Crystallization kinetics and molecular mobility of an amorphous active pharmaceutical ingredient: A case study with Biclotymol

International Journal of Pharmaceutics

Volumn 490, Issue 1-2, 2015, Pages 248-257

  Schammé, Benjamin ^a,b   Couvrat, Nicolas ^a   Malpeli, Pascal ^c   Delbreilh, Laurent ^b   Dupray, Valérie ^a   Dargent, Éric ^b   Coquerel, Gérard ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ ET INSA DE ROUEN   (France)

^c Pharmasynthese (Inabata Group)   (France)

Author keywords

Amorphous; Biclotymol; Crystallization; Molecular mobility; Nucleation; Stability

Indexed keywords

ANTIINFECTIVE AGENT; BICLOTYMOL; GLASS; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; 2,2-METHYLENEBIS(4-CHLORO-3-METHYL-ISOPROPYLPHENOL); DRUG; POWDER;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STORAGE; DRUG STRUCTURE; GLASS TRANSITION TEMPERATURE; HOT STAGE MICROSCOPY; MICROSCOPY; MOLECULAR DYNAMICS; MOLECULAR MOBILITY; PHYSICAL PARAMETERS; PHYSICAL PHENOMENA; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMODYNAMICS; X RAY POWDER DIFFRACTION; CHEMISTRY; COLD; KINETICS; POWDER; PROCEDURES; TRANSITION TEMPERATURE; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; COLD TEMPERATURE; CRYSTALLIZATION; GLASS; KINETICS; MOLECULAR DYNAMICS SIMULATION; PHARMACEUTICAL PREPARATIONS; PHENOLS; POWDERS; THERMODYNAMICS; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 84930626844     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.05.036     Document Type: Article

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