-
1
-
-
0025120211
-
Regulation of the mevalonate pathway
-
J.L. Goldstein, M.S. Brown Regulation of the mevalonate pathway Nature 343 1990 425 430
-
(1990)
Nature
, vol.343
, pp. 425-430
-
-
Goldstein, J.L.1
Brown, M.S.2
-
2
-
-
0028883828
-
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
-
West of Scotland Coronary Prevention Study Group I.
-
J. Shepherd, S.M. Cobbe, I. Ford West of Scotland Coronary Prevention Study Group Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia N Engl J Med 333 1995 1301 1307
-
(1995)
N Engl J Med
, vol.333
, pp. 1301-1307
-
-
Shepherd, J.1
Cobbe, S.M.2
Ford3
-
3
-
-
0027987849
-
Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
-
Scandinavian Simvastatin Survival Study Group
-
Scandinavian Simvastatin Survival Study Group Randomised trial of cholesterol lowering in 4,444 patients with coronary heart disease the Scandinavian Simvastatin Survival Study (4S) Lancet 344 1994 1383 1389
-
(1994)
Lancet
, vol.344
, pp. 1383-1389
-
-
-
4
-
-
0342981862
-
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
-
Cholesterol and Recurrent Events Trial Investigators L.A.
-
F.M. Sacks, M.A. Pfeffer, L.A. Moye Cholesterol and Recurrent Events Trial Investigators The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels N Engl J Med 335 1996 1001 1009
-
(1996)
N Engl J Med
, vol.335
, pp. 1001-1009
-
-
Sacks, F.M.1
Pfeffer, M.A.2
Moye3
-
5
-
-
0033536298
-
Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators
-
B. Pitt, D. Waters, W.V. Brown Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus Revascularization Treatment Investigators N Engl J Med 341 1999 70 76
-
(1999)
N Engl J Med
, vol.341
, pp. 70-76
-
-
Pitt, B.1
Waters, D.2
Brown, W.V.3
-
6
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
Y. Kureishi, Z. Luo, I. Shiojima The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 2000 1004 1010
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
-
7
-
-
0034683064
-
Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
-
H. Tong, W. Chen, C. Steenbergen Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C Circ Res 87 2000 309 315
-
(2000)
Circ Res
, vol.87
, pp. 309-315
-
-
Tong, H.1
Chen, W.2
Steenbergen, C.3
-
8
-
-
12344311866
-
Ischemic preconditioning protects by activating pro-survival kinases at reperfusion
-
D.J. Hausenloy, M.M. Mocanu, D.M. Yellon Ischemic preconditioning protects by activating pro-survival kinases at reperfusion Am J Physiol Heart Circ Physiol 288 2005 H971 H976
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Hausenloy, D.J.1
Mocanu, M.M.2
Yellon, D.M.3
-
9
-
-
0035572838
-
Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion
-
S.P. Jones, S.D. Trocha, D.J. Lefer Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion Arterioscler Thromb Vasc Biol 21 2001 2059 2064
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 2059-2064
-
-
Jones, S.P.1
Trocha, S.D.2
Lefer, D.J.3
-
10
-
-
0037419766
-
Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway
-
R.M. Bell, D.M. Yellon Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway J Am Coll Cardiol 41 2003 508 515
-
(2003)
J Am Coll Cardiol
, vol.41
, pp. 508-515
-
-
Bell, R.M.1
Yellon, D.M.2
-
11
-
-
0034942037
-
Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: An ex vivo study in isolated working rat hearts
-
P. Di Napoli, T.A. Antonio, A. Grilli Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression an ex vivo study in isolated working rat hearts Cardiovasc Res 51 2001 283 293
-
(2001)
Cardiovasc Res
, vol.51
, pp. 283-293
-
-
Di Napoli, P.1
Antonio, T.A.2
Grilli, A.3
-
12
-
-
0033551539
-
Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts
-
A.M. Lefer, B. Campbell, Y.K. Shin Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts Circulation 100 1999 178 184
-
(1999)
Circulation
, vol.100
, pp. 178-184
-
-
Lefer, A.M.1
Campbell, B.2
Shin, Y.K.3
-
13
-
-
0032748324
-
Are all HMG-CoA reductase inhibitors protective against ischemic heart disease?
-
K. Ichihara, K. Satoh, A. Yamamoto [Are all HMG-CoA reductase inhibitors protective against ischemic heart disease?] Nippon Yakurigaku Zasshi 114 Suppl 1 1999 142P 149P
-
(1999)
Nippon Yakurigaku Zasshi
, vol.114
, Issue.1 SUPPL.
