CaV2.3 channel and PKCλ: New players in insulin secretion

Journal of Clinical Investigation

Volumn 115, Issue 1, 2005, Pages 16-20

  Yang, Shao Nian ^a   Berggren, Per Olof ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CACNA1E PROTEIN, HUMAN; CALCIUM CHANNEL R TYPE; CATION TRANSPORT PROTEIN; INSULIN; ISOENZYME; ISOPROTEIN; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA;

CALCIUM CHANNEL CA V 2.3; CALCIUM TRANSPORT; CELL FUNCTION; GENE EXPRESSION; INSULIN RELEASE; KNOCKOUT MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; NOTE; PANCREAS ISLET; SECRETION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALCIUM CHANNELS, R-TYPE; CATION TRANSPORT PROTEINS; GENE EXPRESSION REGULATION; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISOENZYMES; PROTEIN ISOFORMS; PROTEIN KINASE C;

EID: 13744249301     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200523970     Document Type: Review

References (32)

1. V channel regulation in physiology and pathophysiology. Am. J. Physiol. Endocrinol. Metab. 288:E16-E28.
2. Aizawa, T., Komatsu, M., Asanuma, N., Sato, Y., and Sharp, G.W. 1998. Glucose action 'beyond ionic events' in the pancreatic β cell. Trends Pharmacol. Sci. 19:496-499.
3. 2+ in rat pancreatic islets. Proc. Natl. Acad. Sci. U. S. A. 92:10728-10732.
4. Straub, S.G., and Sharp, G.W. 2002. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab. Res. Rev. 18:451-463.
5. Nesher, R., and Cerasi, E. 1987. Biphasic insulin release as the expression of combined inhibitory and potentiating effects of glucose. Endocrinology. 121:1017-1024.
6. Grodsky, G.M. 1972. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J. Clin. Invest. 51:2047-2059.
7. Nesher, R., and Cerasi, E. 2002. Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes. 51:S53-S59.
8. Henquin, J.C., Ravier, M.A., Nenquin, M., Jonas, J.C., and Gilon, P. 2003. Hierarchy of the β-cell signals controlling insulin secretion. Eur. J. Clin. Invest. 33:742-750.
9. v2.3 calcium channels control second-phase insulin release. J. Clin. Invest. 115:146-154. doi:10.1172/ JCI200522518.
10. Newcomb, R., et al. 1998. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 37:15353-15362.
11. 2+ channel null mice. EMBO J. 22:3844-3854.
12. + channels of chromaffin cells. Eur. J. Pharmacol. 475:11-18.
13. 2+ channels in pancreatic β cells. Proc. Natl. Acad. Sci. U. S. A. 96:10164-10169.
14. 2+ channels by distinct domains within SNAP-25. Diabetes. 51:1425-1436.
15. 2+ channel is functionally coupled to the exocytotic machinery. Proc. Natl. Acad. Sci. U. S. A. 96:248-253.
16. Straub, S.G., and Sharp, G.W. 2004. Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion. Am. J. Physiol. Cell Physiol. 287:C565-C571.
17. 2+ oscillation frequency and insulin exocytosis. Cell. 119:273-284.
18. 2+ spike frequency can optimize gene expression. Nature. 392:936-941.
19. Bonner-Weir, S. 2000. Perspective: Postnatal pancreatic beta cell growth. Endocrinology. 141:1926-1929.
20. 2+ influx in insulin-secreting cells. J. Biol. Chem. 279:19396-19400.
21. 2+ entry. J. Biol. Chem. 275:40187-40194.
22. Parker, P.J., and Murray-Rust, J. 2004. PKC at a glance. J. Cell. Sci. 117:131-132.
23. 2+ channels. J. Biol. Chem. 269:2743-2749.
24. Eliasson, L., et al. 1996. PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic β cells. Science. 271:813-815.
25. 2+ concentration and insulin secretion as evidenced from measurements in mouse single pancreatic islets. Proc. Natl. Acad. Sci. U. S. A. 92:9712-9716.
26. Mendez, C.F., et al. 2003. Rapid association of protein kinase Cε with insulin granules is essential for insulin exocytosis. J. Biol. Chem. 278:44753-44757.
27. Perander, M., Bjorkoy, G., and Johansen, T. 2001. Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase Cλ. J. Biol. Chem. 276:13015-13024.
28. Harris, T.E., Persaud, S.J., and Jones, P.M. 1996. Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors. Biochem. Biophys. Res. Commun. 227:672-676.
29. Furukawa, N., et al. 1999. Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulin gene: DNA-binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) are enhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway. Endocr. J. 46:43-58.
30. Way, K.J., Chou, E., and King, G.L. 2000. Identification of PKC-isoform-specific biological actions using pharmacological approaches. Trends Pharmacol. Sci. 21:181-187.
31. Hashimoto, N., et al. 2005. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells. J. Clin. Invest. 115:138-145. doi:10.1172/JCI200522232.
32. + channels and diabetes mellitus. News Physiol. Sci. 5:143-147.