메뉴 건너뛰기




Volumn 22, Issue 4, 2015, Pages 359-373

BRAF gene: From human cancers to developmental syndromes

Author keywords

BRAF gene; Cancers; Developmental syndromes; RAS RAF overactivation

Indexed keywords


EID: 84930579253     PISSN: 1319562X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sjbs.2014.10.002     Document Type: Review
Times cited : (66)

References (131)
  • 1
    • 79959834625 scopus 로고    scopus 로고
    • Reflex BRAF testing in thyroid fine-needle aspiration biopsy with equivocal and positive interpretation: a prospective study
    • Adeniran A.J., Theoharis C., Hui P., Prasad M.L., Hammers L., Carling T., Udelsman R., Chhieng D.C. Reflex BRAF testing in thyroid fine-needle aspiration biopsy with equivocal and positive interpretation: a prospective study. Thyroid 2011, 21:717-723.
    • (2011) Thyroid , vol.21 , pp. 717-723
    • Adeniran, A.J.1    Theoharis, C.2    Hui, P.3    Prasad, M.L.4    Hammers, L.5    Carling, T.6    Udelsman, R.7    Chhieng, D.C.8
  • 2
    • 84899648145 scopus 로고
    • Noonan syndrome
    • University of Washington, Seattle, WA, R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, K. Stephens (Eds.)
    • Allanson J.E., Roberts A.E. Noonan syndrome. GeneReviews 1993, University of Washington, Seattle, WA. R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, K. Stephens (Eds.).
    • (1993) GeneReviews
    • Allanson, J.E.1    Roberts, A.E.2
  • 4
    • 84872924215 scopus 로고    scopus 로고
    • Ras/MAPK syndromes and childhood hemato-oncological diseases
    • Aoki Y., Matsubara Y. Ras/MAPK syndromes and childhood hemato-oncological diseases. Int. J. Hematol. 2013, 97:30-36.
    • (2013) Int. J. Hematol. , vol.97 , pp. 30-36
    • Aoki, Y.1    Matsubara, Y.2
  • 8
    • 27744531210 scopus 로고    scopus 로고
    • The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis
    • Bauer A.J., Stratakis C.A. The lentiginoses: cutaneous markers of systemic disease and a window to new aspects of tumourigenesis. J. Med. Genet. 2005, 42:801-810.
    • (2005) J. Med. Genet. , vol.42 , pp. 801-810
    • Bauer, A.J.1    Stratakis, C.A.2
  • 12
    • 34250639863 scopus 로고    scopus 로고
    • Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR
    • Bettstetter M., Dechant S., Ruemmele P., Grabowski M., Keller G., Holinski-Feder E., Hartmann A., Hofstaedter F., Dietmaier W. Distinction of hereditary nonpolyposis colorectal cancer and sporadic microsatellite-unstable colorectal cancer through quantification of MLH1 methylation by real-time PCR. Clin. Cancer Res. 2007, 13:3221-3228.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3221-3228
    • Bettstetter, M.1    Dechant, S.2    Ruemmele, P.3    Grabowski, M.4    Keller, G.5    Holinski-Feder, E.6    Hartmann, A.7    Hofstaedter, F.8    Dietmaier, W.9
  • 17
    • 84873715417 scopus 로고    scopus 로고
    • Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR
    • Bosmuller H., Fischer A., Pham D.L., Fehm T., Capper D., von Deimling A., Bonzheim I., Staebler A., Fend F. Detection of the BRAF V600E mutation in serous ovarian tumors: a comparative analysis of immunohistochemistry with a mutation-specific monoclonal antibody and allele-specific PCR. Hum. Pathol. 2013, 44:329-335.
