Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Cancer Cell

Volumn 27, Issue 6, 2015, Pages 864-876

  Cole, Alicia ^a   Wang, Zezhou ^a   Coyaud, Etienne ^a   Voisin, Veronique ^b   Gronda, Marcela ^a   Jitkova, Yulia ^a   Mattson, Rachel ^a   Hurren, Rose ^a   Babovic, Sonja ^c   Maclean, Neil ^a   Restall, Ian ^a   Wang, Xiaoming ^a   Jeyaraju, Danny V ^a   Sukhai, Mahadeo A ^a   Prabha, Swayam ^a   Bashir, Shaheena ^b   Ramakrishnan, Ashwin ^a   Leung, Elisa ^b   Qia, Yi Hua ^d   Zhang, Nianxian ^d,h   Combes, Kevin R ^d   Ketela, Troy ^b   Lin, Fengshu ^a   Houry, Walid A ^b   Aman, Ahmed ^e   Al awar, Rima ^e,f   Zheng, Wei ^g   Wienholds, Erno ^a,b   Xu, Chang Jiang ^b   Dick, John ^a,b   Wang, Jean C Y ^a,b   Moffat, Jason ^b   Minden, Mark D ^a,b   Eaves, Connie J ^c   Bader, Gary D ^b   Hao, Zhenyue ^a   Kornblau, Steven M ^d   Raught, Brian ^a   Schimmer, Aaron D ^a,b   more..

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

^h THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 2 32 01; ANTILEUKEMIC AGENT; ENDOPEPTIDASE CLP; MITOCHONDRIAL PROTEIN; PROTEIN; RESPIRATORY CHAIN PROTEIN; SERINE PROTEINASE INHIBITOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; CLPP PROTEIN, HUMAN; ENZYME INHIBITOR; SMALL INTERFERING RNA;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; FEMALE; GENETIC SCREENING; HEMATOPOIESIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION; RESPIRATORY CHAIN; RNA INTERFERENCE; TUMOR VOLUME; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; KNOCKOUT MOUSE; LEUKEMIA, MYELOID, ACUTE; METABOLISM; SCID MOUSE; XENOGRAFT;

MUS;

ANIMALS; ENDOPEPTIDASE CLP; ENZYME INHIBITORS; HETEROGRAFTS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MICE, KNOCKOUT; MICE, SCID; RNA, SMALL INTERFERING;

EID: 84930586847     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2015.05.004     Document Type: Article

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