Role of Klotho, an antiaging protein, in pulmonary fibrosis

Archives of Toxicology

Volumn 89, Issue 5, 2015, Pages 785-795

  Shin, In Sik ^a,b   Shin, Hyeun Kyoo ^a   Kim, Jong Choon ^b   Lee, Mee Young ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Chronic asthma; Klotho; Pulmonary fibrosis; Smad3; Transforming growth factor; Vascular endothelial growth factor

Indexed keywords

BETA GLUCURONIDASE; KLOTHO PROTEIN; OVALBUMIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A;

ANIMAL; ASTHMA; BAGG ALBINO MOUSE; BRONCHUS; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; FEMALE; HUMAN; LUNG FIBROSIS; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION;

ANIMALS; ASTHMA; BRONCHI; DISEASE MODELS, ANIMAL; FEMALE; GLUCURONIDASE; HUMANS; MICE; MICE, INBRED BALB C; OVALBUMIN; PULMONARY FIBROSIS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84930884493     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1282-y     Document Type: Article

References (36)

1. Camilli TC, Xu M, O’Connell MP, Chien B, Frank BP, Subaran S, Indig FE, Morin PJ, Hewitt SM, Weeraratna AT (2011) Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res 24:175–186
2. Chen B, Wang X, Zhao W, Wu J (2010) Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549. J Exp Clin Cancer Res 29:99
3. Chetta A, Zanini A, Foresi A, D’lppolito R, Tipa A, Castagnaro A, Baraldo S, Neri M, Saetta M, Olivieri D (2005) Vascular endothelial growth factor up-regulation and bronchial wall remodeling in asthma. Clin Exp Allergy 35:1437–1442
4. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M (2011) Klotho inhibits transforming growth factor-beta1(TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286:8655–8665
5. Foley SC, Mogas AK, Olivenstein R, Fiset PO, Chakir J, Bourbeau J, Emst P, Lemere C, Martin JG, Hamid Q (2007) Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol 199:863–871
6. Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Maruoka S, Horie T (2001) Transforming growth factor-β1 induces phenotypic modulation of human lung fibroblasts to myofibroblast through a c-jun-NH2-terminal kinase-dependent pathway. Am J Respir Crit Care Med 163:356–363
7. Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J (2010) The ASK1-signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging 2:597–611
8. Kazi A, Lotfi SS, Goncharova EA, Tliba O, Amrani Y, Krymskaya VP, Lazaar AL (2004) Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent. Am J Physiol Lung Cell Mol Physiol 286:539–545
9. Kohan M, Muro AF, Bader R, Berkman N (2011) The extra domain A of fibronection is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice. J Allergy Clin Immunol 127:439–446
10. Kuro-o M (2006) Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens 15:437–441
11. Kuro-o M (2009) Klotho and aging. Biochim Biophys Acta 1790:1049–1058
12. Kuro-o M (2010) Klotho. Pflugers Arch 459:333–343
13. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nabeshima YI (1997) Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 390:45–51
14. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829–1833
15. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA (2004) Vascular endothelial growth factor (VEGF) induces remodeling and enhances Th2-mediated sensitization and inflammation in the lung. Nat Med 10:1095–1103
16. Lee KS, Park SJ, Kim SR, Min KH, Lee KY, Choe YH, Hong SH, Lee YR, Kim JS, Hong SJ, Lee YC (2008) Inhibition of VEGF blocks TGF-β1 production through a PI3 K/Akt signaling pathway. Eur Respir J 31:523–531
17. Lee CG, Ma B, Takyar S, Ahangari F, Delacruz C, He CH, Elias JA (2011a) Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 8:512–515
18. Lee MY, Lee JA, Seo CS, Ha H, Lee NH, Shin HK (2011b) Protective effects of Mentha haplocalyx ethanol extract (MH) in a mouse model of allergic asthma. Phytother Res 25:863–869
19. Li ZD, Bork JP, Krueger B, Patsenker E, Schulze-Krebs A, Hahn EG, Schuppan D (2005) VEGF induces proliferation, migration, and TGF-beta1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Biochem Biophys Res Commun 334:1049–1060
20. Lin HY, Moustakas A (1994) TGF-beta receptors: structure and function. Cell Mol Biol 40:337–349
21. Moerno JA, Izquierdo MC, Sanchez-Nino MD, Suarez-Alvarez B, Lopez-Larrea C, Jakubowski A, Blanco J, Ramirez R, Selgas R, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB (2011) The inflammatory cytokines TWEAK and TNFα reduce renal Klotho expression through NFκB. J Am Soc Nephrol 22:1315–1325
22. Moustakas A, Heldin CH (2009) The regulation of TGF-beta signal transduction. Development 136:3699–3714
23. Phan SH (2002) The myofibroblast in pulmonary fibrosis. Chest 122:286–289
24. Qin W, Chung AC, Huang XR, Meng XM, Hui DS, Yu CM, Sung JJ, Lan HY (2011) TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol 22:1462–1474
25. Scotton CJ, Chambers RC (2007) Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132:1311–1321
26. Sheppard D (2006) Transforming growth factor beta: a central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 3:413–417
27. Sugiura H, Yoshida T, Shiohira S, Kohei J, Mitobe M, Kurosu H, Kuro-o M, Nitta K, Tsuchiya K (2012) Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis. Am J Physiol Renal Physiol 302:1252–1264
28. Thurston RD, Larmonier CB, Majewski PM, Ramalingam R, Midura-Kiela M, Laubitz D, Vandewalle A, Besselsen DG, Muhlbauer M, Jobin C, Kiela PR, Ghishan FK (2010) Tumor necrosis factor and inferferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology 138:1384–1394
29. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770–774
30. Usuki J, Matsuda K, Azuma A, Kudoh S, Gemma A (2012) Sequential analysis of myofibroblast differentiation and transforming growth factor-β1/Smad pathway activation in murine pulmonary fibrosis. J Nippon Med Sch 79:46–59
31. Vasquez-Pinto LM, Nantel F, Sirois P, Jancar S (2010) Bradykinin B(1) receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-beta and VEGF in a murine model of asthma. Neuropeptides 44:107–113
32. Wang Y, Sun Z (2009) Current understanding of klotho. Ageing Res Rev 8:43–51
33. Xiong YY, Wu FH, Wang JS, Li J, Kong LY (2012) Attenuation of airway hyperreactivity and T helper cell type 2 responses by coumarins from Peucedanum praeruptorum Dunn in a murine model of allergic airway inflammation. J Ethonopharmacol 141:314–321
34. Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP, Kuro-o M (2005) Regulation of oxidative stress by the anti-aging hormone Klotho. J Biol Chem 280:38029–38034
35. Zhang K, Rekhter MD, Gordon D, Phan SH (1994) Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study. Am J Pathol 145:114–125
36. Zhao Y, Banerjee S, Dey N, Lejeune WS, Sarkar PS, Brobey R, Rosenblatt KP, Tilton RG, Choudhary S (2011) Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 60:1907–1916