NAD+-dependent SIRT1 deactivation has a key role on ischemia-reperfusion-induced apoptosis

Vascular Pharmacology

Volumn 70, Issue , 2015, Pages 35-44

  Cattelan, Arianna ^a   Ceolotto, Giulio ^a   Bova, Sergio ^a   Albiero, Mattia ^b   Kuppusamy, Maniselvan ^a   De Martin, Sara ^a   Semplicini, Andrea ^a   Fadini, Gian Paolo ^a,b   de Kreutzenberg, Saula Vigili ^a   Avogaro, Angelo ^a,b  

^a UNIVERSITY OF PADOVA   (Italy)

^b VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

Apoptosis; Caspase 3; NAD+; Reperfusion injury; SIRTs

Indexed keywords

CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DAPORINAD; GLUCOSE; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; MANNITOL; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN P53; RESVERATROL; SIRTUIN 1; SIRTUIN 6; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR NRF1; CASP3 PROTEIN, RAT; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; HEAT SHOCK TRANSCRIPTION FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NERVE PROTEIN; SIRT1 PROTEIN, RAT; SIRTUIN; SIRTUIN 6, RAT; STILBENE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DEACETYLATION; DOWN REGULATION; DRUG MECHANISM; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; UPREGULATION; ANIMAL; BINDING SITE; CARDIAC MUSCLE CELL; DEFICIENCY; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; ISOLATED HEART; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; SIGNAL TRANSDUCTION; TIME FACTOR; WISTAR KYOTO RAT;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BINDING SITES; CASPASE 3; DNA-BINDING PROTEINS; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; GLUCOSE; ISOLATED HEART PREPARATION; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NAD; NERVE TISSUE PROTEINS; PROMOTER REGIONS, GENETIC; RATS, INBRED WKY; SIGNAL TRANSDUCTION; SIRTUIN 1; SIRTUINS; STILBENES; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84930755060     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2015.02.004     Document Type: Article

References (35)

1. Libby P., Theroux P. Pathophysiology of coronary artery disease. Circulation 2005, 111:3481-3488.
2. Gottlieb R.A. Cell death pathways in acute ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther 2011, 16:233-238.
3. Dumont E.A., Hofstra L., van Heerde W.L., van den Eijnde S., Doevendans P.A., DeMuinck E., et al. Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model. Circulation 2000, 102:1564-1568.
4. Haigis M.C., Sinclair D.A. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010, 5:253-295.
5. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
6. de Kreutzenberg S.V., Ceolotto G., Papparella I., Bortoluzzi A., Semplicini A., Dalla Man C., et al. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes 2010, 59:1006-1015.
7. Chen D., Bruno J., Easlon E., Lin S.J., Cheng H.L., Alt F.W., et al. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 2008, 22:1753-1757.
8. + synthesis, protects the heart from ischemia and reperfusion. PLoS ONE 2014, 9:e98972.
9. Rane S., He M., Sayed D., Vashistha H., Malhotra A., Sadoshima J., et al. Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res 2009, 104:879-886.
10. Alcendor R.R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007, 100:1512-1521.
11. Alcendor R.R., Kirshenbaum L.A., Imai S., Vatner S.F., Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circ Res 2004, 95:971-980.
12. Shinmura K., Tamaki K., Sano M., Nakashima-Kamimura N., Wolf A.M., et al. Caloric restriction primes mitochondria for ischemic stress by deacetylating specific mitochondrial proteins of the electron transport chain. Circ Res 2011, 109:396-406.
13. Nadtochiy S.M., Redman E., Rahman I., Brookes P.S. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovasc Res 2011, 89:643-649.
14. Nadtochiy S.M., Yao H., McBurney M.W., Gu W., Guarente L., Rahman I., et al. SIRT1 mediated acute cardioprotection. Am J Physiol Heart Circ Physiol 2011, 301:H1506-H1512.
15. Ray P.S., Maulik G., Cordis G.A., Bertelli A.E., Bertelli A., Das D.K. The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Radic Biol Med 1999, 27:160-169.
16. Hsu C.P., Odewale I., Alcendor R.R., Sadoshima J. Sirt1 protects the heart from aging and stress. Biol Chem 2008, 389:221-231.
17. Hsu C.P., Zhai P., Yamamoto T., Maejima Y., Matsushima S., Hariharan N., et al. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 2010, 122:2170-2182.
18. Bova S., Cargnelli G., D'Amato E., Forti S., Yang Q., Trevisi L., et al. Calcium-antagonist effects of norbormide on isolated perfused heart and cardiac myocytes of guinea pig: a comparison with verapamil. Br J Pharmacol 1997, 120:19-24.
19. Papparella I., Ceolotto G., Berto L., Cavalli M., Bova S., Cargnelli G., et al. Vitamin C prevents zidovudine-induced NAD(P)H oxidase activation and hypertension in the rat. Cardiovasc Res 2007, 73:432-438.
20. Ceolotto G., De Kreutzenberg S.V., Cattelan A., Fabricio A.S., Squarcina E., Gion M., et al. Sirtuin 1 stabilization by HuR represses TNF-α- and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro: relevance to human metabolic syndrome. Clin Sci (Lond) 2014, 127:449-461.
21. Revollo J.R., Li X. The ways and means that fine tune Sirt1 activity. Trends Biochem Sci 2013, 38:160-167.
22. Xiong S., Salazar G., Patrushev N., Alexander W. FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem 2011, 286:5289-5299.
23. Park S.J., Ahmad F., Philp A., Baar K., Williams T., Luo H., et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012, 148:421-433.
24. Schulz R., Streller F., Scheel A.H., Rüschoff J., Reinert M.-C, Dobbelstein M., et al. HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer. Cell Death Dis 2014, 5:e980.
25. Jäättelä M., Wissing D., Kokholm K., Kallunki T., Egeblad M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J 1998, 17:6124-6134.
26. Zou Y., Zhu W., Sakamoto M., Qin Y., Akazawa H., Toko H., et al. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003, 108:3024-3030.
27. Kim H.S., Xiao C., Wang R.H., Lahusen T., Xu X., Vassilopoulos A., et al. Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 2010, 12:224-236.
28. Yamamoto T., Sadoshima J. Protection of the heart agains ischemia/reperfusion by silent information regulator 1. Trends Cardiovasc Med 2011, 21:27-32.
29. Sengupta A., Molkentin J.D., Yutzey K.E. FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 2009, 284:28319-28331.
30. Puthanveetil P., Wan A., Rodrigues B. FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival. Cardiovasc Res 2013, 97:393-403.
31. + synthesis in cardiac myocytes. Circ Res 2009, 105:481-491.
32. Anckar J., Sistonen L. Regulation of HSF1 function in the heat stress response: implications in aging and disease. Annu Rev Biochem 2011, 80:1089-1115.
33. Westerheide S.D., Anckar J., Stevens S.M., Sistonen L., Morimoto R.I. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science 2009, 323:1063-1066.
34. Sundaresan N.R., Vasudevan P., Zhong L., Kim G., Samant S., Parekh V., et al. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med 2012, 18:1643-1650.
35. Cai Y., Yu S.S., Chen S.R., Pi R.B., Gao S., Li H., et al. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett 2012, 586:866-874.