-
-
Ichihara, K.1
Satoh, K.2
Yamamoto, A.3
-
14
-
-
0027369405
-
Influences of pravastatin and simvastatin, HMG-CoA reductase inhibitors, on myocardial stunning in dogs
-
K. Ichihara, K. Satoh, Y. Abiko Influences of pravastatin and simvastatin, HMG-CoA reductase inhibitors, on myocardial stunning in dogs J Cardiovasc Pharmacol 22 1993 852 856
-
(1993)
J Cardiovasc Pharmacol
, vol.22
, pp. 852-856
-
-
Ichihara, K.1
Satoh, K.2
Abiko, Y.3
-
15
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
S.R. Datta, H. Dudek, X. Tao Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery Cell 91 1997 231 241
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
-
16
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
A. Brunet, A. Bonni, M.J. Zigmond Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Cell 96 1999 857 868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
-
18
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
T. Matsui, L. Li, J.C. Wu Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart J Biol Chem 277 2002 22896 22901
-
(2002)
J Biol Chem
, vol.277
, pp. 22896-22901
-
-
Matsui, T.1
Li, L.2
Wu, J.C.3
-
19
-
-
3042718647
-
Regulation of cell size and contractile function by AKT in cardiomyocytes
-
M.V. Latronico, S. Costinean, M.L. Lavitrano Regulation of cell size and contractile function by AKT in cardiomyocytes Ann N Y Acad Sci 1015 2004 250 260
-
(2004)
Ann N Y Acad Sci
, vol.1015
, pp. 250-260
-
-
Latronico, M.V.1
Costinean, S.2
Lavitrano, M.L.3
-
20
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
M.A. Crackower, G.Y. Oudit, I. Kozieradzki Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways Cell 110 2002 737 749
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
Oudit, G.Y.2
Kozieradzki, I.3
-
21
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
H.G. Wendel, E. De Stanchina, J.S. Fridman Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy Nature 428 2004 332 337
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.G.1
De Stanchina, E.2
Fridman, J.S.3
-
22
-
-
0034742120
-
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
M. Sun, G. Wang, J.E. Paciga AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells Am J Pathol 159 2001 431 437
-
(2001)
Am J Pathol
, vol.159
, pp. 431-437
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
-
23
-
-
2542451142
-
Deficiency of PTEN accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice
-
Y. Li, K. Podsypanina, X. Liu Deficiency of PTEN accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice BMC Mol Biol 2 2001 2
-
(2001)
BMC Mol Biol
, vol.2
, pp. 2
-
-
Li, Y.1
Podsypanina, K.2
Liu, X.3
-
24
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
-
G.Y. Oudit, H. Sun, B.G. Kerfant, M.A. Crackower, J.M. Penninger, P.H. Backx The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease J Mol Cell Cardiol 37 2004 449 471
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.Y.1
Sun, H.2
Kerfant, B.G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
25
-
-
0035804846
-
Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial
-
G.G. Schwartz, A.G. Olsson, M.D. Ezekowitz Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial JAMA 285 2001 1711 1718
-
(2001)
JAMA
, vol.285
, pp. 1711-1718
-
-
Schwartz, G.G.1
Olsson, A.G.2
Ezekowitz, M.D.3
-
26
-
-
0032572086
-
Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study
-
J.R. Downs, M. Clearfield, S. Weis Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study JAMA 279 1998 1615 1622
-
(1998)
JAMA
, vol.279
, pp. 1615-1622
-
-
Downs, J.R.1
Clearfield, M.2
Weis, S.3
-
27
-
-
0034027357
-
Inhibitors of HMG CoA reductase: New modes of action, new indications?
