Activation of mGluR5 Attenuates Microglial Activation and Neuronal Apoptosis in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats

Neurochemical Research

Volumn 40, Issue 6, 2015, Pages 1121-1132

  Zhang, Zong yong ^a   Sun, Bao liang ^a   Liu, Jun ke ^b   Yang, Ming feng ^a   Li, Da wei ^a   Fang, Jie ^a   Zhang, Shuai ^a   Yuan, Qi lin ^b   Huang, Si luo ^b  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Early brain injury; mGluR5; Microglia activation; Neuronal apoptosis; Subarachnoid hemorrhage

Indexed keywords

2 CHLORO 5 HYDROXYPHENYLGLYCINE; CASPASE 3; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MESSENGER RNA; METABOTROPIC RECEPTOR 5; NEURON SPECIFIC NUCLEAR PROTEIN; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VU 0360172; 2-CHLORO-5-HYDROXYPHENYLGLYCINE; AMINO ACID RECEPTOR STIMULATING AGENT; CYCLIN D1; CYTOKINE; GLYCINE; GRM5 PROTEIN, RAT; PHENYLACETIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD CLOT; BRAIN CIRCULUS ARTERIOSUS; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; BRAIN STEM; BRAIN WATER; CELL ACTIVATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; EARLY BRAIN INJURY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOLOGY; LEFT HEMISPHERE; MALE; MICROGLIA; MORTALITY; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RIGHT HEMISPHERE; SINGLE DRUG DOSE; SUBARACHNOID HEMORRHAGE; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; PSYCHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BEHAVIOR, ANIMAL; BRAIN EDEMA; CASPASE 3; CEREBRAL CORTEX; CYCLIN D1; CYTOKINES; EXCITATORY AMINO ACID AGONISTS; GLYCINE; MACROPHAGE ACTIVATION; MALE; MICROGLIA; NEURONS; PHENYLACETATES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5; SUBARACHNOID HEMORRHAGE;

EID: 84930865144     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1572-7     Document Type: Article

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