메뉴 건너뛰기




Volumn 75, Issue 3, 2011, Pages 277-284

New therapeutic options for metastatic malignant insulinomas

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITOR; ALPHA INTERFERON; BEVACIZUMAB; CAPECITABINE; CISPLATIN; DACARBAZINE; DOXORUBICIN; EVEROLIMUS; FLUOROURACIL; FOLINIC ACID; GLUCOSE; SOMATOSTATIN DERIVATIVE; STREPTOZOCIN; SUNITINIB; TEMOZOLOMIDE; THALOMIDE; UNCLASSIFIED DRUG;

EID: 79961243200     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04145.x     Document Type: Review
Times cited : (54)

References (84)
  • 2
    • 1842524986 scopus 로고    scopus 로고
    • Considerations concerning a tailored, individualized therapeutic management of patients with (neuro)endocrine tumours of the gastrointestinal tract and pancreas
    • DOI 10.1677/erc.0.0110019
    • de Herder, W.W., Krenning, E.P., van Eijck, C.H., et al. (2004) Considerations concerning a tailored, individualized therapeutic management of patients with (neuro)endocrine tumours of the gastrointestinal tract and pancreas. Endocrine-Related Cancer, 11, 19-34. (Pubitemid 38419721)
    • (2004) Endocrine-Related Cancer , vol.11 , Issue.1 , pp. 19-34
    • De Herder, W.W.1    Krenning, E.P.2    Van Eijck, C.H.J.3    Lamberts, S.W.J.4
  • 3
    • 78650250772 scopus 로고    scopus 로고
    • Pancreatic endocrine tumors
    • Oberg, K., (2010) Pancreatic endocrine tumors. Seminars in Oncology, 37, 594-618.
    • (2010) Seminars in Oncology , vol.37 , pp. 594-618
    • Oberg, K.1
  • 4
    • 77955211341 scopus 로고    scopus 로고
    • NANETS treatment guidelines: Well-differentiated neuroendocrine tumors of the stomach and pancreas
    • Kulke, M.H., Anthony, L.B., Bushnell, D.L., et al. (2010) NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas, 39, 735-752.
    • (2010) Pancreas , vol.39 , pp. 735-752
    • Kulke, M.H.1    Anthony, L.B.2    Bushnell, D.L.3
  • 7
    • 79251480749 scopus 로고    scopus 로고
    • Surgical management of patients with insulinomas: Result of 292 cases in a single institution
    • Zhao, Y.P., Zhan, H.X., Zhang, T.P., et al. (2011) Surgical management of patients with insulinomas: Result of 292 cases in a single institution. Journal of Surgical Oncology, 103, 169-174.
    • (2011) Journal of Surgical Oncology , vol.103 , pp. 169-174
    • Zhao, Y.P.1    Zhan, H.X.2    Zhang, T.P.3
  • 8
    • 0021732923 scopus 로고
    • Metastatic insulin-secreting carcinoma of the pancreas: Clinical course and the role of surgery
    • Danforth Jr, D.N., Gorden, P., &, Brennan, M.F., (1984) Metastatic insulin-secreting carcinoma of the pancreas: clinical course and the role of surgery. Surgery, 96, 1027-1037.
    • (1984) Surgery , vol.96 , pp. 1027-1037
    • Danforth Jr., D.N.1    Gorden, P.2    Brennan, M.F.3
  • 14
    • 58249123467 scopus 로고    scopus 로고
    • Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours
    • Pape, U.F., Berndt, U., Muller-Nordhorn, J., et al. (2008) Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours. Endocrine-Related Cancer, 15, 1083-1097.
    • (2008) Endocrine-Related Cancer , vol.15 , pp. 1083-1097
    • Pape, U.F.1    Berndt, U.2    Muller-Nordhorn, J.3
  • 15
    • 48249124512 scopus 로고    scopus 로고
    • Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors
    • Pape, U.F., Jann, H., Muller-Nordhorn, J., et al. (2008) Prognostic relevance of a novel TNM classification system for upper gastroenteropancreatic neuroendocrine tumors. Cancer, 113, 256-265.
