Non-invasive vulnerable plaque imaging: Howdowe know that treatmentworks?

European Heart Journal Cardiovascular Imaging

Volumn 15, Issue 11, 2014, Pages 1194-1202

  Sannino, Anna ^a   Brevetti, Linda ^a   Giugliano, Giuseppe ^a   Scudiero, Fernando ^a   Toscano, Evelina ^a   Mainolfi, Ciro ^a   Cuocolo, Alberto ^a   Perrino, Cinzia ^a   Stabile, Eugenio ^a   Trimarco, Bruno ^a   Esposito, Giovanni ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Atherosclerosis; Cardiovascular risk; Cardiovascular treatment; Non invasive imaging; Vulnerable plaque

Indexed keywords

ATHEROSCLEROSIS; CARDIAC IMAGING; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; ECHOGRAPHY; HUMAN; IMMUNOSCINTIGRAPHY; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TREATMENT RESPONSE; VULNERABLE POPULATION; CORONARY ARTERY DISEASE; PATHOLOGY; PLAQUE, ATHEROSCLEROTIC; RISK ASSESSMENT;

CORONARY ARTERY DISEASE; DIAGNOSTIC IMAGING; HUMANS; PLAQUE, ATHEROSCLEROTIC; RISK ASSESSMENT;

EID: 84930670102     PISSN: 20472404     EISSN: 20472412     Source Type: Journal    
DOI: 10.1093/ehjci/jeu097     Document Type: Review

References (102)

1. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation 1995;92:657-71.
2. Golledge J, Greenhalgh RM, Davies AH. The symptomatic carotid plaque. Stroke 2000;31:774-81.
3. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and highrisk plaque: part I: evolving concepts. J Am Coll Cardiol 2005;46:937-54.
4. Fayad ZA, Fuster V. Clinical imaging of the high-risk or vulnerable atherosclerotic plaque. Circ Res 2001;89:305-16.
5. Johnston SC, Gress DR, Browner WS, Sidney S. Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000;284:2901-6.
6. Fuster V, Kim RJ. Frontiers in cardiovascular magnetic resonance. Circulation 2005; 112:135-44.
7. Gertow K, Nobili E, Folkersen L,NewmanJW, Pedersen TL, Ekstrand J et al. 12-and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms. Atherosclerosis 2011;215:411-6.
8. Shibata N, Glass CK. Regulation of macrophage function in inflammation and atherosclerosis. J Lipid Res 2009;50 (Suppl):S277-281.
9. Naghavi M, Libby P, Falk E, CasscellsSW, Litovsky S, Rumberger J et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation 2003;108:1664-72.
10. Naghavi M, Libby P, Falk E, CasscellsSW, Litovsky S, Rumberger J et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation 2003;108:1772-8.
11. Lombardo A, Biasucci LM, Lanza GA, Coli S, Silvestri P, CianfloneDet al. Inflammation as a possible link between coronary and carotid plaque instability. Circulation 2004;109:3158-63.
12. Schiano V, Sirico G, Giugliano G, Laurenzano E, Brevetti L, Perrino Cet al. Femoral plaque echogenicity and cardiovascular risk in claudicants. JACC Cardiovasc Imaging 2012;5:348-57.
13. Giugliano G, Di Serafino L, Perrino C, Schiano V, Laurenzano E, Cassese S et al. Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease. Int J Cardiol 2013;167: 2566-71.
14. Bural GG, Torigian DA, Chamroonrat W, Houseni M, Chen W, Basu S et al. FDG-PETis an effective imaging modality to detect and quantify age-related atherosclerosis in large arteries. Eur J Nucl Med Mol Imaging 2008;35:562-9.
15. Maron DJ, Fazio S, LintonMF. Current perspectives on statins. Circulation 2000;101: 207-13.
16. Gargiulo G, Giugliano G, Brevetti L, Sannino A, Schiattarella GG, Serino F et al. Use of statins in lower extremity artery disease: a review. BMC Surg 2012;12(Suppl 1): S15.
17. SchiattarellaGG,Perrino C,Magliulo F, Ilardi F, Serino F, TrimarcoVet al. Statins and the elderly: recent evidence and current indications. Aging Clin Exp Res 2012;24: 47-55.
18. Libby P, Aikawa M. Stabilization of atherosclerotic plaques: new mechanisms and clinical targets. Nat Med 2002;8:1257-62.
19. Ostling G, Goncalves I, Wikstrand J, Berglund G, Nilsson J, Hedblad B. Long-term treatment with low-dose metoprolol CR/Xl is associated with increased plaque echogenicity: the beta-blocker cholesterol-lowering asymptomatic plaque study (BCAPS). Atherosclerosis 2011;215:440-5.
20. Suzuki T, Nozawa T, Fujii N, Sobajima M, Ohori T, Shida T et al. Combination therapy of candesartan with statin inhibits progression of atherosclerosis more than statin alone in patients with coronary artery disease. Coron Artery Dis 2011; 22:352-8.
21. Lal BK, HobsonRWII, Pappas PJ, Kubicka R, Hameed M, Chakhtoura EY et al. Pixel distribution analysis of B-mode ultrasound scan images predicts histologic features of atherosclerotic carotid plaques. J Vasc Surg 2002;35:1210-7.
22. Crouse JR III, Craven TE, Hagaman AP, Bond MG. Association of coronary disease with segment-specific intimal-medial thickening of the extracranial carotid artery. Circulation 1995;92:1141-7.
23. Geroulakos G, O'Gorman DJ, Kalodiki E, Sheridan DJ, Nicolaides AN. The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease. Eur Heart J 1994;15:781-5.
24. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med 1999;340:14-22.
25. Kablak-Ziembicka A, Tracz W, Przewlocki T, Pieniazek P, Sokolowski A, Konieczynska M. Association of increased carotid intima-media thickness with the extent of coronary artery disease. Heart 2004;90:1286-90.
26. Sinha AK, Eigenbrodt M, Mehta JL. Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol 2002;17:526-30.
27. Sawayama Y, Shimizu C, Maeda N, Tatsukawa M, Kinukawa N, Koyanagi S et al. Effects of probucol and pravastatin on common carotid atherosclerosis in patients with asymptomatic hypercholesterolemia. Fukuoka atherosclerosis trial (FAST). J Am Coll Cardiol 2002;39:610-6.
28. Furberg CD, Adams HP Jr, Applegate WB, Byington RP, Espeland MA, Hartwell T et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic carotid artery progression study (ACAPS) research group. Circulation 1994;90:1679-87.
