Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio

Bioscience Reports

Volumn 35, Issue , 2015, Pages

  Yi, Jingwen ^a   Yang, Xiaoguang ^a   Zheng, Lihua ^a   Yang, Guang ^b   Sun, Luguo ^a   Bao, Yongli ^a   Wu, Yin ^a   Huang, Yanxin ^a   Yu, Chunlei ^a   Yang, Shao Nian ^a,c   Li, Yuxin ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b CHANGCHUN UNIVERSITY OF CHINESE MEDICINE   (China)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Anti cancer; Cell destruction; Cell growth; Hypericum perforatum; Pancreatic endocrine tumour; Photopharmacology

Indexed keywords

CASPASE 3; CASPASE 9; HYPERICIN; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE; BAX PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PERYLENE; PHOTOSENSITIZING AGENT;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; INSULINOMA; INTERNALIZATION; NONHUMAN; PHOTOACTIVATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TUMOR CELL; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; METABOLISM; PANCREATIC NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; PROCEDURES; RAT; TUMOR CELL LINE;

HYPERICUM PERFORATUM;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INSULINOMA; MAP KINASE KINASE 4; PANCREATIC NEOPLASMS; PERYLENE; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS;

EID: 84930682117     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20150028     Document Type: Article

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