Regulation of macrophage function in inflammation and atherosclerosis

Journal of Lipid Research

Volumn 50, Issue SUPPL., 2009, Pages

  Shibata, Norihito ^a   Glass, Christopher K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Lipopolysaccharide; Liver X receptors; Low density lipoprotein

Indexed keywords

CELL RECEPTOR; DNA BINDING PROTEIN; LIVER X RECEPTOR;

ANIMAL; ATHEROSCLEROSIS; HUMAN; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; LIPID METABOLISM; MACROPHAGE; METABOLISM; REVIEW;

ANIMALS; ATHEROSCLEROSIS; DNA-BINDING PROTEINS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LIPID METABOLISM; MACROPHAGES; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 66349130447     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R800063-JLR200     Document Type: Review

References (48)

1. Lusis, A. J. 2000. Atherosclerosis. Nature. 407: 233-241.
2. Ross, R. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340: 115-126.
3. Glass, C. K., and J. L. Witztum. 2001. Atherosclerosis. the road ahead. Cell. 104: 503-516.
4. Brown, M. S., and J. L. Goldstein. 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52: 223-261. (Pubitemid 13030685)
5. Libby, P. 2002. Inflammation in atherosclerosis. Nature. 420: 868-874. (Pubitemid 36019640)
6. Oram, J. F. 2002. ATP-binding cassette transporter A1 and cholesterol trafficking. Curr. Opin. Lipidol. 13: 373-381. (Pubitemid 34831940)
7. Wang, X., H. L. Collins, M. Ranalletta, I. V. Fuki, J. T. Billheimer, G. H. Rothblat, A. R. Tall, and D. J. Rader. 2007. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J. Clin. Invest. 117: 2216-2224. (Pubitemid 47219566)
8. Yvan-Charvet, L., M. Ranalletta, N. Wang, S. Han, N. Terasaka, R. Li, C. Welch, and A. R. Tall. 2007. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J. Clin. Invest. 117: 3900-3908. (Pubitemid 350224099)
9. Hansson, G. K., P. Libby, U. Schonbeck, and Z. Q. Yan. 2002. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ. Res. 91: 281-291. (Pubitemid 34976993)
10. Joseph, S. B., E. McKilligin, L. Pei, M. A. Watson, A. R. Collins, B. A. Laffitte, M. Chen, G. Noh, J. Goodman, G. N. Hagger, et al. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc. Natl. Acad. Sci. USA. 99: 7604-7609. (Pubitemid 34568738)
11. Tangirala, R. K., E. D. Bischoff, S. B. Joseph, B. L. Wagner, R. Walczak, B. A. Laffitte, C. L. Daige, D. Thomas, R. A. Heyman, D. J. Mangelsdorf, et al. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc. Natl. Acad. Sci. USA. 99: 11896-11901. (Pubitemid 34994495)
12. Teupser, D., D. Kretzschmar, C. Tennert, R. Burkhardt, W. Wilfert, D. Fengler, R. Naumann, A. E. Sippel, and J. Thiery. 2008. Effect of macrophage overexpression of murine liver X receptor-a (LXR-a) on atherosclerosis in LDL-receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 28: 2009-2015.
13. Duarte, J., G. Perriere, V. Laudet, and M. Robinson-Rechavi. 2002. NUREBASE: database of nuclear hormone receptors. Nucleic Acids Res. 30: 364-368. (Pubitemid 34679586)
14. Ogawa, S., J. Lozach, C. Benner, G. Pascual, R. K. Tangirala, S.Westin, A. Hoffmann, S. Subramaniam, M. David, M. G. Rosenfeld, et al. 2005. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 122: 707-721. (Pubitemid 41242636)
15. Glass, C. K., and S. Ogawa. 2006. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat. Rev. Immunol. 6: 44-55. (Pubitemid 43279752)
16. Bonta, P. I., C. M. van Tiel, M. Vos, T. W. Pols, J. V. van Thienen, V. Ferreira, E. K. Arkenbout, J. Seppen, C. A. Spek, T. van der Poll, et al. 2006. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler. Thromb. Vasc. Biol. 26: 2288-2294. (Pubitemid 44465724)