29. Taylor AJ, Kent SM, Flaherty PJ, Coyle LC, Markwood TT, Vernalis MN. ARBITER: arterial biology for the investigation of the treatment effects of reducing cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 2002;106:2055-60.
30. Reilly LM, Lusby RJ, Hughes L, Ferrell LD, Stoney RJ, Ehrenfeld WK. Carotid plaque histology using real-time ultrasonography. Clinical and therapeutic implications.Am J Surg 1983;146:188-93.
31. Johnson JM, Kennelly MM, Decesare D, Morgan S, Sparrow A. Natural history of asymptomatic carotid plaque. Arch Surg 1985;120:1010-2.
32. Gray-Weale AC, Graham JC, Burnett JR, Byrne K, Lusby RJ. Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg (Torino) 1988;29:676-81.
33. Carotid artery plaque composition-relationship to clinical presentation and ultrasound b-mode imaging. European carotid plaque study group. Eur J Vasc Endovasc Surg 1995;10:23-30.
34. Gronholdt ML, Wiebe BM, Laursen H, Nielsen TG, Schroeder TV, Sillesen H. Lipid-rich carotid artery plaques appear echolucent on ultrasound B-mode images and may be associated with intraplaque haemorrhage. Eur J Vasc Endovasc Surg 1997;14:439-45.
35. Gronholdt ML. Ultrasound and lipoproteins as predictors of lipid-rich, ruptureprone plaques in the carotid artery. Arterioscler Thromb Vasc Biol 1999;19:2-13.
36. el-Barghouty N, Geroulakos G, Nicolaides A, Androulakis A, Bahal V. Computerassisted carotid plaque characterisation. Eur J Vasc Endovasc Surg 1995;9:389-93.
37. El-Barghouty NM, Levine T, Ladva S, Flanagan A, Nicolaides A. Histological verification of computerised carotid plaque characterisation. Eur J Vasc Endovasc Surg 1996;11:414-6.
38. Liapis CD, Kakisis JD, Kostakis AG. Carotid stenosis: factors affecting symptomatology. Stroke 2001;32:2782-6.
39. Della-Morte D, Moussa I, Elkind MS, Sacco RL, Rundek T. The short-term effect of atorvastatin on carotid plaque morphology assessed by computer-assisted grayscale densitometry: a pilot study. Neurol Res 2011;33:991-4.
40. Kadoglou NP, Gerasimidis T, Moumtzouoglou A, Kapelouzou A, Sailer N, Fotiadis G et al. Intensive lipid-lowering therapy ameliorates novel calcification markers and GSM score in patients with carotid stenosis. Eur J Vasc Endovasc Surg 2008;35:661-8.
41. Yamagami H, Sakaguchi M, Furukado S, Hoshi T, Abe Y, Hougaku H et al. Statin therapy increases carotid plaque echogenicity in hypercholesterolemic patients. Ultrasound Med Biol 2008;34:1353-9.
42. Watanabe K, Sugiyama S, Kugiyama K, Honda O, Fukushima H, Koga H et al. Stabilization of carotid atheroma assessed by quantitative ultrasound analysis in nonhypercholesterolemic patients with coronary artery disease. JAmColl Cardiol 2005;46: 2022-30.
43. Nissen SE, Gurley JC, Grines CL, Booth DC, McClure R, BerkMet al. Intravascular ultrasound assessment of lumen size and wall morphology in normal subjects and patients with coronary artery disease. Circulation 1991;84:1087-99.
44. Nissen SE, Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation 2001;103:604-16.
45. Brezinski ME, Tearney GJ, Bouma BE, Izatt JA, Hee MR, Swanson EA et al. Optical coherence tomography for optical biopsy. Properties and demonstration of vascular pathology. Circulation 1996;93:1206-13.
46. Tearney GJ, Yabushita H, Houser SL, Aretz HT, Jang IK, Schlendorf KH et al. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation 2003;107:113-9.
47. Jang IK, Bouma BE, Kang DH, Park SJ, Park SW, Seung KB et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol 2002;39:604-9.
48. Staub D, Partovi S, Imfeld S, Uthoff H, Baldi T, Aschwanden M et al. Novel applications of contrast-enhanced ultrasound imaging in vascular medicine. Vasa 2013;42: 17-31.
49. van den Oord SC, Ten Kate GL, Akkus Z, Renaud G, Sijbrands EJ, Ten Cate FJ et al. Assessment of subclinical atherosclerosis using contrast-enhanced ultrasound. Eur Heart J Cardiovasc Imaging 2013;14:56-61.
50. WuJ, Leong-Poi H, Bin J, Yang L, Liao Y, Liu Yet al. Efficacy of contrast-enhanced US and magnetic microbubbles targeted to vascular cell adhesion molecule-1 for molecular imaging of atherosclerosis. Radiology 2011;260:463-71.
51. Bettinger T, Bussat P, Tardy I, Pochon S, Hyvelin JM, Emmel P et al. Ultrasound molecular imaging contrast agent binding to both E-and P-selectin in different species. Invest Radiol 2012;47:516-23.
52. Lindner JR. Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography. Nat Rev Cardiol 2009;6:475-81.
53. Lees AM, Lees RS, Schoen FJ, Isaacsohn JL, Fischman AJ, McKusick KA et al. Imaging human atherosclerosis with 99mTc-labeled low density lipoproteins. Arteriosclerosis 1988;8:461-70.