    • (2013) Hum. Pathol. , vol.44 , pp. 329-335
    • Bosmuller, H.1    Fischer, A.2    Pham, D.L.3    Fehm, T.4    Capper, D.5    von Deimling, A.6    Bonzheim, I.7    Staebler, A.8    Fend, F.9
  • 19
    • 84886290631 scopus 로고    scopus 로고
    • The impact of genomic changes on treatment of lung cancer
    • Cardarella S., Johnson B.E. The impact of genomic changes on treatment of lung cancer. Am. J. Respir. Crit. Care Med. 2013, 188:770-775.
    • (2013) Am. J. Respir. Crit. Care Med. , vol.188 , pp. 770-775
    • Cardarella, S.1    Johnson, B.E.2
  • 26
    • 84888021467 scopus 로고    scopus 로고
    • BRAF mutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis
    • Clancy C., Burke J.P., Kalady M.F., Coffey J.C. BRAF mutation is associated with distinct clinicopathological characteristics in colorectal cancer: a systematic review and meta-analysis. Colorectal Dis. 2013, 15:e711-e718.
    • (2013) Colorectal Dis. , vol.15 , pp. e711-e718
    • Clancy, C.1    Burke, J.P.2    Kalady, M.F.3    Coffey, J.C.4
  • 29
    • 1642535480 scopus 로고    scopus 로고
    • BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
    • Deng G., Bell I., Crawley S., Gum J., Terdiman J.P., Allen B.A., Truta B., Sleisenger M.H., Kim Y.S. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin. Cancer Res. 2004, 10:191-195.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 191-195
    • Deng, G.1    Bell, I.2    Crawley, S.3    Gum, J.4    Terdiman, J.P.5    Allen, B.A.6    Truta, B.7    Sleisenger, M.H.8    Kim, Y.S.9
  • 33
    • 84883717868 scopus 로고    scopus 로고
    • Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer
    • Feng C., Gao Y., Wang C., Yu X., Zhang W., Guan H., Shan Z., Teng W. Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer. J. Clin. Endocrinol. Metab. 2013, 98:E1524-E1533.
    • (2013) J. Clin. Endocrinol. Metab. , vol.98 , pp. E1524-E1533
    • Feng, C.1    Gao, Y.2    Wang, C.3    Yu, X.4    Zhang, W.5    Guan, H.6    Shan, Z.7    Teng, W.8
  • 35
    • 0026092357 scopus 로고
    • The cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome: are they the same?
    • Fryer A.E., Holt P.J., Hughes H.E. The cardio-facio-cutaneous (CFC) syndrome and Noonan syndrome: are they the same?. Am. J. Med. Genet. 1991, 38:548-551.
    • (1991) Am. J. Med. Genet. , vol.38 , pp. 548-551
    • Fryer, A.E.1    Holt, P.J.2    Hughes, H.E.3
  • 39
    • 84960340450 scopus 로고
    • LEOPARD syndrome
    • University of Washington, Seattle, WA, R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, K. Stephens (Eds.)
    • Gelb B.D., Tartaglia M. LEOPARD syndrome. GeneReviews 1993, University of Washington, Seattle, WA. R.A. Pagon, M.P. Adam, T.D. Bird, C.R. Dolan, C.T. Fong, K. Stephens (Eds.).
    • (1993) GeneReviews
    • Gelb, B.D.1    Tartaglia, M.2
  • 40
    • 79952225388 scopus 로고    scopus 로고
    • RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it
    • Gelb B.D., Tartaglia M. RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it. J. Clin. Investig. 2011, 121:844-847.
    • (2011) J. Clin. Investig. , vol.121 , pp. 844-847
    • Gelb, B.D.1    Tartaglia, M.2
  • 41
    • 84897399512 scopus 로고    scopus 로고
    • The life and times of low-grade serous carcinoma of the ovary, American Society of Clinical Oncology educational book/ASCO
    • Gershenson D.M. The life and times of low-grade serous carcinoma of the ovary, American Society of Clinical Oncology educational book/ASCO. Am. Soc. Clin. Oncol.: Meeting 2013, 2013:195-199.