    • (2008) Cancer , vol.113 , pp. 256-265
    • Pape, U.F.1    Jann, H.2    Muller-Nordhorn, J.3
  • 16
    • 65549124482 scopus 로고    scopus 로고
    • Survival and prognostic factor analysis in patients with metastatic pancreatic endocrine carcinomas
    • Strosberg, J., Gardner, N., &, Kvols, L., (2009) Survival and prognostic factor analysis in patients with metastatic pancreatic endocrine carcinomas. Pancreas, 38, 255-258.
    • (2009) Pancreas , vol.38 , pp. 255-258
    • Strosberg, J.1    Gardner, N.2    Kvols, L.3
  • 18
    • 37449029464 scopus 로고    scopus 로고
    • Gastroenteropancreatic neuroendocrine tumours
    • Modlin, I.M., Oberg, K., Chung, D.C., et al. (2008) Gastroenteropancreatic neuroendocrine tumours. The Lancet Oncology, 9, 61-72.
    • (2008) The Lancet Oncology , vol.9 , pp. 61-72
    • Modlin, I.M.1    Oberg, K.2    Chung, D.C.3
  • 19
    • 77953722069 scopus 로고    scopus 로고
    • The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: A statement
    • Kloppel, G., Rindi, G., Perren, A., et al. (2010) The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Archiv, 456, 595-597.
    • (2010) Virchows Archiv , vol.456 , pp. 595-597
    • Kloppel, G.1    Rindi, G.2    Perren, A.3
  • 21
    • 0017691493 scopus 로고
    • On the mechanism of diazoxide-induced hyperglycemia
    • Altszuler, N., Moraru, E., &, Hampshire, J., (1977) On the mechanism of diazoxide-induced hyperglycemia. Diabetes, 26, 931-935. (Pubitemid 8205502)
    • (1977) Diabetes , vol.26 , Issue.10 , pp. 931-935
    • Altszuler, N.1    Hampshire, J.2    Moraru, E.3
  • 22
    • 0023039535 scopus 로고
    • Diazoxide in the management of patients with insulinoma
    • Goode, P.N., Farndon, J.R., Anderson, J., et al. (1986) Diazoxide in the management of patients with insulinoma. World Journal of Surgery, 10, 586-592. (Pubitemid 16096415)
    • (1986) World Journal of Surgery , vol.10 , Issue.4 , pp. 586-592
    • Goode, P.N.1    Farndon, J.R.2    Anderson, J.3
  • 23
    • 0030695334 scopus 로고    scopus 로고
    • Diazoxide treatment for insulinoma: A national UK survey
    • Gill, G.V., Rauf, O., &, MacFarlane, I.A., (1997) Diazoxide treatment for insulinoma: a national UK survey. Postgraduate Medical Journal, 73, 640-641. (Pubitemid 27464460)
    • (1997) Postgraduate Medical Journal , vol.73 , Issue.864 , pp. 640-641
    • Gill, G.V.1    Rauf, O.2    MacFarlane, I.A.3
  • 25
    • 0015952022 scopus 로고
    • Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin
    • Brodows, R.G., &, Campbell, R.G., (1974) Control of refractory fasting hypoglycemia in a patient with suspected insulinoma with diphenylhydantoin. The Journal of Clinical Endocrinology and Metabolism, 38, 159-162.
