Cutting edge: Human FcRL4 and FcRL5 are receptors for IgA and IgG

Journal of Immunology

Volumn 188, Issue 10, 2012, Pages 4741-4745

  Wilson, Timothy J ^a,b   Fuchs, Anja ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; FC RECEPTOR LIKE 4; FC RECEPTOR LIKE 5; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING;

B-LYMPHOCYTES; BINDING SITES, ANTIBODY; CELLS, CULTURED; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ISOTYPES; LYMPHOCYTE ACTIVATION; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECEPTORS, FC; SIGNAL TRANSDUCTION;

EID: 84861130144     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102651     Document Type: Article

References (30)

1. Nimmerjahn, F., and J. V. Ravetch. 2008. Fcg receptors as regulators of immune responses. Nat. Rev. Immunol. 8: 34-47.
2. Raghavan, M., and P. J. Bjorkman. 1996. Fc receptors and their interactions with immunoglobulins. Annu. Rev. Cell Dev. Biol. 12: 181-220. (Pubitemid 26422713)
3. Davis, R. S., Y. H. Wang, H. Kubagawa, and M. D. Cooper. 2001. Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. USA 98: 9772-9777. (Pubitemid 32769379)
4. Hatzivassiliou, G., I. Miller, J. Takizawa, N. Palanisamy, P. H. Rao, S. Iida, S. Tagawa, M. Taniwaki, J. Russo, A. Neri, et al. 2001. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity 14: 277-289. (Pubitemid 32289292)
5. Nakayama, Y., S. M. Weissman, and A. L. Bothwell. 2001. BXMAS1 identifies a cluster of homologous genes differentially expressed in B cells. Biochem. Biophys. Res. Commun. 285: 830-837. (Pubitemid 32924845)
6. Miller, I., G. Hatzivassiliou, G. Cattoretti, C. Mendelsohn, and R. Dalla-Favera. 2002. IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells. Blood 99: 2662-2669. (Pubitemid 34525350)
7. Wilson, T. J., R. M. Presti, I. Tassi, E. T. Overton, M. Cella, and M. Colonna. 2007. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109: 3786-3793. (Pubitemid 46641729)
8. Schreeder, D. M., J. Pan, F. J. Li, E. Vivier, and R. S. Davis. 2008. FCRL6 distinguishes mature cytotoxic lymphocytes and is upregulated in patients with B-cell chronic lymphocytic leukemia. Eur. J. Immunol. 38: 3159-3166.
9. Davis, R. S., H. Li, C. C. Chen, Y. H. Wang, M. D. Cooper, and P. D. Burrows. 2002. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. Int. Immunol. 14: 1075-1083.
10. Facchetti, F., M. Cella, S. Festa, D. H. Fremont, and M. Colonna. 2002. An unusual Fc receptor-related protein expressed in human centroblasts. Proc. Natl. Acad. Sci. USA 99: 3776-3781. (Pubitemid 34252182)
11. Mechetina, L. V., A. M. Najakshin, O. Y. Volkova, S. V. Guselnikov, R. Z. Faizulin, B. Y. Alabyev, N. A. Chikaev, M. S. Vinogradova, and A. V. Taranin. 2002. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. Eur. J. Immunol. 32: 87-96. (Pubitemid 34092825)
12. Chikaev, N. A., E. A. Bykova, A. M. Najakshin, L. V. Mechetina, O. Y. Volkova, M. M. Peklo, A. Y. Shevelev, T. N. Vlasik, A. Roesch, T. Vogt, and A. V. Taranin. 2005. Cloning and characterization of the human FCRL2 gene. Genomics 85: 264-272. (Pubitemid 40164792)
13. Masuda, K., R. S. Davis, T. Maruyama, J. Zhang, T. He, M. D. Cooper, J. O-Wang, and P. D. Burrows. 2005. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Gene 363: 32-40. (Pubitemid 41691890)
