Stability of amorphous pharmaceutical solids: Crystal growth mechanisms and effect of polymer additives

AAPS Journal

Volumn 14, Issue 3, 2012, Pages 380-388

  Sun, Ye ^b   Zhu, Lei ^c   Wu, Tian ^d   Cai, Ting ^a   Gunn, Erica M ^a   Yu, Lian ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Massachusetts Institute of Technology   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d AMGEN INC   (United States)

Author keywords

amorphous solid; crystal growth; crystallization; crystallization inhibitor; glass; glass transition; polymer additive; surface molecular mobility

Indexed keywords

CARBAMAZEPINE; DRUG ADDITIVE; GLASS; GRISEOFULVIN; NANOCOATING; NIFEDIPINE; POLYMER; POVIDONE;

BIOTRANSFORMATION; CONCENTRATION (PARAMETERS); CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFUSION; DRUG COATING; DRUG STABILITY; HYDROGEN BOND; MATERIAL COATING; MOLECULAR INTERACTION; MOLECULAR STABILITY; MOLECULAR WEIGHT; REVIEW; SOLID STATE; SURFACE PROPERTY; TEMPERATURE SENSITIVITY; THERMOSTABILITY;

CRYSTALLIZATION; DRUG STABILITY; KINETICS; PHARMACEUTICAL PREPARATIONS; POLYMERS;

EID: 84862768376     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9345-6     Document Type: Review

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