    • (2013) Am. Soc. Clin. Oncol.: Meeting , vol.2013 , pp. 195-199
    • Gershenson, D.M.1
  • 43
    • 84874403175 scopus 로고    scopus 로고
    • RAS/MAPK signal transduction pathway and its role in the pathogenesis of Noonan syndrome
    • Gos M., Leszkiewicz M., Abramowicz A. RAS/MAPK signal transduction pathway and its role in the pathogenesis of Noonan syndrome. Postepy Biochem. 2012, 58:255-264.
    • (2012) Postepy Biochem. , vol.58 , pp. 255-264
    • Gos, M.1    Leszkiewicz, M.2    Abramowicz, A.3
  • 46
    • 73849142941 scopus 로고    scopus 로고
    • Malignant diseases in Noonan syndrome and related disorders
    • Hasle H. Malignant diseases in Noonan syndrome and related disorders. Horm. Res. 2009, 72(Suppl. 2):8-14.
    • (2009) Horm. Res. , vol.72 , pp. 8-14
    • Hasle, H.1
  • 47
    • 84878634489 scopus 로고    scopus 로고
    • Prognostic significance of C-reactive protein polymorphism and KRAS/BRAF in synchronous liver metastasis from colorectal cancer
    • Huang C.J., Teng H.W., Chien C.C., Lin J.K., Yang S.H. Prognostic significance of C-reactive protein polymorphism and KRAS/BRAF in synchronous liver metastasis from colorectal cancer. PLoS ONE 2013, 8:e65117.
    • (2013) PLoS ONE , vol.8 , pp. e65117
    • Huang, C.J.1    Teng, H.W.2    Chien, C.C.3    Lin, J.K.4    Yang, S.H.5
  • 49
    • 84890515668 scopus 로고    scopus 로고
    • Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings
    • Hussain M.R., Nasir J., Al-Aama J.Y. Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. J. Cell. Biochem. 2014, 115:313-327.
    • (2014) J. Cell. Biochem. , vol.115 , pp. 313-327
    • Hussain, M.R.1    Nasir, J.2    Al-Aama, J.Y.3
  • 51
    • 66149090765 scopus 로고    scopus 로고
    • Molecular pathogenesis of cutaneous melanocytic neoplasms
    • Ibrahim N., Haluska F.G. Molecular pathogenesis of cutaneous melanocytic neoplasms. Annu. Rev. Pathol. 2009, 4:551-579.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 551-579
    • Ibrahim, N.1    Haluska, F.G.2
  • 54
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas
    • Jones D.T., Kocialkowski S., Liu L., Pearson D.M., Backlund L.M., Ichimura K., Collins V.P. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res. 2008, 68:8673-8677.
    • (2008) Cancer Res. , vol.68 , pp. 8673-8677
    • Jones, D.T.1    Kocialkowski, S.2    Liu, L.3    Pearson, D.M.4    Backlund, L.M.5    Ichimura, K.6    Collins, V.P.7
  • 55
    • 0029869251 scopus 로고    scopus 로고
    • LEOPARD syndrome (cardiocutaneous lentiginosis syndrome)
    • Jozwiak S., Schwartz R.A., Janniger C.K. LEOPARD syndrome (cardiocutaneous lentiginosis syndrome). Cutis 1996, 57:208-214.
    • (1996) Cutis , vol.57 , pp. 208-214
    • Jozwiak, S.1    Schwartz, R.A.2    Janniger, C.K.3
  • 56
    • 0029027050 scopus 로고
    • Vaginal rhabdomyosarcoma in a patient with Noonan syndrome
    • Khan S., McDowell H., Upadhyaya M., Fryer A. Vaginal rhabdomyosarcoma in a patient with Noonan syndrome. J. Med. Genet. 1995, 32:743-745.