    • (1974) The Journal of Clinical Endocrinology and Metabolism , vol.38 , pp. 159-162
    • Brodows, R.G.1    Campbell, R.G.2
  • 28
    • 19744366733 scopus 로고    scopus 로고
    • Octreotide in insulinoma patients: Efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies
    • DOI 10.1530/eje.1.01901
    • Vezzosi, D., Bennet, A., Rochaix, P., et al. (2005) Octreotide in insulinoma patients: efficacy on hypoglycemia, relationships with Octreoscan scintigraphy and immunostaining with anti-sst2A and anti-sst5 antibodies. European Journal of Endocrinology, 152, 757-767. (Pubitemid 40744545)
    • (2005) European Journal of Endocrinology , vol.152 , Issue.5 , pp. 757-767
    • Vezzosi, D.1    Bennet, A.2    Rochaix, P.3    Courbon, F.4    Selves, J.5    Pradere, B.6    Buscail, L.7    Susini, C.8    Caron, P.9
  • 29
    • 43949091479 scopus 로고    scopus 로고
    • Short- and long-term somatostatin analogue treatment in patients with hypoglycaemia related to endogenous hyperinsulinism
    • DOI 10.1111/j.1365-2265.2007.03136.x
    • Vezzosi, D., Bennet, A., Courbon, F., et al. (2008) Short- and long-term somatostatin analogue treatment in patients with hypoglycaemia related to endogenous hyperinsulinism. Clinical Endocrinology (Oxford), 68, 904-911. (Pubitemid 351703950)
    • (2008) Clinical Endocrinology , vol.68 , Issue.6 , pp. 904-911
    • Vezzosi, D.1    Bennet, A.2    Courbon, F.3    Caron, P.4
  • 30
    • 78650958451 scopus 로고    scopus 로고
    • Amelioration of hypoglycemia with octreotide therapy in metastatic insulinoma with positive octreotide scan
    • Wade, A.N., Cheng, G., Teitelbaum, U., et al. (2011) Amelioration of hypoglycemia with octreotide therapy in metastatic insulinoma with positive octreotide scan. Pancreas, 40, 173-175.
    • (2011) Pancreas , vol.40 , pp. 173-175
    • Wade, A.N.1    Cheng, G.2    Teitelbaum, U.3
  • 32
    • 69749110763 scopus 로고    scopus 로고
    • ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biotherapy
    • Oberg, K., Ferone, D., Kaltsas, G., et al. (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: biotherapy. Neuroendocrinology, 90, 209-213.
    • (2009) Neuroendocrinology , vol.90 , pp. 209-213
    • Oberg, K.1    Ferone, D.2    Kaltsas, G.3
  • 33
    • 0037233574 scopus 로고    scopus 로고
    • Expression of somatostatin receptor subtypes 1 to 5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors
    • DOI 10.1385/MO:20:1:59
    • Fjallskog, M.L., Ludvigsen, E., Stridsberg, M., et al. (2003) Expression of somatostatin receptor subtypes 1 to 5 in tumor tissue and intratumoral vessels in malignant endocrine pancreatic tumors. Medical Oncology, 20, 59-67. (Pubitemid 36344027)
    • (2003) Medical Oncology , vol.20 , Issue.1 , pp. 59-67
    • Fjallskog, M.-L.1    Ludvigsen, E.2    Stridsberg, M.3    Oberg, K.4    Eriksson, B.5    Janson, E.T.6
  • 34
    • 35348834750 scopus 로고    scopus 로고
    • Differential expression of the five somatostatin receptor subtypes in human benign and malignant insulinomas - Predominance of receptor subtype 4
    • DOI 10.1007/s12022-007-0014-8
    • Portela-Gomes, G.M., Stridsberg, M., Grimelius, L., et al. (2007) Differential expression of the five somatostatin receptor subtypes in human benign and malignant insulinomas-predominance of receptor subtype 4. Endocrine Pathology, 18, 79-85. (Pubitemid 47574991)
    • (2007) Endocrine Pathology , vol.18 , Issue.2 , pp. 79-85
    • Portela-Gomes, G.M.1    Stridsberg, M.2    Grimelius, L.3    Rorstad, O.4    Janson, E.T.5
  • 35
    • 34447094133 scopus 로고    scopus 로고
    • Severe hypoglycaemia after long-acting octreotide in a patient with an unrecognized malignant insulinoma
    • DOI 10.1111/j.1445-5994.2007.01371.x
    • Healy, M.L., Dawson, S.J., Murray, R.M., et al. (2007) Severe hypoglycaemia after long-acting octreotide in a patient with an unrecognized malignant insulinoma. Internal Medicine Journal, 37, 406-409. (Pubitemid 47029891)
