Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

Journal of Controlled Release

Volumn 182, Issue 1, 2014, Pages 22-32

  Kinnunen, Hanne M ^a   Mrsny, Randall J ^a  

^a University of Bath   (United Kingdom)

Author keywords

Biopharmaceuticals; Formulation; Subcutaneous injection

Indexed keywords

BIOCHEMISTRY; BLOOD VESSELS; CHEMICAL STABILITY; CONTROLLED DRUG DELIVERY; MICROCIRCULATION; PEPTIDES; TARGETED DRUG DELIVERY;

BIOPHARMACEUTICALS; FORMULATION; FORMULATION DEVELOPMENT; PHYSIOLOGICAL ENVIRONMENT; PHYSIOLOGICAL PROPERTIES; SUBCUTANEOUS ROUTE; SUBCUTANEOUS TISSUES; THERAPEUTIC OUTCOMES;

TISSUE;

CHONDROITIN SULFATE; COLLAGEN; HYALURONIC ACID; PEPTIDE; PROTEIN; DRUG;

ARTICLE; CAPILLARY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENVIRONMENTAL STRESS; EXTRACELLULAR MATRIX; HUMAN; HYDROSTATIC PRESSURE; INJECTION SITE; INTERSTITIAL FLUID; NONHUMAN; ONCOTIC PRESSURE; OSMOTIC PRESSURE; PH; PRIORITY JOURNAL; PROTEIN STABILITY; STATIC ELECTRICITY; SUBCUTANEOUS TISSUE; TEMPERATURE; ANIMAL; CHEMISTRY; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; SKIN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; HUMANS; INJECTIONS, SUBCUTANEOUS; PEPTIDES; PHARMACEUTICAL PREPARATIONS; PROTEIN STABILITY; PROTEINS; SKIN; SKIN PHYSIOLOGICAL PHENOMENA;

EID: 84897831277     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.011     Document Type: Review

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