17. Repa, J. J., and D. J. Mangelsdorf. 2002. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8: 1243-1248. (Pubitemid 35373555)
18. Tontonoz, P., and D. J. Mangelsdorf. 2003. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17: 985-993. (Pubitemid 36683707)
19. Janowski, B. A., P. J.Willy, T. R. Devi, J. R. Falck, and D. J.Mangelsdorf. 1996. An oxysterol signalling pathway mediated by the nuclear receptor LXRa. Nature. 383: 728-731. (Pubitemid 26360651)
20. Lehmann, J. M., S. A. Kliewer, L. B. Moore, T. A. Smith-Oliver, B. B. Oliver, J. L. Su, S. S. Sundseth, D. A. Winegar, D. E. Blanchard, T. A. Spencer, et al. 1997. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J. Biol. Chem. 272: 3137-3140. (Pubitemid 27066798)
21. Rigamonti, E., L. Helin, S. Lestavel, A. L. Mutka, M. Lepore, C. Fontaine, M. A. Bouhlel, S. Bultel, J. C. Fruchart, E. Ikonen, et al. 2005. Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages. Circ. Res. 97: 682-689. (Pubitemid 41416337)
22. Joseph, S. B., A. Castrillo, B. A. Laffitte, D. J. Mangelsdorf, and P. Tontonoz. 2003. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat. Med. 9: 213-219. (Pubitemid 36227724)
23. Ghisletti, S.,W. Huang, S. Ogawa, G. Pascual, M. E. Lin, T. M. Willson, M. G. Rosenfeld, and C. K. Glass. 2007. Parallel SUMOylationdependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARg. Mol. Cell. 25: 57-70. (Pubitemid 46049061)
24. Marathe, C., M. N. Bradley, C. Hong, F. Lopez, C. M. Ruiz de Galarreta, P. Tontonoz, and A. Castrillo. 2006. The arginase II gene is an anti-inflammatory target of liver X receptor in macrophages. J. Biol. Chem. 281: 32197-32206. (Pubitemid 46036774)
25. Binder, C. J., M. K. Chang, P. X. Shaw, Y. I. Miller, K. Hartvigsen, A. Dewan, and J. L. Witztum. 2002. Innate and acquired immunity in atherogenesis. Nat. Med. 8: 1218-1226. (Pubitemid 35373552)
26. Chow, J. C., D. W. Young, D. T. Golenbock, W. J. Christ, and F. Gusovsky. 1999. Toll-like receptor-4 mediates lipopolysaccharideinduced signal transduction. J. Biol. Chem. 274: 10689-10692.
27. Yang, R. B., M. R. Mark, A. Gray, A. Huang, M. H. Xie, M. Zhang, A. Goddard, W. I. Wood, A. L. Gurney, and P. J. Godowski. 1998. Tolllike receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature. 395: 284-288. (Pubitemid 28447554)
28. Bjorkbacka, H., V. V. Kunjathoor, K. J. Moore, S. Koehn, C. M. Ordija, M. A. Lee, T. Means, K. Halmen, A. D. Luster, D. T. Golenbock, et al. 2004. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. 10: 416-421. (Pubitemid 38508522)
29. Mullick, A. E., P. S. Tobias, and L. K. Curtiss. 2005. Modulation of atherosclerosis in mice by Toll-like receptor 2. J. Clin. Invest. 115: 3149-3156. (Pubitemid 41567579)
30. Edfeldt, K., J. Swedenborg, G. K. Hansson, and Z. Q. Yan. 2002. Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation. 105: 1158-1161. (Pubitemid 34225814)
31. Moazed, T. C., L. A. Campbell, M. E. Rosenfeld, J. T. Grayston, and C. C. Kuo. 1999. Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. J. Infect. Dis. 180: 238-241. (Pubitemid 29293945)
32. Alber,D. G., K. L. Powell, P. Vallance, D. A.Goodwin, andC. Grahame- Clarke. 2000. Herpesvirus infection accelerates atherosclerosis in the apolipoprotein E-deficient mouse. Circulation. 102: 779-785. (Pubitemid 30648767)
33. Funk, J. L., K. R. Feingold, A. H. Moser, and C. Grunfeld. 1993. Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation. Atherosclerosis. 98: 67-82. (Pubitemid 23010425)