    • (2007) Internal Medicine Journal , vol.37 , Issue.6 , pp. 406-409
    • Healy, M.L.1    Dawson, S.J.2    Murray, R.M.L.3    Zalcberg, J.4    Jefford, M.5
  • 36
    • 0033567934 scopus 로고    scopus 로고
    • Failure to confirm major objective antitumor activity for streptozocin and doxorubicin in the treatment of patients with advanced islet cell carcinoma
    • DOI 10.1002/(SICI)1097-0142(19990915)86:6<944::AID-CNCR8>3.0.CO;2-P
    • Cheng, P.N., &, Saltz, L.B., (1999) Failure to confirm major objective antitumor activity for streptozocin and doxorubicin in the treatment of patients with advanced islet cell carcinoma. Cancer, 86, 944-948. (Pubitemid 29439847)
    • (1999) Cancer , vol.86 , Issue.6 , pp. 944-948
    • Cheng, P.N.M.1    Saltz, L.B.2
  • 37
    • 69749117558 scopus 로고    scopus 로고
    • ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Chemotherapy in patients with neuroendocrine tumors
    • Eriksson, B., Annibale, B., Bajetta, E., et al. (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: chemotherapy in patients with neuroendocrine tumors. Neuroendocrinology, 90, 214-219.
    • (2009) Neuroendocrinology , vol.90 , pp. 214-219
    • Eriksson, B.1    Annibale, B.2    Bajetta, E.3
  • 38
    • 0023433982 scopus 로고
    • Karnofsky memorial lecture. An odyssey in the land of small tumors
    • Moertel, C.G., (1987) Karnofsky memorial lecture. An odyssey in the land of small tumors. Journal of Clinical Oncology, 5, 1502-1522.
    • (1987) Journal of Clinical Oncology , vol.5 , pp. 1502-1522
    • Moertel, C.G.1
  • 39
    • 0019215383 scopus 로고
    • Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma
    • Moertel, C.G., Hanley, J.A., &, Johnson, L.A., (1980) Streptozocin alone compared with streptozocin plus fluorouracil in the treatment of advanced islet-cell carcinoma. The New England Journal of Medicine, 303, 1189-1194. (Pubitemid 11207582)
    • (1980) New England Journal of Medicine , vol.303 , Issue.21 , pp. 1189-1194
    • Moertel, C.G.1    Hanley, J.A.2    Johnson, L.A.3
  • 40
    • 0026530547 scopus 로고
    • Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma
    • Moertel, C.G., Lefkopoulo, M., Lipsitz, S., et al. (1992) Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma. The New England Journal of Medicine, 326, 519-523.
    • (1992) The New England Journal of Medicine , vol.326 , pp. 519-523
    • Moertel, C.G.1    Lefkopoulo, M.2    Lipsitz, S.3
  • 42
    • 0036015230 scopus 로고    scopus 로고
    • Treatment of malignant endocrine pancreatic tumors with a combination of α-interferon and somatostatin analogs
    • DOI 10.1385/MO:19:1:35
    • Fjallskog, M.L., Sundin, A., Westlin, J.E., et al. (2002) Treatment of malignant endocrine pancreatic tumors with a combination of alpha-interferon and somatostatin analogs. Medical Oncology, 19, 35-42. (Pubitemid 34587755)
    • (2002) Medical Oncology , vol.19 , Issue.1 , pp. 35-42
    • Fjallskog, M.-L.1    Sundin, A.2    Westlin, J.-E.3    Oberg, K.4    Janson, E.T.5    Eriksson, B.6
  • 43
    • 47549101659 scopus 로고    scopus 로고
    • Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors
    • DOI 10.1159/000117575
    • Fjallskog, M.L., Janson, E.T., Falkmer, U.G., et al. (2008) Treatment with combined streptozotocin and liposomal doxorubicin in metastatic endocrine pancreatic tumors. Neuroendocrinology, 88, 53-58. (Pubitemid 352009119)
    • (2008) Neuroendocrinology , vol.88 , Issue.1 , pp. 53-58
    • Fjallskog, M.-L.H.1    Janson, E.T.2    Falkmer, U.G.3    Vatn, M.H.4    Oberg, K.E.5    Eriksson, B.K.6
  • 44
    • 78349309297 scopus 로고    scopus 로고
    • Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma
    • Chandra, P., Yarandi, S.S., Khazai, N., et al. (2010) Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma. American Journal of the Medical Sciences, 340, 414-417.
