Histone Deacetylase Inhibitor, Trichostatin A, Improves Learning and Memory in High-Fat Diet-Induced Cognitive Deficits in Mice

Journal of Molecular Neuroscience

Volumn 56, Issue 1, 2015, Pages 1-11

  Sharma, Sorabh ^a   Taliyan, Rajeev ^a   Ramagiri, Shruti ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Alzheimer s disease; Cognitive deficit; Diabetes mellitus; Histone deacetylases; Oxidative stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; TRICHOSTATIN A; CHOLESTEROL; GLUCOSE BLOOD LEVEL; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL STRESS; BRAIN HOMOGENATE; CHOLESTEROL BLOOD LEVEL; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INVESTIGATIVE PROCEDURES; LEARNING; LIPID DIET; MALE; MEMORY; METABOLIC DISORDER; METABOLIC SYNDROME X; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; OXIDATIVE STRESS; PASSIVE AVOIDANCE; TASK PERFORMANCE; TRIACYLGLYCEROL BLOOD LEVEL; ADVERSE EFFECTS; ANIMAL; BLOOD; BRAIN; COGNITION DISORDERS; DRUG EFFECTS; MAZE TEST; METABOLISM; PHYSIOLOGY;

MUS;

ANIMALS; BLOOD GLUCOSE; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL; COGNITION DISORDERS; DIET, HIGH-FAT; HISTONE DEACETYLASE INHIBITORS; HYDROXAMIC ACIDS; MALE; MAZE LEARNING; MEMORY; METABOLIC SYNDROME X; MICE; OXIDATIVE STRESS; TRIGLYCERIDES;

EID: 84930764605     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-014-0461-x     Document Type: Article

References (45)

