Cilostazol, a phosphodiesterase inhibitor, improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty Rat, a model of spontaneous NIDDM

Diabetes, Obesity and Metabolism

Volumn 1, Issue 1, 1999, Pages 37-41

  Nakaya, Y ^a   Minami, A ^a   Sakamoto, S ^a   Niwa, Y ^a   Ohnaka, M ^a   Harada, N ^a   Nakamura, T ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cilostazol; Insulin sensitivity; Non insulin dependent diabetes mellitus; Otsuka Long Evans Tokushima Fatty rat

Indexed keywords

CILOSTAZOL; PHOSPHODIESTERASE INHIBITOR; TETRAZOLE DERIVATIVE;

ABDOMEN; ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; DIET; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; REFERENCE VALUE;

ABDOMEN; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; DIET; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, INBRED OLETF; REFERENCE VALUES; TETRAZOLES;

EID: 0032601090     PISSN: 14628902     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1463-1326.1999.00002.x     Document Type: Article

References (22)

1. Kaplan NM. The deadly quartet. Arch Intern Medicine 1989; 149: 1514-1520.
2. Berne C, Pollare T, Lithell H. Effects of antihypertensive treatment on insulin sensitivity with special reference to ACE inhibitors. Diabetes Care 1991; 14 (Suppl.): 39-47.
3. Kodama J, Katayama S, Tanaka K, Itabashi A, Kawazu S, Ishii J. Effect of captopril on glucose metabolism: a possible role of augmented post prandial forearm blood flow. Diabetes Care 1990; 13: 1109-1111.
4. Giordano M, Matsuda M, Sanders L, et al. Effects of angiotensin-converting enzyme inhibitors, Ca channel antagonists and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension. Diabetes 1995; 44: 665-671.
5. Lithell HOL. Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism. Diabetes Care 1991; 14: 203-209.
6. Harano Y, Kageyama A, Hirose J, et al. Improvement of insulin sensitivity for glucose metabolism with the long-acting Ca-channel blocker amlodipine in essential hypertensive subjects. Metabolism 1995; 44: 315-319.
7. Thurig C, Bohlen L, Schneider M, et al. Lisinopril is neutral to insulin sensitivity and serum lipoproteins in essential hypertensive patients. Eur J Clin Pharmacol 1995; 49: 21-26.
8. Lithell HO. Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism. Diabetes Care 1991; 14: 203-209.
9. Momo K, Someya K, Tachiiri T, et al. Effects of the new antiplatelet agent 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl) pyrazolo [1,5-a] pyridine on platelet aggregation and thrombosis in experimental animals. Arzneimittelforschung 1992; 42: 32-39.
10. Okuda Y, Mizutani M, Ikegami T, et al. Hemodynamic effects of cilostazol on peripheral artery in patients with diabetic neuropathy. Arzneimittelforschung 1992; 42: 540-542.
11. Kawano K, Hirashima T, Mori S, Natori T. OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain. Diabetes Res Clin Prac 1994; 24: S317-S320.
12. Shima K, Shi K, Sano T, et al. Is exercise training effective in preventing diabetes mellitus in the Otsuka-Long-Evans-Tokushima fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus? Metabolism 1993; 42: 971-977.
13. Desbuquis B, Aurbach GD. Use of polyethylene glycol to separate free and antibody bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 1971; 33: 732-739.
14. Ma Z, Gingerich RL, Santiago JV, et al. Radioimmunoassay of leptin in human plasma. Clin Chem 1996; 42; 942-946.
15. Sato T, Asahi Y, Toide K, Nakayama N. Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rats, a new model of NIDDM. Diabetologia 1995; 38: 1033-1041.
16. Sakamoto S, Minami K, Niwa Y, et al. Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM. Diabetes 1998; 47: 82-86.
17. Ishida K, Mizuno A, Min Z, et al. Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion? Metabolism 1995; 44: 940-945.
18. Hotta N, Koh N, Sakakibaia F, et al. Nerve function and blood flow in Otsuka Long-Evans Tokushima Fatty rats with sucrose feeding: effect of an anticoagulant. Eur J Pharmacol 1996; 313: 201-209.
19. Suzuki S, Ohtomo M, Satoh Y, et al. Effect of manidipine and delapril on insulin sensitivity in type 2 diabetic patients with essential hypertension. Diabetes Res Clin Prac 1996; 33: 43-51.
20. Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997; 272: 10585-10593.
21. Parker JC, VanVolkenburg MA, Ketchum RJ, et al. Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion. Biochem Biophys Res Comm 1995; 217: 916-923.
22. Wesslau C, Eriksson JW, Smith U. Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness: evidence against a significant role of Gi in insulin signal transduction. Biochem Biophys Res Comm 1993; 196: 287-293.