    • (2010) American Journal of the Medical Sciences , vol.340 , pp. 414-417
    • Chandra, P.1    Yarandi, S.S.2    Khazai, N.3
  • 45
    • 33747338238 scopus 로고    scopus 로고
    • Malignant insulinomas with hepatic metastases successfully treated with selective internal radiation therapy
    • Ho, K.W., Wong, C.C., Balalla, B., et al. (2006) Malignant insulinomas with hepatic metastases successfully treated with selective internal radiation therapy. Clinical Endocrinology (Oxford), 65, 410-411.
    • (2006) Clinical Endocrinology (Oxford) , vol.65 , pp. 410-411
    • Ho, K.W.1    Wong, C.C.2    Balalla, B.3
  • 47
    • 55249106658 scopus 로고    scopus 로고
    • Aggressive surgical resection in the management of pancreatic neuroendocrine tumors: When is it indicated?
    • Hodul, P.J., Strosberg, J.R., &, Kvols, L.K., (2008) Aggressive surgical resection in the management of pancreatic neuroendocrine tumors: when is it indicated? Cancer Control, 15, 314-321.
    • (2008) Cancer Control , vol.15 , pp. 314-321
    • Hodul, P.J.1    Strosberg, J.R.2    Kvols, L.K.3
  • 49
    • 69749089515 scopus 로고    scopus 로고
    • ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Peptide receptor radionuclide therapy with radiolabeled somatostatin analogs
    • Kwekkeboom, D.J., Krenning, E.P., Lebtahi, R., et al. (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: peptide receptor radionuclide therapy with radiolabeled somatostatin analogs. Neuroendocrinology, 90, 220-226.
    • (2009) Neuroendocrinology , vol.90 , pp. 220-226
    • Kwekkeboom, D.J.1    Krenning, E.P.2    Lebtahi, R.3
  • 50
    • 74849111472 scopus 로고    scopus 로고
    • Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors
    • Kwekkeboom, D.J., de Herder, W.W., van Eijck, C.H., et al. (2010) Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors. Seminars in Nuclear Medicine, 40, 78-88.
    • (2010) Seminars in Nuclear Medicine , vol.40 , pp. 78-88
    • Kwekkeboom, D.J.1    De Herder, W.W.2    Van Eijck, C.H.3
  • 51
    • 79951732688 scopus 로고    scopus 로고
    • Somatostatin receptor-targeted radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors
    • Kwekkeboom, D.J., de Herder, W.W., &, Krenning, E.P., (2011) Somatostatin receptor-targeted radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors. Endocrinology & Metabolism Clinics of North America, 40, 173-185.
    • (2011) Endocrinology & Metabolism Clinics of North America , vol.40 , pp. 173-185
    • Kwekkeboom, D.J.1    De Herder, W.W.2    Krenning, E.P.3
  • 53
    • 14644413806 scopus 로고    scopus 로고
    • Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas
    • Kouvaraki, M.A., Ajani, J.A., Hoff, P., et al. (2004) Fluorouracil, doxorubicin, and streptozocin in the treatment of patients with locally advanced and metastatic pancreatic endocrine carcinomas. Journal of Clinical Oncology, 22, 4762-4771.
