Human Nav1.8: Enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons

Journal of Neurophysiology

Volumn 113, Issue 9, 2015, Pages 3172-3185

  Han, Chongyang ^a,b   Estacion, Mark ^a,b   Huang, Jianying ^a,b   Vasylyev, Dymtro ^a,b   Zhao, Peng ^a,b   Dib Hajj, Sulayman D ^a,b   Waxman, Stephen G ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Dorsal root ganglion; Nav1.8; Persistent current; Ramp current; Sodium channel

Indexed keywords

SODIUM CHANNEL NAV1.8; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; SCN10A PROTEIN, HUMAN;

ACTION POTENTIAL; ADULT; AGED; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CURRENT CLAMP TECHNIQUE; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KINETICS; MALE; MIDDLE AGED; MOUSE; NERVE CELL; NONHUMAN; PERSISTENT CURRENT; PRIORITY JOURNAL; RAMP CURRENT; RAT; SODIUM CURRENT; SPINAL GANGLION; VOLTAGE CLAMP TECHNIQUE; ANIMAL; BIOPHYSICS; CHANNEL GATING; CYTOLOGY; DRUG EFFECTS; ELECTROSTIMULATION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; TRANSGENIC MOUSE;

AGED; ANIMALS; BIOPHYSICS; ELECTRIC STIMULATION; FEMALE; GANGLIA, SPINAL; GREEN FLUORESCENT PROTEINS; HUMANS; ION CHANNEL GATING; MALE; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MIDDLE AGED; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; TRANSFECTION;

EID: 84930860348     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00113.2015     Document Type: Article

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