Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

Current Biology

Volumn 18, Issue 12, 2008, Pages 900-905

  Kruisselbrink, Evelien ^a   Guryev, Victor ^a   Brouwer, Karin ^a   Pontier, Daphne B ^a   Cuppen, Edwin ^a   Tijsterman, Marcel ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

CELLCYCLE; DNA

Indexed keywords

BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CAENORHABDITIS ELEGANS PROTEIN; DOG 1 PROTEIN, C ELEGANS; DOG-1 PROTEIN, C ELEGANS; FANCONI ANEMIA PROTEIN; GUANINE QUADRUPLEX; HELICASE;

ANIMAL; ARTICLE; CAENORHABDITIS ELEGANS; DNA MICROARRAY; DNA REPLICATION; DNA SEQUENCE; GENE DELETION; GENETICS; GENOMIC INSTABILITY; MUTATION; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA HELICASES; DNA REPLICATION; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; G-QUADRUPLEXES; GENOMIC INSTABILITY; MUTATION; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION;

ANIMALIA; CAENORHABDITIS ELEGANS; CANIS FAMILIARIS; MAMMALIA;

EID: 45449102827     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2008.05.013     Document Type: Article

References (26)

1. Harfe B.D., and Jinks-Robertson S. DNA mismatch repair and genetic instability. Annu. Rev. Genet. 34 (2000) 359-399
2. Brewer B.J., Lockshon D., and Fangman W.L. The arrest of replication forks in the rDNA of yeast occurs independently of transcription. Cell 71 (1992) 267-276
3. Lambert S., Watson A., Sheedy D.M., Martin B., and Carr A.M. Gross chromosomal rearrangements and elevated recombination at an inducible site-specific replication fork barrier. Cell 121 (2005) 689-702
4. Gellert M., Lipsett M.N., and Davies D.R. Helix formation by guanylic acid. Proc. Natl. Acad. Sci. USA 48 (1962) 2013-2018
5. Sen D., and Gilbert W. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature 334 (1988) 364-366
6. Cheung I., Schertzer M., Rose A., and Lansdorp P.M. Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat. Genet. 31 (2002) 405-409
7. Youds J.L., Barber L.J., Ward J.D., Collis S.J., O'Neil N.J., Boulton S.J., and Rose A.M. DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair. Mol. Cell. Biol. 28 (2008) 1470-1479
8. Levran O., Attwool C., Henry R.T., Milton K.L., Neveling K., Rio P., Batish S.D., Kalb R., Velleur E., Barral S., et al. The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat. Genet. 37 (2005) 931-933
9. Levitus M., Waisfisz O., Godthelp B.C., de Vries Y., Hussain S., Wiegant W.W., Elghalbzouri-Maghrani E., Steltenpool J., Rooimans M.A., Pals G., et al. The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J. Nat. Genet. 37 (2005) 934-935
10. Bridge W.L., Vandenberg C.J., Franklin R.J., and Hiom K. The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. Nat. Genet. 37 (2005) 953-957
11. Litman R., Peng M., Jin Z., Zhang F., Zhang J., Powell S., Andreassen P.R., and Cantor S.B. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell 8 (2005) 255-265
12. Abdurashidova G., Deganuto M., Klima R., Riva S., Biamonti G., Giacca M., and Falaschi A. Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science 287 (2000) 2023-2026
13. Tijsterman M., Pothof J., and Plasterk R.H. Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics 161 (2002) 651-660
14. Denver D.R., Feinberg S., Estes S., Thomas W.K., and Lynch M. Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans. Genetics 170 (2005) 107-113
15. Sia E.A., Kokoska R.J., Dominska M., Greenwell P., and Petes T.D. Microsatellite instability in yeast: dependence on repeat unit size and DNA mismatch repair genes. Mol. Cell. Biol. 17 (1997) 2851-2858
16. Youds J.L., O'Neil N.J., and Rose A.M. Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics 173 (2006) 697-708
17. Fry M., and Loeb L.A. Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n. J. Biol. Chem. 274 (1999) 12797-12802
18. Sun H., Karow J.K., Hickson I.D., and Maizels N. The Bloom's syndrome helicase unwinds G4 DNA. J. Biol. Chem. 273 (1998) 27587-27592
19. Burge S., Parkinson G.N., Hazel P., Todd A.K., and Neidle S. Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res. 34 (2006) 5402-5415
20. Maizels N. Dynamic roles for G4 DNA in the biology of eukaryotic cells. Nat. Struct. Mol. Biol. 13 (2006) 1055-1059
21. Gilbert D.M. Origins go plastic. Mol. Cell 20 (2005) 657-658
22. Niedernhofer L.J., Lalai A.S., and Hoeijmakers J.H. Fanconi anemia (cross)linked to DNA repair. Cell 123 (2005) 1191-1198
23. Mirchandani K.D., and D'Andrea A.D. The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair. Exp. Cell Res. 312 (2006) 2647-2653
24. Levitus M., Joenje H., and de Winter J.P. The Fanconi anemia pathway of genomic maintenance. Cell. Oncol. 28 (2006) 3-29
25. Huppert J.L., and Balasubramanian S. Prevalence of quadruplexes in the human genome. Nucleic Acids Res. 33 (2005) 2908-2916
26. Brenner S. The genetics of Caenorhabditis elegans. Genetics 77 (1974) 71-94