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 4762-4771
    • Kouvaraki, M.A.1    Ajani, J.A.2    Hoff, P.3
  • 54
    • 0026095401 scopus 로고
    • Metastatic carcinoid and islet cell tumours of the pancreas: A phase II trial of the efficacy of combination chemotherapy with 5-fluorouracil, doxorubicin and cisplatin
    • Rougier, P., Oliveira, J., Ducreux, M., et al. (1991) Metastatic carcinoid and islet cell tumours of the pancreas: a phase II trial of the efficacy of combination chemotherapy with 5-fluorouracil, doxorubicin and cisplatin. European Journal of Cancer, 27, 1380-1382.
    • (1991) European Journal of Cancer , vol.27 , pp. 1380-1382
    • Rougier, P.1    Oliveira, J.2    Ducreux, M.3
  • 55
    • 0031889760 scopus 로고    scopus 로고
    • Doxorubicin, streptozocin, and 5-fluorouracil chemotherapy for patients with metastatic islet-cell carcinoma
    • DOI 10.1097/00000421-199802000-00008
    • Rivera, E., &, Ajani, J.A., (1998) Doxorubicin, streptozocin, and 5-fluorouracil chemotherapy for patients with metastatic islet-cell carcinoma. American Journal of Clinical Oncology, 21, 36-38. (Pubitemid 28092969)
    • (1998) American Journal of Clinical Oncology: Cancer Clinical Trials , vol.21 , Issue.1 , pp. 36-38
    • Rivera, E.1    Ajani, J.A.2
  • 56
    • 77950367451 scopus 로고    scopus 로고
    • Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours
    • Turner, N.C., Strauss, S.J., Sarker, D., et al. (2010) Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours. British Journal of Cancer, 102, 1106-1112.
    • (2010) British Journal of Cancer , vol.102 , pp. 1106-1112
    • Turner, N.C.1    Strauss, S.J.2    Sarker, D.3
  • 57
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer, E.A., Therasse, P., Bogaerts, J., et al. (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). European Journal of Cancer, 45, 228-247.
    • (2009) European Journal of Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 58
    • 57849110449 scopus 로고    scopus 로고
    • Individual patient data analysis to assess modifications to the RECIST criteria
    • Bogaerts, J., Ford, R., Sargent, D., et al. (2009) Individual patient data analysis to assess modifications to the RECIST criteria. European Journal of Cancer, 45, 248-260.
    • (2009) European Journal of Cancer , vol.45 , pp. 248-260
    • Bogaerts, J.1    Ford, R.2    Sargent, D.3
  • 59
    • 78650993549 scopus 로고    scopus 로고
    • First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
    • Strosberg, J.R., Fine, R.L., Choi, J., et al. (2011) First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer, 117, 268-275.
    • (2011) Cancer , vol.117 , pp. 268-275
    • Strosberg, J.R.1    Fine, R.L.2    Choi, J.3
  • 60
    • 0034823957 scopus 로고    scopus 로고
    • Phase II trial dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282
    • DOI 10.1023/A:1011632713360
    • Ramanathan, R.K., Cnaan, A., Hahn, R.G., et al. (2001) Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282. Annals of Oncology, 12, 1139-1143. (Pubitemid 32834496)
    • (2001) Annals of Oncology , vol.12 , Issue.8 , pp. 1139-1143
    • Ramanathan, R.K.1    Cnaan, A.2    Hahn, R.G.3    Carbone, P.P.4    Haller, D.G.5
  • 61
    • 34547143614 scopus 로고    scopus 로고
    • Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapy
    • DOI 10.1159/000102969
    • Strosberg, J., Hoffe, S., Gardner, N., et al. (2007) Effective treatment of locally advanced endocrine tumors of the pancreas with chemoradiotherapy. Neuroendocrinology, 85, 216-220. (Pubitemid 47123456)
    • (2007) Neuroendocrinology , vol.85 , Issue.4 , pp. 216-220
    • Strosberg, J.1    Hoffe, S.2    Gardner, N.3    Choi, J.4    Kvols, L.5
  • 62
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
    • Jiao, Y., Shi, C., Edil, B.H., et al. (2011) DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors. Science 331, 1145-1146.
