Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance

Current Infectious Disease Reports

Volumn 17, Issue 7, 2015, Pages

  Liang, Stephen Y ^a   Kumar, Anand ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HEALTH SCIENCES CENTRE   (Canada)

Author keywords

Antibiotic; Antimicrobial; Combination therapy; Infection; Pharmacokinetics; Sepsis; Septic shock; Survival

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANIDULAFUNGIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA LACTAM ANTIBIOTIC; CASPOFUNGIN; CEFEPIME; CEFMENOXIME; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; CIPROFLOXACIN; COLISTIN; FLUCONAZOLE; GENTAMICIN; LINEZOLID; MEROPENEM; PENICILLIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; POLYPEPTIDE ANTIBIOTIC AGENT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TIGECYCLINE; TIMENTIN; VANCOMYCIN;

ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ANTIMICROBIAL THERAPY; AREA UNDER THE CURVE; BACTEREMIA; BLOODSTREAM INFECTION; CANDIDA; CANDIDIASIS; CAPILLARY PERMEABILITY; COMBINATION CHEMOTHERAPY; COMMUNITY ACQUIRED PNEUMONIA; COMORBIDITY; CONTINUOUS HEMODIALYSIS; CONTINUOUS INFUSION; CONTINUOUS RENAL REPLACEMENT THERAPY; DISEASE COURSE; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG EXCRETION; DRUG MEGADOSE; DRUG POTENCY; DRUG RESPONSE; DRUG TISSUE LEVEL; DRUG USE; EARLY INTERVENTION; EXTRACORPOREAL OXYGENATION; FLUID RESUSCITATION; HOSPITAL INFECTION; HUMAN; HYDROPHILICITY; HYPOALBUMINEMIA; HYPOTENSION; LACTIC ACIDOSIS; LOADING DRUG DOSE; MAINTENANCE THERAPY; MAXIMUM PLASMA CONCENTRATION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MONOTHERAPY; MORBIDITY; MORTALITY; NEPHROTOXICITY; NONHUMAN; NOSOCOMIAL PNEUMONIA; ONSET AGE; OUTCOME ASSESSMENT; PATHOGEN CLEARANCE; PATHOPHYSIOLOGY; PHARMACODYNAMICS; PSEUDOMONAS; RELAPSE; REVIEW; RISK FACTOR; SEPSIS; SEPTIC SHOCK; SINGLE DRUG DOSE; SURVIVAL RATE; SUSTAINED LOW EFFICIENCY DIALYSIS; TREATMENT FAILURE; VANCOMYCIN RESISTANT ENTEROCOCCUS;

EID: 84930661662     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-015-0493-6     Document Type: Review

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