Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells

Journal of Biological Chemistry

Volumn 290, Issue 7, 2015, Pages 4086-4096

  Quan, Xianglan ^a   Nguyen, Tuyet Thi ^a   Choi, Seong Kyung ^a   Xu, Shanhua ^a   Das, Ranjan ^a   Cha, Seung Kuy ^a   Kim, Nari ^b   Han, Jin ^b   Wiederkehr, Andreas ^c   Wollheim, Claes B ^d   Park, Kyu Sang ^a  

^a Yonsei University Wonju   (South Korea)

^b Inje University   (South Korea)

^c Nestlé Institute of Health Sciences   (South Korea)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INSULIN; METABOLISM; PH;

ENERGY METABOLISM; INSULIN SECRETION; OXIDATIVE PHOSPHORYLATION; PH GRADIENTS; RESPIRATORY CHAINS;

PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANTIPORTER; CALCIUM ION; CELL MEMBRANE PROTEIN; PROTEIN LETM1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CALCIUM; CALCIUM BINDING PROTEIN; CALCIUM CHANNEL; CATION TRANSPORT PROTEIN; GLUCOSE; INSULIN; LETM1 PROTEIN, RAT; MESSENGER RNA; MITOCHONDRIAL CALCIUM UNIPORTER;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE PERMEABILITY; CELL PH; ENZYME SYNTHESIS; HYPERPOLARIZATION; INSULIN METABOLISM; INSULIN RELEASE; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; RAT; REGULATORY MECHANISM; RESPIRATORY CHAIN; RNA TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; ENERGY METABOLISM; ENZYME IMMUNOASSAY; GENETICS; INSULINOMA; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PATHOLOGY; PH; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS; CALCIUM-BINDING PROTEINS; CATION TRANSPORT PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; ENERGY METABOLISM; GLUCOSE; HYDROGEN-ION CONCENTRATION; IMMUNOENZYME TECHNIQUES; INSULIN; INSULIN-SECRETING CELLS; INSULINOMA; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84922949995     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.632547     Document Type: Article

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