34. Underhill, D. M., and A. Ozinsky. 2002. Toll-like receptors: key mediators of microbe detection. Curr. Opin. Immunol. 14: 103-110. (Pubitemid 34085113)
35. Eggesbo, J. B., T. Lyberg, T. Aspelin, I. Hjermann, and P. Kierulf. 1996. Different binding of 125I-LPS to plasma proteins from persons with high or low HDL. Scand. J. Clin. Lab. Invest. 56: 533-543. (Pubitemid 26342638)
36. Levels, J. H., J. A. Marquart, P. R. Abraham, A. E. van den Ende, H. O. Molhuizen, S. J. van Deventer, and J. C. Meijers. 2005. Lipopolysaccharide is transferred from high-density to low-density lipoproteins by lipopolysaccharide-binding protein and phospholipid transfer protein. Infect. Immun. 73: 2321-2326. (Pubitemid 40470834)
37. Memon, R. A., C. Grunfeld, A. H. Moser, and K. R. Feingold. 1993. Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice. Endocrinology. 132: 2246-2253. (Pubitemid 23133278)
38. Feingold, K. R., I. Hardardottir, R. Memon, E. J. Krul, A. H. Moser, J. M. Taylor, and C. Grunfeld. 1993. Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters. J. Lipid Res. 34: 2147-2158. (Pubitemid 24000962)
39. Posokhova, E. N., O. M. Khoshchenko, M. I. Chasovskikh, E. N. Pivovarova, and M. I. Dushkin. 2008. Lipid synthesis in macrophages during inflammation in vivo: effect of agonists of peroxisome proliferator activated receptors a and g and of retinoid X receptors. Biochemistry. 73: 296-304. (Pubitemid 351490978)
40. Tamura, Y., J. Osuga, H. Adachi, R. Tozawa, Y. Takanezawa, K. Ohashi, N. Yahagi, M. Sekiya, H. Okazaki, S. Tomita, et al. 2004. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J. Biol. Chem. 279: 30938-30944. (Pubitemid 39037752)
41. Buhman, K. F., M. Accad, and R. V. Farese. 2000. Mammalian acyl- CoA:cholesterol acyltransferases. Biochim. Biophys. Acta. 1529: 142-154.
42. Kennedy, M. A., G. C. Barrera, K. Nakamura, A. Baldan, P. Tarr, M. C. Fishbein, J. Frank, O. L. Francone, and P. A. Edwards. 2005. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metab. 1: 121-131. (Pubitemid 43977167)
43. Wang, N., D. Lan, W. Chen, F. Matsuura, and A. R. Tall. 2004. ATPbinding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl. Acad. Sci. USA. 101: 9774-9779. (Pubitemid 38869312)
44. Baranova, I., T. Vishnyakova, A. Bocharov, Z. Chen, A. T. Remaley, J. Stonik, T. L. Eggerman, and A. P. Patterson. 2002. Lipopolysaccharide down regulates both scavenger receptor B1 and ATP binding cassette transporter A1 in RAW cells. Infect. Immun. 70: 2995-3003. (Pubitemid 34564159)
45. Kaplan, R., X. Gan, J. G. Menke, S. D. Wright, and T. Q. Cai. 2002. Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway. J. Lipid Res. 43: 952-959. (Pubitemid 34602618)
46. Castrillo, A., S. B. Joseph, S. A. Vaidya, M. Haberland, A. M. Fogelman, G. Cheng, and P. Tontonoz. 2003. Crosstalk between LXR and tolllike receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol. Cell. 12: 805-816. (Pubitemid 37352775)
47. Zhang, H. F., H. J. Basra, and U. P. Steinbrecher. 1990. Effects of oxidatively modified LDL on cholesterol esterification in cultured macrophages. J. Lipid Res. 31: 1361-1369.
48. Ohlsson, B. G., M. C. Englund, A. L. Karlsson, E. Knutsen, C. Erixon, H. Skribeck, Y. Liu, G. Bondjers, and O. Wiklund. 1996. Oxidized low density lipoprotein inhibits lipopolysaccharide-induced binding of nuclear factor-κB to DNA and the subsequent expression of tumor necrosis factor-α and interleukin-1β in macrophages. J. Clin. Invest. 98: 78-89.