MR imaging of carotid plaque composition during lipid-lowering therapy: A prospective assessment of effect and time course

JACC: Cardiovascular Imaging

Volumn 4, Issue 9, 2011, Pages 977-986

  Zhao, Xue Qiao ^a   Dong, Li ^a   Hatsukami, Tom ^a   Phan, Binh An ^a   Chu, Baocheng ^a   Moore, Andrew ^a   Lane, Trevor ^a   Neradilek, Moni B ^b   Polissar, Nayak ^b   Monick, Duane ^c   Lee, Colin ^d   Underhill, Hunter ^a   Yuan, Chun ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Mountain Whisper Light Statistics   (United States)

^c Yakima Heart Center   (United States)

^d St Luke's Idaho Cardiology Associates   (United States)

Author keywords

atherosclerosis; carotid artery; lipids; magnetic resonance imaging

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ATORVASTATIN; COLESEVELAM; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY DISEASE; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IMAGE ANALYSIS; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MORPHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT OUTCOME;

APOLIPOPROTEINS B; BIOLOGICAL MARKERS; CALCIUM; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DOUBLE-BLIND METHOD; FEMALE; FIBROSIS; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IDAHO; LIPID METABOLISM; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; NECROSIS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PYRROLES; TIME FACTORS; TREATMENT OUTCOME; WASHINGTON;

EID: 80052805891     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2011.06.013     Document Type: Article

References (35)

