Phosphoethanolamine transferase LptA in haemophilus ducreyi modifies lipid a and contributes to human defensin resistance in vitro

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Trombley, Michael P ^a,c   Post, Deborah M B ^b   Rinker, Sherri D ^a,d   Reinders, Lorri M ^b   Fortney, Kate R ^a   Zwickl, Beth W ^a   Janowicz, Diane M ^a   Baye, Fitsum M ^a   Katz, Barry P ^a   Spinola, Stanley M ^a   Bauer, Margaret E ^a  

^a INDIANA UNIVERSITY   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c BUTLER UNIVERSITY   (United States)

^d AIT Bioscience   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; BETA DEFENSIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CIPROFLOXACIN; DEFENSIN; ETHANOLAMINE PHOSPHOTRANSFERASE; LIPID A; LIPOOLIGOSACCHARIDE; LIPOPOLYSACCHARIDE; PHOSPHOETHANOLAMINE; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERIAL PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; ETHANOLAMINE DERIVATIVE; PROTEIN BINDING;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL MUTANT; CELL SURFACE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVITY; FEMALE; GENE; GENE FUNCTION; GENETIC COMPLEMENTATION; HAEMOPHILUS DUCREYI; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; LPTA GENE; MALE; MASS SPECTROMETRY; NONHUMAN; NORMAL HUMAN; PTDA GENE; PTDB GENE; SINGLE DRUG DOSE; ADULT; CHANCROID; CHEMISTRY; DRUG EFFECTS; GENE DELETION; GENE EXPRESSION; GENETICS; METABOLISM; MICROBIOLOGY; MUTATION; ORAL DRUG ADMINISTRATION; PATHOGENICITY; PATHOLOGY; STATIC ELECTRICITY;

BACTERIA (MICROORGANISMS); HAEMOPHILUS DUCREYI; NEGIBACTERIA;

ADMINISTRATION, ORAL; ADULT; ALPHA-DEFENSINS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL PROTEINS; BETA-DEFENSINS; CHANCROID; CIPROFLOXACIN; DRUG RESISTANCE, BACTERIAL; ETHANOLAMINEPHOSPHOTRANSFERASE; ETHANOLAMINES; FEMALE; GENE DELETION; GENE EXPRESSION; GENETIC COMPLEMENTATION TEST; HAEMOPHILUS DUCREYI; HEALTHY VOLUNTEERS; HUMANS; LIPID A; MALE; MUTATION; PROTEIN BINDING; STATIC ELECTRICITY;

EID: 84930678870     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0124373     Document Type: Article

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