    • (1995) J. Med. Genet. , vol.32 , pp. 743-745
    • Khan, S.1    McDowell, H.2    Upadhyaya, M.3    Fryer, A.4
  • 57
    • 84882714061 scopus 로고    scopus 로고
    • A case of multifocal papillary thyroid carcinoma consisting of one encapsulated follicular variant with BRAF K601E mutation and three conventional types with BRAF V600E mutation
    • Kim W.Y., Ko Y.S., Hwang T.S., Han H.S., Lim S.D., Kim W.S., Oh S.Y. A case of multifocal papillary thyroid carcinoma consisting of one encapsulated follicular variant with BRAF K601E mutation and three conventional types with BRAF V600E mutation. Korean J Pathol. 2013, 47:293-298.
    • (2013) Korean J Pathol. , vol.47 , pp. 293-298
    • Kim, W.Y.1    Ko, Y.S.2    Hwang, T.S.3    Han, H.S.4    Lim, S.D.5    Kim, W.S.6    Oh, S.Y.7
  • 59
    • 84872920575 scopus 로고    scopus 로고
    • Ovarian cancer: making its own rules-again
    • Kohn E.C., Hurteau J. Ovarian cancer: making its own rules-again. Cancer 2013, 119:474-476.
    • (2013) Cancer , vol.119 , pp. 474-476
    • Kohn, E.C.1    Hurteau, J.2
  • 61
    • 68949116127 scopus 로고    scopus 로고
    • Novel BRAF mutation in a patient with LEOPARD syndrome and normal intelligence
    • Koudova M., Seemanova E., Zenker M. Novel BRAF mutation in a patient with LEOPARD syndrome and normal intelligence. Eur. J. Med. Genet. 2009, 52:337-340.
    • (2009) Eur. J. Med. Genet. , vol.52 , pp. 337-340
    • Koudova, M.1    Seemanova, E.2    Zenker, M.3
  • 64
    • 84880174415 scopus 로고    scopus 로고
    • Papillary thyroid carcinoma recurring as squamous cell carcinoma 10 years after total thyroidectomy: lessons from rapidly progressive papillary thyroid carcinoma
    • Lee J.I., Chung Y.J., Lee S.Y. Papillary thyroid carcinoma recurring as squamous cell carcinoma 10 years after total thyroidectomy: lessons from rapidly progressive papillary thyroid carcinoma. Intern. Med. (Tokyo, Japan) 2013, 52:1593-1597.
    • (2013) Intern. Med. (Tokyo, Japan) , vol.52 , pp. 1593-1597
    • Lee, J.I.1    Chung, Y.J.2    Lee, S.Y.3
  • 65
    • 84878581633 scopus 로고    scopus 로고
    • KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells
    • Lewandowska M.A., Jozwicki W., Zurawski B. KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells. Mol. Diag. Ther. 2013, 17:193-203.
    • (2013) Mol. Diag. Ther. , vol.17 , pp. 193-203
    • Lewandowska, M.A.1    Jozwicki, W.2    Zurawski, B.3
  • 66
    • 32044455746 scopus 로고    scopus 로고
    • BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    • Li W.Q., Kawakami K., Ruszkiewicz A., Bennett G., Moore J., Iacopetta B. BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol. Cancer 2006, 5:2.
    • (2006) Mol. Cancer , vol.5 , pp. 2
    • Li, W.Q.1    Kawakami, K.2    Ruszkiewicz, A.3    Bennett, G.4    Moore, J.5    Iacopetta, B.6
  • 78
    • 79956304968 scopus 로고    scopus 로고
    • Molecular diagnostics of thyroid tumors
    • Nikiforov Y.E. Molecular diagnostics of thyroid tumors. Arch. Pathol. Lab. Med. 2011, 135:569-577.
    • (2011) Arch. Pathol. Lab. Med. , vol.135 , pp. 569-577
    • Nikiforov, Y.E.1
  • 83
    • 84889073458 scopus 로고    scopus 로고
    • Two cases of clear cell sarcoma with different clinical and genetic features: cutaneous type with BRAF mutation and subcutaneous type with KIT mutation
    • Park B.M., Jin S.A., Choi Y.D., Shin S.H., Jung S.T., Lee J.B., Lee S.C., Yun S.J. Two cases of clear cell sarcoma with different clinical and genetic features: cutaneous type with BRAF mutation and subcutaneous type with KIT mutation. Br. J. Dermatol. 2013.
