A novel role of OS-9 in the maintenance of intestinal barrier function from hypoxia-induced injury via p38-dependent pathway

International Journal of Biological Sciences

Volumn 11, Issue 6, 2015, Pages 664-671

  Sun, Lihua ^a   Xu, Chao ^a   Chen, Guoqing ^a   Yu, Min ^a   Yang, Songwei ^a   Qiu, Yuan ^a   Peng, Ke ^a   Wang, Wensheng ^a   Xiao, Weidong ^a   Yang, Hua ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Intestinal epithelial barrier; OS 9; P38; Tight junction

Indexed keywords

CLAUDIN 1; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LECTIN; OCCLUDIN; OS9 PROTEIN, HUMAN; TUMOR PROTEIN;

CACO-2 CELL LINE; CELL HYPOXIA; EPITHELIUM CELL; GENE SILENCING; GENETICS; HEK293 CELL LINE; HUMAN; INTESTINE; INTESTINE MUCOSA; METABOLISM; PERMEABILITY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIGHT JUNCTION; UPREGULATION;

CACO-2 CELLS; CELL HYPOXIA; CLAUDIN-1; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTESTINAL MUCOSA; INTESTINES; LECTINS; MAP KINASE SIGNALING SYSTEM; NEOPLASM PROTEINS; OCCLUDIN; PERMEABILITY; PHOSPHORYLATION; TIGHT JUNCTIONS; UP-REGULATION;

EID: 84930668231     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.10783     Document Type: Article

References (38)

