Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells

Redox Biology

Volumn 5, Issue , 2015, Pages 153-162

  Banerjee, Kacoli ^a   Mandal, Mahitosh ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

Apigenin; Oxidative stress; Pro oxidation; Reactive oxygen species; Senescence

Indexed keywords

APIGENIN; CYCLIN D1; CYCLIN E; FREE RADICAL; PROTEIN P16; PROTEIN P21; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; SUPEROXIDE; ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLINE;

AGING; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CHEMOPROPHYLAXIS; COLORECTAL CANCER CELL LINE; HCT 15 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM EXPOSURE; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION; CELL AGING; COLORECTAL TUMOR; DRUG EFFECTS; HT-29 CELL LINE; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APIGENIN; APOPTOSIS; CELL AGING; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; HT29 CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; SUPEROXIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84930630637     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.04.009     Document Type: Article

References (29)

1. Pandey K.B., Rizvi S.I. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cellular Longevity 2009, 2(5):270-278. http://www.ncbi.nlm.nih.gov/pubmed/20716914, 10.4161/oxim.2.5.9498.
2. Rice-Evans C. Flavonoids and isoflavones: absorption, metabolism, and bioactivity. Free Radical Biology and Medicine 2004, 36(7):827-828. http://www.ncbi.nlm.nih.gov/pubmed/15019967, 10.1016/j.freeradbiomed.2003.12.012.
3. Tsuchiya H. Structure-dependent membrane interaction of flavonoids associated with their bioactivity. Food Chemistry 2010, 120(4):1089-1096. 10.1016/j.foodchem.2009.11.057.
4. Ferrari N., Tosetti F., De Flora S., Donatelli F., Sogno I., Noonan D.M., Albini A. Diet-derived phytochemicals: from cancer chemoprevention to cardio-oncological prevention. Current Drug Targets 2011, 12(13):1909-1924. http://www.ncbi.nlm.nih.gov/pubmed/21158708, 10.2174/138945011798184227.
5. Patel D., Shukla S., Gupta S. Apigenin and cancer chemoprevention: progress, potential and promise. International Journal of Oncology 2007, 30(1):233-245. http://www.ncbi.nlm.nih.gov/pubmed/17143534, 10.3892/ijo.30.1.233.
6. Ruela-de-Sousa R.R., Fuhler G.M., Blom N., Ferreira C.V., Aoyama H., Peppelenbosch M.P. Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. Cell Death and Disease 2010, 1:e19. http://www.ncbi.nlm.nih.gov/pubmed/21364620, 10.1038/cddis.2009.18.
7. Shukla S., Gupta S. Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radical Biology and Medicine 2008, 44(10):1833-1845. http://www.ncbi.nlm.nih.gov/pubmed/18342637, 10.1016/j.freeradbiomed.2008.02.007.
8. Lugli E., Troiano L., Ferraresi R., Roat E., Prada N., Nasi M., Pinti M., Cooper E.L., Cossarizza A. Characterization of cells with different mitochondrial membrane potential during apoptosis. Cytometry Part A 2005, 68(1):28-35. http://www.ncbi.nlm.nih.gov/pubmed/16184612, 10.1002/cyto.a.20188.
9. Galati G., Sabzevari O., Wilson J.X., O'Brien P.J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 2002, 177(1):91-104. http://www.ncbi.nlm.nih.gov/pubmed/12126798, 10.1016/S0300-483X(02)00198-1.
10. Banerjee S., Sen K., Pal T.K., Guha S.K. Poly(styrene-co-maleic acid)-based pH-sensitive liposomes mediate cytosolic delivery of drugs for enhanced cancer chemotherapy. International Journal of Pharmaceutics 2012, 436(1-2):786-797. http://www.ncbi.nlm.nih.gov/pubmed/22884831, 10.1016/j.ijpharm.2012.07.059.
11. Eruslanov E., Kusmartsev S. Identification of ROS using oxidized DCFDA and flow-cytometry. Methods in Molecular Biology 2010, 594:57-72. http://www.ncbi.nlm.nih.gov/pubmed/20072909, 10.1007/978-1-60761-411-1_4.
12. Chae S.Y., Lee M., Kim S.W., Bae Y.H. Protection of insulin secreting cells from nitric oxide induced cellular damage by crosslinked hemoglobin. Biomaterials 2004, 25(5):843-850. http://www.ncbi.nlm.nih.gov/pubmed/14609673, 10.1016/S0142-9612(03)00605-7.