1. Akagiri S, Naito Y, Ichikawa H et al (2008) A mouse model of metabolic syndrome; increase in visceral adipose tissue precedes the development of fatty liver and insulin resistance in high-fat diet-fed male KK/Ta mice. J Clin Biochem Nutr 42:150–157
2. Anstey KJ, Cherbuin N, Budge M et al (2011) Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes Rev 12:e426–e437
3. Beydoun MA, Beydoun HA, Wang Y (2008) Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and metaanalysis. Obes Rev 9:204–218
4. Bruce-Keller AJ, Keller JN, Morrison CD (2009) Obesity and vulnerability of the CNS. Biochim Biophys Acta 1792:395–400
5. Buettner R, Parhofer KG, Woenckhaus M et al (2006) Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 36:485–501
6. Calfa G, Chapleau CA, Campbell S et al (2012) HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons. Hippocampus 22:1493–1500
7. Choi Y, Park SK, Kim HM et al (2008) Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp Mol Med 40:574–581
8. Datusalia AK, Sharma SS (2014) Amelioration of diabetes-induced cognitive deficits by GSK-3β inhibition is attributed to modulation of neurotransmitters and neuroinflammation. Mol Neurobiol 50:390–405
9. De Souza CT, Araujo EP, Bordin S et al (2005) Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 146:4192–4199
10. Deshmukh R, Sharma V, Mehan S et al (2009) Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine - a PDE1 inhibitor. Eur J Pharmacol 620:49–56
11. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77
12. Ellman GL, Courtney KD, Andres V (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95
13. Fleiss B, Nilsson MK, Blomgren K (2012) Neuroprotection by the histone deacetylase inhibitor trichostatin a in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injury. J Neuroinflammation 9:1–15
14. Funato H, Oda S, Yokofujita J et al (2011) Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus. PLoS ONE 6:e18950
15. Galmozzi A, Mitro N, Ferrari A (2013) Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes 62:732–742
16. Gao Z, Yin J, Zhang J et al (2009) Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58:1509–1517
17. Green LC, Wagner DA, Glgowski J et al (1982) Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Ann Biochem Exp Med 126:131–135
18. Harrison IF, Dexter DT (2013) Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson’s disease? Pharmacol Ther 140:34–52
19. Jianping Y (2013) Improving insulin sensitivity with HDAC inhibitor. Diabetes 62:685–687
20. Koppel I, Timmusk T (2013) Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors. Neuropharmacology 75:106–115
21. Kumar A, Sharma S, Prashar A et al (2014) Effect of licofelone—a dual COX/5-LOX inhibitor in intracerebroventricular streptozotocin-induced behavioral and biochemical abnormalities in rats. J Mol Neurosci. doi:10.1007/s12031-014-0414-4
22. Leoni F, Zaliani A, Bertolini G et al (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc Natl Acad Sci U S A 99:2995–3000
23. Lowry OH, Rosebrough NJ, Farr AL et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
24. Mesulam MM, Asuncion MM (1987) Cholinesterases within neurofibrillary tangles related to age and Alzheimer’s disease. Ann Neurol 22:223–228
25. Miller AA, Spencer SJ (2014) Obesity and neuroinflammation: a pathway to cognitive impairment. Brain Behav Immun
26. Miranda MI, Ferreira G, Ramirez-Lugo L et al (2003) Role of cholinergic system on the construction of memories: taste memory encoding. Neurobiol Learn Mem 80:211–222
27. Morris RGM (1984) Development of a water-maze procedure for studying spatial learning in the rats. J Neurosci Meth 11:47–60
28. Padurariu M, Ciobica A, Hritcu L et al (2010) Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer’s disease. Neurosci Lett 469:6–10
29. Pang PT, Teng HK, Zaitsev E et al (2004) Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science 306:487–491
30. Pathan AR, Gaikwad B, Viswanad B et al (2008) Rosiglitazone attenuates the cognitive deficits induced by high fat diet feeding in rats. Eur J Pharmacol 589:176–179
31. Pocernich CB, Butterfield DA (2012) Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta 1822:625–630
32. Qiu WQ, Folstein MF (2006) Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer’s disease: review and hypothesis. Neurobiol Aging 27:190–198
33. Roriz-Filho SJ, Sa-Roriz TM, Rosset I et al (2009) Prediabetes, brain aging, and cognition. Biochim Biophys Acta 1792:432–443
34. Sailajaa BS, Cohen-Carmona D, Zimmermanb G (2012) Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4. PNAS 109:E3687–E3695
35. Sharma S, Taliyan R (2014) Neuroprotective role of Indirubin-3’-monoxime, a GSKβ inhibitor in high fat diet induced cognitive impairment in mice. Biochem Biophys Res Commun 452:1009-1015
36. Shimazu T, Hirschey MD, Newman J et al (2013) Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339:211–214
37. Srinivasan K, Viswanad B, Asrat L et al (2005) Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313–320
38. Suzuki R, Lee K, Jing E et al (2010) Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 12:567–579
39. Takeda S, Sato N, Rakugi H et al (2011) Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function. Mol Biosyst 7:1822–1827
40. Thaler JP, Yi CX, Schur EA et al (2012) Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 122:153–162
41. Wang X, Wei X, Pang Q et al (2012) Histone deacetylases and their inhibitors: molecular mechanisms and therapeutic implications in diabetes mellitus. Acta Pharmaceutica Sinica B 2:387–395
42. Wessels AM, Lane KA, Gao S et al (2011) Diabetes and cognitive decline in elderly African Americans: a 15-year follow-up study. Alzheimers Dement 7:418–424
43. Wills ED (1996) Mechanism of lipid peroxide formation in animal. Biochem J 99:667–676
44. Xu K, Dai XL, Huang HC et al (2011) Targeting HDAC: a promising therapy for Alzheimer’s disease. Oxid Med Cell Longev 2011:1–5
45. Zhang L, Bruce-Keller AJ, Dasuri K et al (2009) Diet-induced metabolic disturbances as modulators of brain homeostasis. Biochim Biophys Acta 1792:417–422