Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

PLoS Genetics

Volumn 11, Issue 5, 2015, Pages

  Dialynas, George ^a,d   Shrestha, Om K ^a,e   Ponce, Jessica M ^b   Zwerger, Monika ^c,f   Thiemann, Dylan A ^a   Young, Grant H ^a   Moore, Steven A ^a   Yu, Liping ^a   Lammerding, Jan ^c   Wallrath, Lori L ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c School of Integrative Plant Sciences   (United States)

^d STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ENVELOPE PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN P62; PROTEIN SQSTM1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; KEAP1 PROTEIN, HUMAN; LAMIN A; LAMIN C; LMNA PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SEQUESTOSOME 1; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; BIOACCUMULATION; BIOCHEMICAL ANALYSIS; CELL STRESS; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; ENZYME REGULATION; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; GENE TRANSLOCATION; HUMAN; HUMAN TISSUE; LMNA GENE; MISSENSE MUTATION; MUSCLE BIOPSY; MUSCULAR DYSTROPHY; NONHUMAN; NUCLEAR LAMINA; OXIDATIVE STRESS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN METABOLISM; REDUCTIVE STRESS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL NUCLEUS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; MUTATION; PROTEIN CONFORMATION; SKELETAL MUSCLE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL NUCLEUS; DROSOPHILA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HOMEOSTASIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LAMIN TYPE A; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; MUTATION; NF-E2-RELATED FACTOR 2; NUCLEAR LAMINA; OXIDATIVE STRESS; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUESTOSOME-1 PROTEIN; SIGNAL TRANSDUCTION;

EID: 84930811144     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005231     Document Type: Article

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