13. Ryu S.-W., Woo J.H., Kim Y.-H., Lee Y.-S., Park J.W., Bae Y.-S. Downregulation of protein kinase CKII is associated with cellular senescence. FEBS Letters 2006, 580(3):988-994. http://www.ncbi.nlm.nih.gov/pubmed/16442104, 10.1016/j.febslet.2006.01.028.
14. Shin G.-C., Kim C., Lee J.-M., Cho W.-S., Lee S.-G., Jeong M., Cho J., Lee K. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes. Chemico-Biological Interactions 2009, 182(1):29-36. http://www.ncbi.nlm.nih.gov/pubmed/19647729, 10.1016/j.cbi.2009.07.016.
15. Mukhopadhyay P., Rajesh M., Haskó G., Hawkins B.J., Madesh M., Pacher P. Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nature Protocols 2007, 2(9):2295-2301. http://www.ncbi.nlm.nih.gov/pubmed/17853886, 10.1038/nprot.2007.327.
16. Cadenas E., Davies K.J.A. Mitochondrial free radical generation, oxidative stress, and aging. Free Radical Biology and Medicine 2000, 29(3-4):222-230. http://www.ncbi.nlm.nih.gov/pubmed/11035250, 10.1016/S0891-5849(00)00317-8.
17. Kyrylkova K., Kyryachenko S., Leid M., Kioussi C. Detection of apoptosis by TUNEL assay. Methods in Molecular Biology 2012, 887:41-47. http://www.ncbi.nlm.nih.gov/pubmed/22566045, 10.1007/978-1-61779-860-3_5.
18. Czabotar P.E., Lessene G., Strasser A., Adams J.M. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nature Reviews Molecular Cell Biology 2014, 15(1):49-63. http://www.ncbi.nlm.nih.gov/pubmed/24355989, 10.1038/nrm3722.
19. Dasari A., Bartholomew J.N., Volonte D., Galbiati F. Oxidative stress induces premature senescence by stimulating Caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-Rich promoter elements. Cancer Research 2006, 66(22):10805-10814. http://www.ncbi.nlm.nih.gov/pubmed/17108117, 10.1158/0008-5472.CAN-06-1236.
20. Debacq-Chainiaux F., Erusalimsky J.D., Campisi J., Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo. Nature Protocols 2009, 4(12):1798-1806. http://www.ncbi.nlm.nih.gov/pubmed/20010931, 10.1038/nprot.2009.191.
21. Volonte D., Zhang K., Lisanti M.P., Galbiati F. Expression of Caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Molecular Biology of the Cell 2002, 13(7):2502-2517. http://www.ncbi.nlm.nih.gov/pubmed/12134086, 10.1091/mbc.01-11-0529.
22. Hu B. Liver yin deficiency tonifying herbal extract induces apoptosis and cell senescence in Bel-7402 human hepatocarcinoma cells. Experimental and Therapeutic Medicine 2011, 10.3892/etm.2011.364.
23. Narasimha A.M., Kaulich M., Shapiro G.S., Choi Y.J., Sicinski P., Dowdy S.F. Cyclin D activates the Rb tumor suppressor by mono-phosphorylation. eLife 2014, 3. http://www.ncbi.nlm.nih.gov/pubmed/24876129, 10.7554/eLife.02872.
24. Hwang H.C., Clurman B.E. Cyclin E in normal and neoplastic cell cycles. Oncogene 2005, 24(17):2776-2786. http://www.ncbi.nlm.nih.gov/pubmed/15838514, 10.1038/sj.onc.1208613.
25. Geng Y., Yu Q., Sicinska E., Das M., Bronson R.T., Sicinski P. Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proceedings of the National Academy of Sciences 2001, 98(1):194-199. http://www.ncbi.nlm.nih.gov/pubmed/11134518, 10.1073/pnas.011522998.
26. Ravizza R., Gariboldi M.B., Passarelli L., Monti E. Role of the p53/p21 system in the response of human colon carcinoma cells to doxorubicin. BMC Cancer 2004, 4:92. http://www.ncbi.nlm.nih.gov/pubmed/15601469, 10.1186/1471-2407-4-92.
27. Harman D. Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 1956, 11(3):298-300. http://www.ncbi.nlm.nih.gov/pubmed/13332224, 10.1093/geronj/11.3.298.
28. Sies H. Oxidative stress: from basic research to clinical application. The American Journal of Medicine 1991, 91(3C):31S-38S. http://www.ncbi.nlm.nih.gov/pubmed/1928209, 10.1016/0002-9343(91)90281-2.
29. Drew B., Leeuwenburgh C. Aging and the role of reactive nitrogen species. Annals of the New York Academy of Sciences 2002, 959:66-81. http://www.ncbi.nlm.nih.gov/pubmed/11976187, 10.1111/j.1749-6632.2002.tb02084.x.