    • (2011) Science , vol.331 , pp. 1145-1146
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3
  • 64
    • 77953606637 scopus 로고    scopus 로고
    • The potential role of mTOR inhibitors in the treatment of endocrine tumors
    • Grozinsky-Glasberg, S., &, Shimon, I., (2010) The potential role of mTOR inhibitors in the treatment of endocrine tumors. Journal of Endocrinological Investigation, 33, 276-281.
    • (2010) Journal of Endocrinological Investigation , vol.33 , pp. 276-281
    • Grozinsky-Glasberg, S.1    Shimon, I.2
  • 65
    • 79251512978 scopus 로고    scopus 로고
    • MTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours
    • Kasajima, A., Pavel, M., Darb-Esfahani, S., et al. (2011) mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours. Endocrine-Related Cancer, 18, 181-192.
    • (2011) Endocrine-Related Cancer , vol.18 , pp. 181-192
    • Kasajima, A.1    Pavel, M.2    Darb-Esfahani, S.3
  • 66
    • 52049125970 scopus 로고    scopus 로고
    • Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: Results of a phase II study
    • Yao, J.C., Phan, A.T., Chang, D.Z., et al. (2008) Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study. Journal of Clinical Oncology, 26, 4311-4318.
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 4311-4318
    • Yao, J.C.1    Phan, A.T.2    Chang, D.Z.3
  • 67
    • 79851500081 scopus 로고    scopus 로고
    • Everolimus for advanced pancreatic neuroendocrine tumors
    • Yao, J.C., Shah, M.H., Ito, T., et al. (2011) Everolimus for advanced pancreatic neuroendocrine tumors. The New England Journal of Medicine, 364, 514-523.
    • (2011) The New England Journal of Medicine , vol.364 , pp. 514-523
    • Yao, J.C.1    Shah, M.H.2    Ito, T.3
  • 69
    • 0035663898 scopus 로고    scopus 로고
    • Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel
    • DOI 10.1046/j.1463-1326.2001.00150.x
    • Fuhrer, D.K., Kobayashi, M., &, Jiang, H., (2001) Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel. Diabetes, Obesity and Metabolism, 3, 393-402. (Pubitemid 34030857)
    • (2001) Diabetes, Obesity and Metabolism , vol.3 , Issue.6 , pp. 393-402
    • Fuhrer, D.K.1    Kobayashi, M.2    Jiang, H.3
  • 70
    • 33746488875 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: A crossroad between cancer and diabetes?
    • DOI 10.1681/ASN.2006030196
    • di Paolo, S., Teutonico, A., Leogrande, D., et al. (2006) Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: A crossroad between cancer and diabetes? Journal of the American Society of Nephrology, 17, 2236-2244. (Pubitemid 44141914)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.8 , pp. 2236-2244
    • Di Paolo, S.1    Teutonico, A.2    Leogrande, D.3    Capobianco, C.4    Schena, P.F.5
  • 71
    • 42449104351 scopus 로고    scopus 로고
    • MTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • Fraenkel, M., Ketzinel-Gilad, M., Ariav, Y., et al. (2008) mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes, 57, 945-957.
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3
  • 72
    • 58149385408 scopus 로고    scopus 로고
    • Glycemic control in patients with insulinoma treated with everolimus
    • Kulke, M.H., Bergsland, E.K., &, Yao, J.C., (2009) Glycemic control in patients with insulinoma treated with everolimus. The New England Journal of Medicine, 360, 195-197.
