-1; VENTRICULAR FUNCTION, LEFT;

EID: 84898642452     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.113.000606     Document Type: Article

References (0)