1. M.L. Armstrong, and M.B. Megan Lipid depletion in atheromatous coronary arteries in rhesus monkeys after regression diets Circulation Res 30 1972 675 680
2. M.C. Armstrong, and M.B. Megan Arterial fibrous protein in cynomolygous monkeys after atherogenic and regression diets Circulation Res 36 1975 256 261
3. T.B. Clarkson, M.G. Bond, B.C. Bullock, and C.A. Marzetta A study of atherosclerosis regression in Macaca mulatta IV. Changes in coronary arteries from animals with atherosclerosis induced for 19 months and then regressed for 24 or 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl Exp Mol Pathol 34 1981 345 368 (Pubitemid 11087300)
4. D.M. Small, M.G. Bond, D. Waugh, M. Prack, and J.K. Sawyer Physiochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis J Clin Invest 73 1984 1590 1605 (Pubitemid 14084475)
5. M.J. Davies Stability and instability: two faces of coronary atherosclerosis The Paul Dudley White Lecture 1995 Circulation 94 1996 2013 2020
6. A.C. Van der Wal, A.E. Becker, C.M. Van der Loos, and P.K. Das Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 89 1994 36 44 (Pubitemid 24026469)
7. P.R. Moreno, E. Falk, I.F. Palacios, J.B. Newell, V. Fuster, and J.T. Fallon Macrophage infiltration in acute coronary syndromes: implications for plaque rupture Circulation 90 1994 775 778 (Pubitemid 24242744)
8. M.J. Davies, P.D. Richardson, N. Woolf, D.R. Katz, and J. Mann Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophages, and smooth muscle cell content Br Heart J 69 1993 377 381 (Pubitemid 23171108)
9. P. Libby, Y.J. Geng, and M. Aikawa Macrophages and atherosclerotic plaque stability Curr Opin Lipidol 7 1996 330 335 (Pubitemid 26372454)
10. B.G. Brown, and X.-Q. Zhao Lipid-Lowering Therapy C.H. Hennekens, Clinical Trials in Cardiovascular Disease (A Companion to Braunwald's Heart Disease) 1999 WB Saunders Philadelphia, PA 199 216
11. B.G. Brown, X.Q. Zhao, and A. Chait Simvastatin and niacin, antioxidant vitamins, or the combination for prevention of coronary disease N Engl J Med 345 2001 1583 1592 (Pubitemid 33126837)
12. M. Crisby, G. Nordin-Fredriksson, P.K. Shah, J. Yano, J. Zhu, and J. Nilsson Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization Circulation 103 2001 926 933 (Pubitemid 32183796)
13. X.Q. Zhao, Y. Chun, and T.S. Hatsukami Effects of intensive lipid-lowering therapy on carotid atherosclerotic plaque composition in vivo by MRI: a case-control study Arterioscler Thromb Vasc Biol 21 2001 1623 1629 (Pubitemid 34215582)
14. H.R. Underhill, C. Yuan, and X.Q. Zhao Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial Am Heart J 155 2008 584.e1 584.e8
15. M. Shinnar, J.T. Fallon, and S. Wehrli The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization Arterioscler Thromb Vasc Biol 19 1999 2756 2761 (Pubitemid 29536054)
16. C. Yuan, L.M. Mitsumori, and M.S. Ferguson In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques Circulation 104 2001 2051 2056 (Pubitemid 33027045)
17. L.M. Mitsumori, T.S. Hatsukami, M.S. Ferguson, W.S. Kerwin, J. Cai, and C. Yuan In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques J Magn Reson Imaging 17 2003 410 420 (Pubitemid 36396942)
18. V.C. Cappendijk, K.B. Cleutjens, and A.G. Kessels Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience Radiology 234 2005 487 492 (Pubitemid 40139920)
19. T. Saam, J.M. Cai, and Y.Q. Cai Carotid plaque composition differs between ethno-racial groups: an MRI pilot study comparing mainland Chinese and American Caucasian patients Arterioscler Thromb Vasc Biol 25 2005 611 616 (Pubitemid 40315686)
20. S.E. Clarke, R.R. Hammond, J.R. Mitchell, and B.K. Rutt Quantitative assessment of carotid plaque composition using multicontrast MRI and registered histology Magn Reson Med 50 2003 1199 1208 (Pubitemid 37494020)
21. J.M. Cai, T.S. Hatsukami, M.S. Ferguson, R. Small, N.L. Polissar, and C. Yuan Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging Circulation 106 2002 1368 1373 (Pubitemid 35013040)
22. N. Takaya, J. Cai, and M.S. Ferguson Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement J Magn Reson Imaging 24 2006 203 210
23. J.M. Cai, T.S. Hatsukami, and M.S. Ferguson In vivo quantitative measurement of intact fibrous cap and lipid rich necrotic core size in atherosclerotic carotid plaque: a comparison of high resolution contrast enhanced MRI and histology Circulation 112 2005 3437 3444 (Pubitemid 43739559)
24. X.Q. Zhao, B.A. Phan, and B. Chu Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition Study Am Heart J 154 2007 239 246 (Pubitemid 47069140)
25. A.B. Moore, B.A. Phan, C.M. Challender, J. Williamson, S. Marcovina, and X.Q. Zhao Effects of adding extended-release niacin and colesevelam to statin therapy on lipid levels in subjects with atherosclerotic disease J Clin Lipidol 1 2007 620 625 (Pubitemid 350215509)
26. C.E. Hayes, C.M. Mathis, and C. Yuan Surface coil phased arrays for high resolution imaging of the carotid arteries J Magn Reson Imaging 1 1996 109 112 (Pubitemid 126702451)
27. W. Kerwin, D. Xu, and F. Liu Magnetic resonance imaging of carotid atherosclerosis: plaque analysis Top Magn Reson Imaging 18 2007 371 378 (Pubitemid 350145117)
28. R: A Language and Environment for Statistical Computing Version 2.9.0 2009 The R Foundation for Statistical Computing Vienna, Austria
29. H.R. Underhill, C. Yuan, and V.L. Yarnykh Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis AJNR Am J Neuroradiol 31 2009 487 493
30. N. Takaya, C. Yuan, and B. Chu Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRIinitial results Stroke 37 2006 818 823 (Pubitemid 43731915)
31. R. Corti, V. Fuster, and Z.A. Fayad Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging Circulation 106 2002 2884 2887 (Pubitemid 35424736)
32. R. Corti, V. Fuster, and Z.A. Fayad Effects of aggressive versus conventional lipid-lowering therapy by simvastatin on human atherosclerotic lesions: a prospective, randomized, double-blind trial with high-resolution magnetic resonance imaging J Am Coll Cardiol 46 2005 106 112 (Pubitemid 40905137)
33. J.R. Crouse III, J.S. Raichlen, W.A. Riley METEOR Study Group Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR trial JAMA 297 2007 1344 1353 (Pubitemid 46513235)
34. J.J. Kastelein, F. Akdim, E.S. Stroes ENHANCE Investigators Simvastatin with or without ezetimibe in familial hypercholesterolemia N Engl J Med 358 2008 1431 1443 (Pubitemid 351482735)
35. Carotid Plaque Characteristics by MRI in AIM-HIGH http://clinicaltrials. gov/show/NCT01178320 Accessed August 3, 2011