54. Palac RT, Gray LL, Turner FE, Brown PH, Malinow MR, Demots H. Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative. Nucl Med Commun 1989;10:841-50.
55. Uehara A, Isaka Y, Hashikawa K, Kimura K, Kozuka T, Kamada T et al. Iodine-131-labeled fibronectin: potential agent for imaging atherosclerotic lesion and thrombus. J Nucl Med 1988;29:1264-7.
56. Fischman AJ, Rubin RH, Khaw BA, Kramer PB, Wilkinson R, Ahmad M et al. Radionuclide imaging of experimental atherosclerosis with nonspecific polyclonal immunoglobulin g. J Nucl Med 1989;30:1095-100.
57. Miller DD, Boulet AJ, Tio FO, Garcia OJ, Guy DM, McEver RP et al. In vivo technetium-99mS12 antibody imaging of platelet alpha-granules in rabbit endothelial neointimal proliferation after angioplasty. Circulation 1991;83:224-36.
58. Stratton JR, Cerqueira MD, Dewhurst TA, Kohler TR. Imaging arterial thrombosis: comparison of technetium-99m-labeled monoclonal antifibrin antibodies and indium-111-platelets. J Nucl Med 1994;35:1731-7.
59. Greco C, Di Loreto M, Ciavolella M, Banci M, Taurino M, Cerquetani E et al. Immunodetection of human atherosclerotic plaque with 125I-labeled monoclonal antifibrin antibodies. Atherosclerosis 1993;100:133-9.
60. Ciavolella M, Tavolaro R, Taurino M, Di Loreto M, Greco C, Sbarigia E et al. Immunoscintigraphy of atherosclerotic uncomplicated lesions in vivo with a monoclonal antibody against D-dimers of insoluble fibrin. Atherosclerosis 1999;143:171-5.
61. Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002;105:2708-11.
62. Tawakol A, Migrino RQ, Hoffmann U, Abbara S, Houser S, Gewirtz H et al. Noninvasive in vivo measurement of vascular inflammation with F-18 fluorodeoxyglucose positron emission tomography. J Nucl Cardiol 2005;12:294-301.
63. Stolzmann P, Subramanian S, Abdelbaky A, Maurovich-Horvat P, Scheffel H, Tawakol A et al. Complementary value of cardiac FDG PET and CT for the characterization of atherosclerotic disease. Radiographics 2011;31:1255-69.
64. Alexanderson E, Slomka P, ChengV, Meave A, Saldana Y, Garcia-Rojas L et al. Fusion of positron emission tomography and coronary computed tomographic angiography identifies fluorine 18 fluorodeoxyglucose uptake in the left main coronary artery soft plaque. J Nucl Cardiol 2008;15:841-3.
65. Dunphy MP, Freiman A, Larson SM, StraussHW. Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med 2005;46:1278-84.
66. Johnson JL, Baker AH, Oka K, Chan L, Newby AC, Jackson CL et al. Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation 2006;113:2435-44.
67. Rudd JH, Myers KS, Bansilal S, Machac J, Pinto CA, Tong C et al. Atherosclerosis inflammation imaging with 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8.
68. WuYW, Lin MS, Lin YH,Chao CL, Kao HL. Prevalence of concomitant atherosclerotic arterial diseases in patients with significant cervical carotid artery stenosis in Taiwan. Int J Cardiovasc Imaging 2007;23:433-9.
69. Saam T, Rominger A,Wolpers S, Nikolaou K, Rist C, Greif M et al. Association of inflammation of the left anterior descending coronary artery with cardiovascular risk factors, plaque burden and pericardial fat volume: a PET/CT study. Eur J Nucl Med Mol Imaging 2010;37:1203-12.
70. Paulmier B, Duet M, Khayat R, Pierquet-Ghazzar N, Laissy JP, Maunoury C et al. Arterial wall uptake of fluorodeoxyglucose on PET imaging in stable cancer disease patients indicates higher risk for cardiovascular events. J Nucl Cardiol 2008;15:209-17.
71. Lee SJ, On YK, Lee EJ, Choi JY, Kim BT, Lee KH. Reversal of vascular 18F-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction. J Nucl Med 2008;49:1277-82.
72. Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T et al. Application of 18F-FDG PET for monitoring the therapeutic effect of antiinflammatory drugs on stabilization of vulnerable atherosclerotic plaques. J Nucl Med 2006;47: 1845-50.
73. Tahara N, Kai H, Ishibashi M, Nakaura H, Kaida H, Baba K et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006;48:1825-31.
74. Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, Ortiz Get al. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation 2001;104:2051-6.
75. Mitsumori LM, Hatsukami TS, Ferguson MS, Kerwin WS, Cai J, Yuan C. In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques. J Magn Reson Imaging 2003;17:410-20.
76. Yuan C, Zhang SX, Polissar NL, Echelard D, Ortiz G, DavisJWet al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation 2002;105:181-5.
77. Chu B, Kampschulte A, Ferguson MS, Kerwin WS, Yarnykh VL, O'Brien KD et al. Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 2004;35:1079-84.
78. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby Pet al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 2006;114:1504-11.
