Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 308, Issue 11, 2015, Pages E933-E941

  Nguyen, Tuyet Thi ^a   Quan, Xianglan ^a   Hwang, Kyu Hee ^a   Xu, Shanhua ^a   Das, Ranjan ^a   Choi, Seong Kyung ^a   Wiederkehr, Andreas ^b   Wollheim, Claes B ^c   Cha, Seung Kuy ^a   Park, Kyu Sang ^a  

^a Yonsei University Wonju College of Medicine   (South Korea)

^b NESTLÉ RESEARCH CENTER   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

ER stress; Hyperphosphatemia; Insulin secretion; Mitochondrial permeability transition pore; Superoxide

Indexed keywords

CALCIUM ION; CASPASE; INSULIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHATE; SUPEROXIDE; CARRIER PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CALCIUM SIGNALING; CELL DEATH; CYTOTOXICITY; DEPOLARIZATION; ENZYME ACTIVATION; HYPERPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL CULTURE; DRUG EFFECTS; MALE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELLS, CULTURED; INSULIN; INSULIN-SECRETING CELLS; MALE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 84930855097     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00009.2015     Document Type: Article

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