Estimating the In Vivo Killing Efficacy of Cytotoxic T Lymphocytes across Different Peptide-MHC Complex Densities

PLoS Computational Biology

Volumn 11, Issue 5, 2015, Pages

  Garcia, Victor ^a   Richter, Kirsten ^a   Graw, Frederik ^b   Oxenius, Annette ^a   Regoes, Roland R ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; CYTOLOGY; EPITOPES; ESTIMATION; MAMMALS; T-CELLS; VIRUSES;

CYTOTOXIC T LYMPHOCYTES; EXPERIMENTAL METHODS; HOST CELLS; IMMUNODOMINANT EPITOPES; IN-VIVO; INFECTED CELLS; INTRACELLULAR PATHOGENS; ORDERS OF MAGNITUDE; TARGET CELLS; VIRUS INFECTION;

PEPTIDES;

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS PEPTIDE; VIRUS PROTEIN; PEPTIDE; VIRAL PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL KILLING; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY ASSAY; EFFECTOR CELL; FEMALE; IN VIVO STUDY; INNATE IMMUNITY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL MODEL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PREDICTION; VIRUS LOAD; ADOPTIVE TRANSFER; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; CYTOTOXICITY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; VIROLOGY;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, VIRAL; COMPUTATIONAL BIOLOGY; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; HOST-PATHOGEN INTERACTIONS; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MODELS, IMMUNOLOGICAL; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC; VIRAL PROTEINS;

EID: 84930607819     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004178     Document Type: Article

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