    • (2013) Br. J. Dermatol.
    • Park, B.M.1    Jin, S.A.2    Choi, Y.D.3    Shin, S.H.4    Jung, S.T.5    Lee, J.B.6    Lee, S.C.7    Yun, S.J.8
  • 84
    • 0034762203 scopus 로고    scopus 로고
    • The Raf/MEK/ERK pathway: new concepts of activation
    • Peyssonnaux C., Eychene A. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell 2001, 93:53-62.
    • (2001) Biol. Cell , vol.93 , pp. 53-62
    • Peyssonnaux, C.1    Eychene, A.2
  • 87
    • 84897030769 scopus 로고    scopus 로고
    • BRAF mutation assessment in papillary thyroid cancer: are we ready to use it in clinical practice
    • Puxeddu E., Filetti S. BRAF mutation assessment in papillary thyroid cancer: are we ready to use it in clinical practice. Endocrine 2013, 45:341-343.
    • (2013) Endocrine , vol.45 , pp. 341-343
    • Puxeddu, E.1    Filetti, S.2
  • 94
    • 0022454854 scopus 로고
    • New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement-the CFC syndrome
    • Reynolds J.F., Neri G., Herrmann J.P., Blumberg B., Coldwell J.G., Miles P.V., Opitz J.M. New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement-the CFC syndrome. Am. J. Med. Genet. 1986, 25:413-427.
    • (1986) Am. J. Med. Genet. , vol.25 , pp. 413-427
    • Reynolds, J.F.1    Neri, G.2    Herrmann, J.P.3    Blumberg, B.4    Coldwell, J.G.5    Miles, P.V.6    Opitz, J.M.7
  • 98
    • 33745404717 scopus 로고    scopus 로고
    • Utility of BRAF V600E mutation detection in cytologically indeterminate thyroid nodules
    • Rowe L.R., Bentz B.G., Bentz J.S. Utility of BRAF V600E mutation detection in cytologically indeterminate thyroid nodules. CytoJournal 2006, 3:10.
    • (2006) CytoJournal , vol.3 , pp. 10
    • Rowe, L.R.1    Bentz, B.G.2    Bentz, J.S.3
  • 103
    • 77950360748 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in prostate carcinomas of Chinese patients
    • Shen Y., Lu Y., Yin X., Zhu G., Zhu J. KRAS and BRAF mutations in prostate carcinomas of Chinese patients. Cancer Genet. Cytogenet. 2010, 198:35-39.
    • (2010) Cancer Genet. Cytogenet. , vol.198 , pp. 35-39
    • Shen, Y.1    Lu, Y.2    Yin, X.3    Zhu, G.4    Zhu, J.5
  • 104
  • 105
    • 79952429680 scopus 로고    scopus 로고
    • Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome
    • Siegel D.H., McKenzie J., Frieden I.J., Rauen K.A. Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome. Br. J. Dermatol. 2011, 164:521-529.
    • (2011) Br. J. Dermatol. , vol.164 , pp. 521-529
    • Siegel, D.H.1    McKenzie, J.2    Frieden, I.J.3    Rauen, K.A.4
  • 109
    • 84880322946 scopus 로고    scopus 로고
    • Case records of the Massachusetts General Hospital. Case 21-2013. A 68-year-old man with metastatic melanoma
    • Sullivan R.J., Lawrence D.P., Wargo J.A., Oh K.S., Gonzalez R.G., Piris A. Case records of the Massachusetts General Hospital. Case 21-2013. A 68-year-old man with metastatic melanoma. N. Engl. J. Med. 2013, 369:173-183.
    • (2013) N. Engl. J. Med. , vol.369 , pp. 173-183
    • Sullivan, R.J.1    Lawrence, D.P.2    Wargo, J.A.3    Oh, K.S.4    Gonzalez, R.G.5    Piris, A.6
  • 114
    • 58149395502 scopus 로고    scopus 로고
    • Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway
    • Tidyman W.E., Rauen K.A. Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev. Mol. Med. 2008, 10:e37.