14. Polson, A. G., B. Zheng, K. Elkins, W. Chang, C. Du, P. Dowd, L. Yen, C. Tan, J. A. Hongo, H. Koeppen, and A. Ebens. 2006. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Int. Immunol. 18: 1363-1373. (Pubitemid 44446830)
15. Nagata, S., T. Ise, and I. Pastan. 2009. Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J. Immunol. 182: 7518-7526.
16. Ehrhardt, G. R., R. S. Davis, J. T. Hsu, C. M. Leu, A. Ehrhardt, and M. D. Cooper. 2003. The inhibitory potential of Fc receptor homolog 4 on memory B cells. Proc. Natl. Acad. Sci. USA 100: 13489-13494. (Pubitemid 37444769)
17. Falini, B., E. Tiacci, A. Pucciarini, B. Bigerna, J. Kurth, G. Hatzivassiliou, S. Droetto, B. V. Galletti, M. Gambacorta, A. Orazi, et al. 2003. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). Blood 102: 3684-3692. (Pubitemid 37409389)
18. Ehrhardt, G. R., J. T. Hsu, L. Gartland, C. M. Leu, S. Zhang, R. S. Davis, and M. D. Cooper. 2005. Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells. J. Exp. Med. 202: 783-791. (Pubitemid 41345967)
19. Wilson, T. J., and M. Colonna. 2005. A new Fc receptor homolog, FREB2, found in germinal center B cells. Genes Immun. 6: 341-346. (Pubitemid 40903407)
20. Leu, C. M., R. S. Davis, L. A. Gartland, W. D. Fine, and M. D. Cooper. 2005. FcRH1: an activation coreceptor on human B cells. Blood 105: 1121-1126.
21. Haga, C. L., G. R. Ehrhardt, R. J. Boohaker, R. S. Davis, and M. D. Cooper. 2007. Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Proc. Natl. Acad. Sci. USA 104: 9770-9775. (Pubitemid 47175342)
22. Kochi, Y., K. Myouzen, R. Yamada, A. Suzuki, T. Kurosaki, Y. Nakamura, and K. Yamamoto. 2009. FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling. J. Immunol. 183: 5502-5510.
23. Jackson, T. A., C. L. Haga, G. R. Ehrhardt, R. S. Davis, and M. D. Cooper. 2010. FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. J. Immunol. 185: 7405-7412.
24. Schreeder, D. M., J. P. Cannon, J. Wu, R. Li, M. A. Shakhmatov, and R. S. Davis. 2010. Cutting edge: FcR-like 6 is an MHC class II receptor. J. Immunol. 185: 23-27.
25. Wilson, T. J., S. Gilfillan, and M. Colonna. 2010. Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses. J. Immunol. 185: 2960-2967.
26. Santiago, T., S. V. Kulemzin, E. S. Reshetnikova, N. A. Chikaev, O. Y. Volkova, L. V. Mechetina, M. Zhao, R. S. Davis, A. V. Taranin, A. M. Najakshin, et al. 2011. FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA. Int. Immunol. 23: 43-53.
27. Warmerdam, P. A., I. E. van den Herik-Oudijk, P. W. Parren, N. A. Westerdaal, J. G. van de Winkel, and P. J. Capel. 1993. Interaction of a human FcγRIIb1 (CD32) isoform with murine and human IgG subclasses. Int. Immunol. 5: 239-247.
28. Davis, R. S., G. Dennis, Jr., M. R. Odom, A. W. Gibson, R. P. Kimberly, P. D. Burrows, and M. D. Cooper. 2002. Fc receptor homologs: newest members of a remarkably diverse Fc receptor gene family. Immunol. Rev. 190: 123-136. (Pubitemid 36071930)
29. Woof, J. M., and D. R. Burton. 2004. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat. Rev. Immunol. 4: 89-99. (Pubitemid 38209203)
30. Kardava, L., S. Moir, W. Wang, J. Ho, C. M. Buckner, J. G. Posada, M. A. O'Shea, G. Roby, J. Chen, H. W. Sohn, et al. 2011. Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors. J. Clin. Invest. 121: 2614-2624.