Usefulness of fibrin degradation products and d-dimer levels as biomarkers that reflect the severity of trauma

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 5, 2013, Pages 1275-1278

  Hagiwara, Shuichi ^a,b   Oshima, Kiyohiro ^a,b   Aoki, Makoto ^a,b   Murata, Masato ^a,b   Ishihara, Koichi ^a   Kaneko, Minoru ^a,b   Furukawa, Kazumi ^a,b   Nakamura, Takuro ^a,b   Ohyama, Yoshio ^b   Tamura, Jun'Ichi ^b  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

biomarker; d dimer; fibrin degradation products (FDPs); Injury Severity Score (ISS); trauma

Indexed keywords

D DIMER; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; HEMOGLOBIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; EMERGENCY WARD; ERYTHROCYTE TRANSFUSION; HEART RATE; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INJURY SCALE; INJURY SEVERITY; INTERNATIONAL NORMALIZED RATIO; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MEDICAL RECORD REVIEW; MORTALITY; PARTIAL THROMBOPLASTIN TIME; PATIENT TRANSPORT; PRIORITY JOURNAL; PROTHROMBIN TIME; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; THROMBOCYTE COUNT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD PRESSURE; CHILD; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HEART RATE; HEMATOCRIT; HEMOGLOBINS; HUMANS; INJURY SEVERITY SCORE; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; RETROSPECTIVE STUDIES; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84877043936     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31828cc967     Document Type: Article

References (18)

1. Tian HL, Chen H, Wu BS, et al. D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: analysis of 194 cases. Neurosurg Rev. 2010;33:359-366.
2. Kuo JR, Lin KC, Lu CL, et al. Correlation of a high d-dimer level with poor outcome in traumatic intracranial hemorrhage. Eur J Neurol. 2007; 14:1073-1078.
3. Swanson CA, Burns JC, Peterson BM. Low plasma d-dimer concentration predicts the absence of traumatic brain injury in children. J Trauma. 2010;68:1072-1077.
4. Kearney TJ, Bentt L, Grode M, et al. Coagulopaty and catecholamine in severe head injury. J Trauma. 1992;32:608-611.
5. Baker SP, O'Neill B, Haddon W Jr, et al. The Injury Severity Score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974;14:187-196.
6. Sie P. The value of laboratory tests in the diagnosis of venous thromboembolism. Haematolgica. 1995;80(suppl 2):57-60.
7. The DVTENOX Study Group. Markers of haemostatic system activation in acute deep venous thrombosis evolution during the first days of heparin treatment. Thromb Haemast. 1993;70:909-914.
8. Perrier A, Desmarais S, Miron MJ, et al. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet. 1999;353:190-195.
9. Owings JT, Gosselin RC, Anderson JT, et al. Practical utility of d-dimer assay for excluding thromboembolism in severity injured trauma patients. J Trauma. 2001;51:425-430.
10. Sawamura A, Hayakawa M, Gando S, et al. Disseminated intravascular coagulation with a fibrinolytic phenotype at an early phase of trauma predicts mortality. Thromb Res. 2009;124:608-613.
11. Perez A, Abbet P, Drescher MJ. D-dimers in the emergency department evaluation of aortic dissection. ACAD Emerg Med. 2004;11:397-400.
12. Hayakawa M, Wada T, Sugano M, et al. The relationship between high level of FDP (fibrin/fibrinogen degradation products) on the admission and massive bleeding in patients with blunt trauma. J Jpn Assoc Acute Med. 2010;21:165-171 (in Japanese with English abstract).
13. Sørensen JV, Jensen HP, Rahr HB, et al. Fibrinogen and fibrin derivatives in traumatized patients: relation to injury severity and posttraumatic pulmonary dysfunction. Haemostasis. 1993;23:91-97.
14. Chen JP, Rowe DW, Enderson BL. Contrasting post-traumatic serial changes for d-dimer and PAI-1 in critically injured patients. Thromb Res. 1999;94:175-185.
15. Zhu YJ, Huang XK. Relationship between disseminated intravascular coagulation and levels of plasma thrombinogen segment 1+2, d-dimer, and thrombomodulin in patients with multiple injuries. Chin J Traumatol. 2009; 12:203-209.
16. Rizoli S, Nascimento B, Key N, et al. Disseminated intravascular coagulopathy in the first 24 hours after trauma: the association between ISTH score and anatomopathologic evidence. J Trauma. 2011;71:S441-S447.
17. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British committee for standards in haematology. Br J Haematol. 2009;145:24-33.
18. Adam SS, Key NS, Greenberg CS. D-dimer antigen: current concepts and future prospects. Blood. 2009;113:2878-2887.