    • (2008) Expert Rev. Mol. Med. , vol.10 , pp. e37
    • Tidyman, W.E.1    Rauen, K.A.2
  • 115
    • 68649121646 scopus 로고    scopus 로고
    • The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
    • Tidyman W.E., Rauen K.A. The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr. Opin. Genet. Dev. 2009, 19:230-236.
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 230-236
    • Tidyman, W.E.1    Rauen, K.A.2
  • 117
    • 84876956920 scopus 로고    scopus 로고
    • A combined 3D-QSAR and molecular docking strategy to understand the binding mechanism of (V600E)B-RAF inhibitors
    • Ul-Haq Z., Mahmood U., Reza S. A combined 3D-QSAR and molecular docking strategy to understand the binding mechanism of (V600E)B-RAF inhibitors. Mol. Diversity 2012, 16:771-785.
    • (2012) Mol. Diversity , vol.16 , pp. 771-785
    • Ul-Haq, Z.1    Mahmood, U.2    Reza, S.3
  • 119
    • 69349088990 scopus 로고    scopus 로고
    • Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems
    • Vang R., Shih Ie.M., Kurman R.J. Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat. Pathol. 2009, 16:267-282.
    • (2009) Adv Anat. Pathol. , vol.16 , pp. 267-282
    • Vang, R.1    Shih, I.2    Kurman, R.J.3
  • 120
    • 24344505403 scopus 로고    scopus 로고
    • High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes
    • Vasko V., Hu S., Wu G., Xing J.C., Larin A., Savchenko V., Trink B., Xing M. High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes. J. Clin. Endocrinol. Metab. 2005, 90:5265-5269.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 5265-5269
    • Vasko, V.1    Hu, S.2    Wu, G.3    Xing, J.C.4    Larin, A.5    Savchenko, V.6    Trink, B.7    Xing, M.8
  • 122
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7
    • Wajapeyee N., Serra R.W., Zhu X., Mahalingam M., Green M.R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 2008, 132:363-374.
    • (2008) Cell , vol.132 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 126
    • 79952233533 scopus 로고    scopus 로고
    • MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf 1(L613V) mutation
    • Wu X., Simpson J., Hong J.H., Kim K.H., Thavarajah N.K., Backx P.H., Neel B.G., Araki T. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf 1(L613V) mutation. J. Clin. Investig. 2011, 121:1009-1025.
    • (2011) J. Clin. Investig. , vol.121 , pp. 1009-1025
    • Wu, X.1    Simpson, J.2    Hong, J.H.3    Kim, K.H.4    Thavarajah, N.K.5    Backx, P.H.6    Neel, B.G.7    Araki, T.8
  • 128
    • 37349131738 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications
    • Xing M. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr. Rev. 2007, 28:742-762.
    • (2007) Endocr. Rev. , vol.28 , pp. 742-762
    • Xing, M.1
  • 130
    • 84878901220 scopus 로고    scopus 로고
    • The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis
    • Yuan Z.X., Wang X.Y., Qin Q.Y., Chen D.F., Zhong Q.H., Wang L., Wang J.P. The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis. PLoS ONE 2013, 8:e65995.
    • (2013) PLoS ONE , vol.8 , pp. e65995
    • Yuan, Z.X.1    Wang, X.Y.2    Qin, Q.Y.3    Chen, D.F.4    Zhong, Q.H.5    Wang, L.6    Wang, J.P.7
  • 131
    • 84857980063 scopus 로고    scopus 로고
    • BRAF mutation testing in clinical practice
    • Ziai J., Hui P. BRAF mutation testing in clinical practice. Expert Rev. Mol. Diagn. 2012, 12:127-138.
    • (2012) Expert Rev. Mol. Diagn. , vol.12 , pp. 127-138
    • Ziai, J.1    Hui, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.