-
M. Essig, F. Vrtovsnik, G. Friedlander [Inhibitors of HMG CoA reductase new modes of action, new indications?] Therapie 55 2000 43 49
-
(2000)
Therapie
, vol.55
, pp. 43-49
-
-
Essig, M.1
Vrtovsnik, F.2
Friedlander, G.3
-
28
-
-
0037189048
-
Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice
-
U. Laufs, K. Gertz, U. Dirnagl Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice Brain Res 942 2002 23 30
-
(2002)
Brain Res
, vol.942
, pp. 23-30
-
-
Laufs, U.1
Gertz, K.2
Dirnagl, U.3
-
29
-
-
0034471646
-
Direct vascular effects of HMG-CoA reductase inhibitors
-
U. Laufs, J.K. Liao Direct vascular effects of HMG-CoA reductase inhibitors Trends Cardiovasc Med 10 2000 143 148
-
(2000)
Trends Cardiovasc Med
, vol.10
, pp. 143-148
-
-
Laufs, U.1
Liao, J.K.2
-
30
-
-
0036280932
-
Clinical review 145: Pleiotropic effects of statins: Lipid reduction and beyond
-
S.I. McFarlane, R. Muniyappa, R. Francisco Clinical review 145: pleiotropic effects of statins: lipid reduction and beyond J Clin Endocrinol Metab 87 2002 1451 1458
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1451-1458
-
-
McFarlane, S.I.1
Muniyappa, R.2
Francisco, R.3
-
31
-
-
0038171189
-
Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat
-
N.S. Wayman, B.L. Ellis, C. Thiemermann Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat Med Sci Monit 9 2003 BR155 BR159
-
(2003)
Med Sci Monit
, vol.9
-
-
Wayman, N.S.1
Ellis, B.L.2
Thiemermann, C.3
-
32
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
Y. Kureishi, Z. Luo, I. Shiojima The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 2000 1004 1010
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
-
33
-
-
0034908652
-
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
-
S. Dimmeler, A. Aicher, M. Vasa HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway J Clin Invest 108 2001 391 397
-
(2001)
J Clin Invest
, vol.108
, pp. 391-397
-
-
Dimmeler, S.1
Aicher, A.2
Vasa, M.3
-
34
-
-
0036623989
-
PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning
-
M.M. Mocanu, R.M. Bell, D.M. Yellon PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning J Mol Cell Cardiol 34 2002 661 668
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 661-668
-
-
Mocanu, M.M.1
Bell, R.M.2
Yellon, D.M.3
-
35
-
-
1142309743
-
New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway
-
D.J. Hausenloy, D.M. Yellon New directions for protecting the heart against ischaemia-reperfusion injury targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway (review) Cardiovasc Res 61 2004 448 460
-
(2004)
Cardiovasc Res
, vol.61
, pp. 448-460
-
-
Hausenloy, D.J.1
Yellon, D.M.2
-
36
-
-
3142566467
-
Cross-talk between the survival kinases during early reperfusion: Its contribution to ischemic preconditioning
-
D.J. Hausenloy, M.M. Mocanu, D.M. Yellon Cross-talk between the survival kinases during early reperfusion its contribution to ischemic preconditioning Cardiovasc Res 63 2004 305 312
-
(2004)
Cardiovasc Res
, vol.63
, pp. 305-312
-
-
Hausenloy, D.J.1
Mocanu, M.M.2
Yellon, D.M.3
-
37
-
-
0036217991
-
Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme a reductase decreases energy supply to the myocardium in rats
-
O.I. Pisarenko, I.M. Studneva, V.Z. Lankin Inhibitor of beta-hydroxy-beta-methylglutaryl coenzyme A reductase decreases energy supply to the myocardium in rats Bull Exp Biol Med 1 2001 956 958
-
(2001)
Bull Exp Biol Med
, vol.1
, pp. 956-958
-
-
Pisarenko, O.I.1
Studneva, I.M.2
Lankin, V.Z.3
-
38
-
-
0033958781
-
Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs
-
K. Satoh, K. Ichihara Lipophilic HMG-CoA reductase inhibitors increase myocardial stunning in dogs J Cardiovasc Pharmacol 35 2000 256 262
-
(2000)
J Cardiovasc Pharmacol
, vol.35
, pp. 256-262
-
-
Satoh, K.1
Ichihara, K.2
-
39
-
-
0142011466
-
PTEN: From pathology to biology
-
M.L. Sulis, R. Parsons PTEN from pathology to biology Trends Cell Biol 13 2003 478 483
-
(2003)
Trends Cell Biol
, vol.13
, pp. 478-483
-
-
Sulis, M.L.1
Parsons, R.2
-
40
-
-
0345097326
-
SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide
-
L.M. Sly, M.J. Rauh, J. Kalesnikoff, T. Buchse, G. Krystal SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide Exp Hematol 31 2003 1170 1181
-
(2003)
Exp Hematol
, vol.31
, pp. 1170-1181
-
-
Sly, L.M.1
Rauh, M.J.2
Kalesnikoff, J.3
Buchse, T.4
Krystal, G.5
-
41
-
-
0032167375
-
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia
-
C. Weinbrenner, C.P. Baines, G.-S. Liu Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia Circulation 98 1998 899 905
-
(1998)
Circulation
, vol.98
, pp. 899-905
-
-
Weinbrenner, C.1
Baines, C.P.2
Liu, G.-S.3
-
42
-
-
0032407977
-
Reduction of infarct size in isolated rat heart by CsA and FK506: Possible role of phosphatase inhibition
-
Q. Cai, G.F. Baxter, D.M. Yellon Reduction of infarct size in isolated rat heart by CsA and FK506 possible role of phosphatase inhibition Cardiovasc Drugs Ther 12 1998 499 501
-
(1998)
Cardiovasc Drugs Ther
, vol.12
, pp. 499-501
-
-
Cai, Q.1
Baxter, G.F.2
Yellon, D.M.3
|