Phosphoinositide 3-kinase β, phosphoinositide 3-kinase δ, and phosphoinositide 3-kinase γ mediate the anti-inflammatory effects of magnesium sulfate

Journal of Surgical Research

Volumn 197, Issue 2, 2015, Pages 390-397

  Lee, Ping Ying ^a,b   Yang, Chen Hsien ^c,d   Kao, Ming Chang ^c,d   Su, Nuan Yen ^a   Tsai, Pei Shan ^e   Huang, Chun Jen ^c,d  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b NURSING AND MANAGEMENT COLLEGE   (Taiwan)

^c Taipei Tzu Chi Hospital   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chemokine; Cytokine; Endotoxin; Macrophages; MgSO4; NF B

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 2 (6 AMINO 9 PURINYLMETHYL) 5 METHYL 3 (2 METHYLPHENYL) 3H QUINAZOLIN 4 ONE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURFURYLIDENE] 2,4 THIAZOLIDINEDIONE; CALCIUM CHANNEL L TYPE; ENDOTOXIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; MAGNESIUM SULFATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE BETA; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; CHEMOKINE; CYTOKINE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME INHIBITION; FLUOROMETRY; IMMUNOFLUORESCENCE TEST; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; EVALUATION STUDY; MACROPHAGE ACTIVATION; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; CHEMOKINES; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; CYTOKINES; ENDOTOXINS; MACROPHAGE ACTIVATION; MACROPHAGES; MAGNESIUM SULFATE; MICE;

EID: 84930867896     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2015.04.051     Document Type: Article

References (32)

1. P.G. Prude, and R. Mittendorf Contemporary usage of obstetric magnesium sulfate: indication, contraindication, and relevance of dose Obstet Gynecol 114 2009 669
2. B.H. Rowe, and C.A. Camargo Jr. The role of magnesium sulfate in the acute and chronic management of asthma Curr Opin Pulm Med 14 2008 70
3. S. Brill, P.M. Sedgwick, W. Hamann, and P.P. Di Vadi Efficacy of intravenous magnesium in neuropathic pain Br J Anaesth 89 2002 711
4. C.Y. Lin, P.S. Tsai, Y.C. Hung, and C.J. Huang L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate Br J Anaesth 104 2010 44
5. B. Rochelson, O. Dowling, N. Schwartz, and C.N. Metz Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway J Reprod Immunol 73 2007 101
6. C.Y. Lee, W.C. Jan, P.S. Tsai, and C.J. Huang Magnesium sulfate mitigates acute lung injury in endotoxemia rats J Trauma 70 2011 1177
7. N.Y. Su, T.C. Peng, P.S. Tsai, and C.J. Huang Phosphoinositide 3-kinase/Akt pathway is involved in mediating the anti-inflammation effects of magnesium sulfate J Surg Res 185 2013 726
8. L.C. Cantley The phosphoinositide 3-kinase pathway Science 296 2002 1655
9. D.A. Fruman, and G. Bismuth Fine tuning the immune response with PI3K Immunol Rev 228 2009 253
10. M. Guha, and N. Mackman The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells J Biol Chem 277 2002 32124
11. G. Schabbauer, M. Tencati, B. Pedersen, R. Pawlinski, and N. Mackman PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice Arterioscler Thromb Vasc Biol 24 2004 1963
12. K. Okkenhaug Signaling by the phosphoinositide 3-kinase family in immune cells Annu Rev Immunol 31 2013 675
13. X.Q. Li, W. Cao, and T. Li Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway Int Immunopharmacol 9 2009 1032
14. E. Jones, I.M. Adcock, B.Y. Ahmed, and N.A. Punchard Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCepsilon and JAK2 in RAW macrophages J Inflamm (Lond) 4 2007 23
15. M. Degen, P. Barron, E. Natarajan, H.R. Widlund, and J.G. Rheinwald RSK activation of translation factor eIF4B drives abnormal increases of laminin γ2 and MYC protein during neoplastic progression to squamous cell carcinoma PLoS One 8 2013 e78979
16. E. Sapey, H. Greenwood, and G. Walton Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence Blood 123 2014 239
17. E. Bourdonnay, C.H. Serezani, D.M. Aronoff, and M. Peters-Golden Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2 J Leukoc Biol 92 2012 219
18. C.P. Chen, P.S. Tsai, and C.J. Huang Antiinflammation effect of human placental multipotent mesenchymal stromal cells is mediated by prostaglandin E2 via a myeloid differentiation primary response gene 88-dependent pathway Anesthesiology 117 2012 568
19. R.M. Paredes, J.C. Etzler, L.T. Watts, W. Zheng, and J.D. Lechleiter Chemical calcium indicators Methods 46 2008 143
20. L. Rodríguez-Borlado, D.F. Barber, and C. Hernández Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio J Immunol 170 2003 4475
21. W.P. Fung-Leung Phosphoinositide 3-kinase delta (PI3Kδ) in leukocyte signaling and function Cell Signal 23 2011 603
22. E. Hirsch, G. Lembo, G. Montrucchio, C. Rommel, C. Costa, and L. Barberis Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing Thromb Haemost 95 2006 29
23. E.L. Martin, D.G. Souza, and C.T. Fagundes Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment Am J Respir Crit Care Med 182 2010 762
24. M. Thomas, M.J. Edwards, and E. Sawicka Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation Immunology 126 2009 413
25. A. Tups, G.M. Anderson, and M. Rizwan Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus J Neuroendocrinol 22 2010 534
26. P. Liu, H. Cheng, and S. Santiago Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms Nat Med 17 2011 1116
27. S. Jamieson, J.U. Flanagan, and S. Kolekar A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types Biochem J 438 2011 53
28. L. So, S.S. Yea, and J.S. Oak Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function J Biol Chem 288 2013 5718
29. M.P. Gratacap, J. Guillermet-Guibert, and V. Martin Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions Adv Enzyme Regul 51 2011 106
30. M. Leinders, F.J. Koehrn, and B. Bartok Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain Pain 155 2014 1150
31. 2+ Am J Phys 271 1996 L251
32. 2+- and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages J Biol Chem 281 2006 31337