79. Frias JC, Williams KJ, Fisher EA, Fayad ZA. Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques. JAmChem Soc 2004;126: 16316-17.
80. Amirbekian V, Aguinaldo JG, Amirbekian S, Hyafil F, Vucic E, Sirol M et al. Atherosclerosis and matrix metalloproteinases: experimental molecular MR imaging in vivo. Radiology 2009;251:429-38.
81. Lipinski MJ, Frias JC, Amirbekian V, Briley-Saebo KC, Mani V, Samber D et al. Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis. JACC Cardiovasc Imaging 2009;2:637-47.
82. Spuentrup E, Botnar RM, Wiethoff AJ, Ibrahim T, Kelle S, KatohMet al. MR imaging of thrombi using EP-2104R, a fibrin-specific contrast agent: initial results in patients. Eur Radiol 2008;18:1995-2005.
83. Kooi ME, Cappendijk VC, Cleutjens KB, Kessels AG, Kitslaar PJ, BorgersMet al. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 2003;107:2453-8.
84. Ruehm SG, Corot C, Vogt P, Kolb S, Debatin JF. Magnetic resonance imaging of atherosclerotic plaque with ultrasmall superparamagnetic particles of iron oxide in hyperlipidemic rabbits. Circulation 2001;103:415-22.
85. Botnar RM, Buecker A, Wiethoff AJ, Parsons EC Jr, Katoh M, Katsimaglis G et al. In vivo magnetic resonance imaging of coronary thrombosis using a fibrin-binding molecular magnetic resonance contrast agent. Circulation 2004;110:1463-6.
86. Winter PM, Neubauer AM, Caruthers SD, Harris TD, Robertson JD, Williams TA et al. Endothelial alpha(v)beta3 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vasc Biol 2006;26:2103-9.
87. Moulton KS, Vakili K, Zurakowski D, Soliman M, Butterfield C, Sylvin E et al. Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci USA 2003;100:4736-41.
88. Corti R, Fayad ZA, Fuster V, Worthley SG, Helft G, Chesebro J et al. Effects of lipid-lowering by simvastatin on human atherosclerotic lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Circulation 2001;104:249-52.
89. Corti R, Fuster V, Fayad ZA,Worthley SG, Helft G, Smith Det al. Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' followup by high-resolution noninvasive magnetic resonance imaging. Circulation 2002; 106:2884-7.
90. Zhao XQ, Dong L, Hatsukami T, Phan BA, Chu B, Moore A et al. MR imaging of carotid plaque composition during lipid-lowering therapy a prospective assessment of effect and time course. JACC Cardiovasc Imaging 2011;4:977-86.
91. West AM, Anderson JD, Meyer CH, Epstein FH,Wang H, Hagspiel KD et al. The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. Atherosclerosis 2011;218:156-62.
92. Schroeder S, Kopp AF, Baumbach A, Meisner C, Kuettner A, Georg C et al. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol 2001;37:1430-5.
93. Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM et al. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol 2006;47:1655-62.
94. Hyafil F, Cornily JC, Feig JE, Gordon R, Vucic E, Amirbekian V et al. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat Med 2007;13:636-41.
95. Uehara M, Funabashi N, Mikami Y, Shiina Y, Nakamura K, Komuro I. Quantitative effect of atorvastatin on size and content of non-calcified plaques of coronary arteries 1 year after atorvastatin treatment by multislice computed tomography. Int J Cardiol 2008;130:269-75.
96. Soeda T, Uemura S, Okayama S, Kawakami R, Sugawara Y, NakagawaHet al. Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. Evaluation using dual-source computed tomography. Circ J 2011;75:2621-7.
97. Wu YW, Kao HL, Huang CL, Chen MF, Lin LY, Wang YC et al. The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers. Eur J Nucl Med Mol Imaging 2011;39: 399-407.
98. Ishii H, Nishio M, Takahashi H, Aoyama T, Tanaka M, Toriyama T et al. Comparison of atorvastatin 5 and 20 mg/d for reducing F-18 fluorodeoxyglucose uptake in atherosclerotic plaques on positron emission tomography/computed tomography: a randomized, investigator-blinded, open-label, 6-month study in Japanese adults scheduled for percutaneous coronary intervention. Clin Ther 2011;32:2337-47.
99. Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008; 451:953-7.
100. Figueroa AL, Subramanian SS, Cury RC, TruongQA, Gardecki JA, Tearney GJ et al. Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: a comparison between positron emission tomography activity, plaque morphology, and histopathology. Circ Cardiovasc Imaging 2011; 5:69-77.
101. Fuster V, Fayad ZA, Moreno PR, Poon M, Corti R, Badimon JJ. Atherothrombosis and high-risk plaque: part II: approaches by noninvasive computed tomographic/magnetic resonance imaging. J Am Coll Cardiol 2005;46:1209-18.
102. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 2000;20:1262-75.