Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

eLife

Volumn 4, Issue MAY, 2015, Pages

  Portugal, Silvia ^a   Tipton, Christopher M ^b,c   Sohn, Haewon ^a   Kone, Younoussou ^d   Wang, Jing ^a   Li, Shanping ^a   Skinner, Jeff ^a   Virtaneva, Kimmo ^a   Sturdevant, Daniel E ^a   Porcella, Stephen F ^a   Doumbo, Ogobara K ^d   Doumbo, Safiatou ^d   Kayentao, Kassoum ^d   Ongoiba, Aissata ^d   Traore, Boubacar ^d   Sanz, Inaki ^b   Pierce, Susan K ^a   Crompton, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d and Technologies of Bamako   (Mali)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CD19 ANTIGEN; CD20 ANTIGEN; CD27 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C GAMMA2; PROTEIN KINASE SYK; DUAL SPECIFICITY PHOSPHATASE; DUAL SPECIFICITY PHOSPHATASE 12; IMMUNOGLOBULIN E; IMMUNOGLOBULIN M; LYMPHOCYTE ANTIGEN RECEPTOR; PARASITE ANTIGEN; PROTOZOON ANTIBODY;

ADULT; ANTIBODY PRODUCTION; ARTICLE; CALCIUM MOBILIZATION ASSAY; CALCIUM TRANSPORT; CELL DIVISION; CELL FRACTIONATION; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CHILD; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; GENE SEQUENCE; HUMAN; HUMAN CELL; MALARIA FALCIPARUM; MALE; MEMORY CELL; NEXT GENERATION SEQUENCING; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN MICROARRAY; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; SOMATIC HYPERMUTATION; ULTRAVIOLET SPECTROPHOTOMETRY; UPREGULATION; ADOLESCENT; B LYMPHOCYTE; BIOSYNTHESIS; CHEMISTRY; GENE EXPRESSION; GENETICS; HOST PARASITE INTERACTION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; MALARIA; MIDDLE AGED; PARASITOLOGY; PATHOGENICITY; PATHOLOGY; PLASMODIUM FALCIPARUM; SIGNAL TRANSDUCTION;

PLASMODIUM FALCIPARUM;

ADOLESCENT; ADULT; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; B-LYMPHOCYTES; CHILD; DUAL-SPECIFICITY PHOSPHATASES; FEMALE; GENE EXPRESSION; HOST-PARASITE INTERACTIONS; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; MALARIA; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION;

EID: 84930667658     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.07218     Document Type: Article

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