    • (2009) The New England Journal of Medicine , vol.360 , pp. 195-197
    • Kulke, M.H.1    Bergsland, E.K.2    Yao, J.C.3
  • 73
    • 79961224607 scopus 로고    scopus 로고
    • Everolimus Resolves Hypoglycemia, Produces Hyperglycemia and Insulin Usage in a Diabetic Patient with Non-Resectable Malignant Insulinoma
    • Ferrer-Garcia, J.C., Tolosa-Torrens, M., Hernando-Melia, C., et al. (2011) Everolimus Resolves Hypoglycemia, Produces Hyperglycemia and Insulin Usage in a Diabetic Patient with Non-Resectable Malignant Insulinoma. Endocrine Practice, 17, 1-11.
    • (2011) Endocrine Practice , vol.17 , pp. 1-11
    • Ferrer-Garcia, J.C.1    Tolosa-Torrens, M.2    Hernando-Melia, C.3
  • 74
    • 69949100179 scopus 로고    scopus 로고
    • Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
    • Bourcier, M.E., Sherrod, A., DiGuardo, M., et al. (2009) Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases. Journal of Clinical Endocrinology and Metabolism, 94, 3157-3162.
    • (2009) Journal of Clinical Endocrinology and Metabolism , vol.94 , pp. 3157-3162
    • Bourcier, M.E.1    Sherrod, A.2    Diguardo, M.3
  • 75
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • DOI 10.1200/JCO.2005.07.093
    • Pietras, K., &, Hanahan, D., (2005) A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. Journal of Clinical Oncology, 23, 939-952. (Pubitemid 46202314)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.5 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 76
    • 79851482955 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
    • Raymond, E., Dahan, L., Raoul, J.L., et al. (2011) Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. The New England Journal of Medicine, 364, 501-513.
    • (2011) The New England Journal of Medicine , vol.364 , pp. 501-513
    • Raymond, E.1    Dahan, L.2    Raoul, J.L.3
  • 78
    • 33644803255 scopus 로고    scopus 로고
    • Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: Lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography
    • Korner, M., Eltschinger, V., Waser, B., et al. (2005) Value of immunohistochemistry for somatostatin receptor subtype sst2A in cancer tissues: lessons from the comparison of anti-sst2A antibodies with somatostatin receptor autoradiography. American Journal of Surgical Pathology, 29, 1642-1651.
    • (2005) American Journal of Surgical Pathology , vol.29 , pp. 1642-1651
    • Korner, M.1    Eltschinger, V.2    Waser, B.3
  • 79
    • 79953202924 scopus 로고    scopus 로고
    • Immunhistochemische Beurteilung von Somatostatinrezeptorsubtypen im Entnahmematerial neuroendokriner Tumoren
    • Sasano, H., Iida, S., &, Kasajima, A., (2010) Immunhistochemische Beurteilung von Somatostatinrezeptorsubtypen im Entnahmematerial neuroendokriner Tumoren. Der Pathologe, 31 (Suppl 2), 199-203.
    • (2010) Der Pathologe , vol.31 , Issue.SUPPL. 2 , pp. 199-203
    • Sasano, H.1    Iida, S.2    Kasajima, A.3
  • 80
    • 0037323565 scopus 로고    scopus 로고
    • The pathophysiological consequences of somatostatin receptor internalization and resistance
    • DOI 10.1210/er.2000-0001
    • Hofland, L.J., &, Lamberts, S.W., (2003) The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocrine Reviews, 24, 28-47. (Pubitemid 36223278)
    • (2003) Endocrine Reviews , vol.24 , Issue.1 , pp. 28-47
    • Hofland, L.J.1    Lamberts, S.W.J.2
  • 81
    • 77951654565 scopus 로고    scopus 로고
    • Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma
    • Ong, G.S., Henley, D.E., Hurley, D., et al. (2010) Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma. European Journal of Endocrinology, 162, 1001-1008.
    • (2010) European Journal of Endocrinology , vol.162 , pp. 1001-1008
    • Ong, G.S.1    Henley, D.E.2    Hurley, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.