1. Assimakopoulos SF, Scopa CD, Charonis A, Spiliopoulou I, Georgiou C, et al. Experimental obstructive jaundice disrupts intestinal mucosal barrier by altering occludin expression: beneficial effect of bombesin and neurotensin. J Am Coll Surg. 2004; 198: 748-757.
2. Schenk M, Mueller C. The mucosal immune system at the gastrointestinal barrier. Best Pract Res Clin Gastroenterol. 2008; 22: 391-409.
3. Colak T, Ozturk C, Polat A, Bagdatoglu O, Kanik A, et al. Effects of trapidil on intestinal mucosal barrier function and bacterial translocation after intestinal ischemia and reperfusion in an experimental rat model. Curr Ther Res Clin Exp. 2003; 64: 355-366.
4. Arda-Pirincci P, Bolkent S. The role of epidermal growth factor in prevention of oxidative injury and apoptosis induced by intestinal ischemia/reperfusion in rats. Acta Histochem. 2014; 116: 167-175.
5. Taylor CT, Colgan SP. Hypoxia and gastrointestinal disease. J Mol Med (Berl). 2007; 85: 1295-1300.
6. Grenz A, Clambey E, Eltzschig HK. Hypoxia signaling during intestinal ischemia and inflammation. Curr Opin Crit Care. 2012; 18: 178-185.
7. Rosenberger P, Khoury J, Kong T, Weissmuller T, Robinson AM, et al. Identification of vasodilator-stimulated phosphoprotein (VASP) as an HIF-regulated tissue permeability factor during hypoxia. FASEB J. 2007; 21: 2613-2621.
8. Feinman R, Deitch EA, Watkins AC, Abungu B, Colorado I, et al. HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2010; 299: G833-843.
9. Kannan KB, Colorado I, Reino D, Palange D, Lu Q, et al. Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2011; 300: G853-861.
10. Liu H, Li M, Wang P, Wang F. Blockade of hypoxia-inducible factor-1α by YC-1 attenuates interferon-γ and tumor necrosis factor-α-induced intestinal epithelial barrier dysfunction. Cytokine. 2011; 56: 581-588.
11. Yang S, Yu M, Sun L, Xiao W, Yang X, et al. Interferon-gamma-induced intestinal epithelial barrier dysfunction by NF-kappaB/HIF-1alpha pathway. J Interferon Cytokine Res. 2014; 34: 195-203.
12. Mahfoudh-Boussaid A, Zaouali MA, Hadj-Ayed K, Miled AH, Saidane-Mosbahi D, et al. Ischemic preconditioning reduces endoplasmic reticulum stress and upregulates hypoxia inducible factor-1alpha in ischemic kidney: the role of nitric oxide. J Biomed Sci. 2012; 19: 7.
13. Kim HJ, Jeong JS, Kim SR, Park SY, Chae HJ, et al. Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-kappaB/HIF-1alpha signaling pathway. Sci Rep. 2013; 3: 1142.
14. Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, et al. OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α. Molecular Cell. 2005; 17: 503-512.
15. Alcock F, Swanton E. Mammalian OS-9 is upregulated in response to endoplasmic reticulum stress and facilitates ubiquitination of misfolded glycoproteins. J Mol Biol. 2009; 385: 1032-1042.
16. Bernasconi R, Pertel T, Luban J, Molinari M. A Dual Task for the Xbp1-responsive OS-9 Variants in the Mammalian Endoplasmic Reticulum: INHIBITING SECRETION OF MISFOLDED PROTEIN CONFORMERS AND ENHANCING THEIR DISPOSAL. Journal of Biological Chemistry. 2008; 283: 16446-16454.
17. Satoh T, Chen Y, Hu D, Hanashima S, Yamamoto K, et al. Structural basis for oligosaccharide recognition of misfolded glycoproteins by OS-9 in ER-associated degradation. Mol Cell. 2010; 40: 905-916.
18. Friedmann E, Salzberg Y, Weinberger A, Shaltiel S, Gerst JE. YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins. J Biol Chem. 2002; 277: 35274-35281.
19. Litovchick L. A Selective Interaction between OS-9 and the Carboxyl-terminal Tail of Meprin beta. Journal of Biological Chemistry. 2002; 277: 34413-34423.
20. Vourvouhaki E, Carvalho C, Aguiar P. Model for Osteosarcoma-9 as a potent factor in cell survival and resistance to apoptosis. Phys Rev E Stat Nonlin Soft Matter Phys. 2007; 76: 01 1926.
21. Flashman E, McDonough MA, Schofield CJ. OS-9Another Piece in the HIF Complex Story. Molecular Cell. 2005; 17: 472-473.
22. Bielinsky A-K, Brockmeier U, Platzek C, Schneider K, Patak P, et al. The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9. PLoS ONE. 2011; 6: e19151.
23. Cerqueira NF, Hussni CA, Yoshida WB. Pathophysiology of mesenteric ischemia/reperfusion: a review. Acta Cir Bras. 2005; 20: 336-343.
24. Li Q, Zhang Q, Wang C, Liu X, Qu L, et al. Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats. J Cell Mol Med. 2009; 13: 4061-4076.
25. Alcock F, Swanton E. Mammalian OS-9 Is Upregulated in Response to Endoplasmic Reticulum Stress and Facilitates Ubiquitination of Misfolded Glycoproteins. Journal of Molecular Biology. 2009; 385: 1032-1042.
26. Jansen BJH, Eleveld-Trancikova D, Sanecka A, van Hout-Kuijer M, Hendriks IAM, et al. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. Molecular Immunology. 2009; 46: 505-515.
27. Wang Y, Fu X, Gaiser S, Kottgen M, Kramer-Zucker A, et al. OS-9 Regulates the Transit and Polyubiquitination of TRPV4 in the Endoplasmic Reticulum. Journal of Biological Chemistry. 2007; 282: 36561-36570.
28. Nakayama T, Yaoi T, Kuwajima G, Yoshie O, Sakata T. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. FEBS Lett. 1999; 453: 77-80.
29. Yu QH, Yang Q. Diversity of tight junctions (TJs) between gastrointestinal epithelial cells and their function in maintaining the mucosal barrier. Cell Biol Int. 2009; 33: 78-82.
30. Schneeberger EE, Lynch RD. The tight junction: a multifunctional complex. Am J Physiol Cell Physiol. 2004; 286: C1213-1228.
31. Colgan SP, Taylor CT. Hypoxia: an alarm signal during intestinal inflammation. Nat Rev Gastroenterol Hepatol. 2010; 7: 281-287.
32. Shah YM, Ito S, Morimura K, Chen C, Yim SH, et al. Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade. Gastroenterology. 2008; 134: 2036-2048, 2048 e2031-2033.
33. Koh MY, Spivak-Kroizman TR, Powis G. HIF-1 regulation: not so easy come, easy go. Trends in Biochemical Sciences. 2008; 33: 526-534.
34. Samak G, Narayanan D, Jaggar JH, Rao R. CaV1.3 channels and intracellular calcium mediate osmotic stress-induced N-terminal c-Jun kinase activation and disruption of tight junctions in Caco-2 CELL MONOLAYERS. J Biol Chem. 2011; 286: 30232-30243.
35. Elamin E, Masclee A, Troost F, Pieters HJ, Keszthelyi D, et al. Ethanol Impairs Intestinal Barrier Function in Humans through Mitogen Activated Protein Kinase Signaling: A Combined In Vivo and In Vitro Approach. PLoS ONE. 2014; 9: e107421.
36. Lee MY, Jung SC, Lee JH, Han HJ. Estradiol-17beta protects against hypoxia-induced hepatocyte injury through ER-mediated upregulation of Bcl-2 as well as ER-independent antioxidant effects. Cell Res. 2008; 18: 491-499.
37. Nguyen DT, Kebache S, Fazel A, Wong HN, Jenna S, et al. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell. 2004; 15: 4248-4260.
38. Darling NJ, Cook SJ. The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Biochim Biophys Acta. 2014; 1843: 2150-2163.