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Volumn 34, Issue 10, 2009, Pages 803-809

Pharmacological manipulation of calcium-sensing receptor: Prospect as anabolic therapy for postmenopausal osteoporosis

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYLPYRROLIDINE DERIVATIVE; 2 CHLORO 6 [3 [1,1 DIMETHYL 2 (2 NAPHTHYL)ETHYLAMINO] 2 HYDROXYPROPOXY]BENZONITRILE; 4 ARYL 1H QUINAZOLIN 2 ONE DERIVATIVE; ANABOLIC AGENT; CALCIUM SENSING RECEPTOR; CINACALCET; ESTRADIOL; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; N1 ARYLSULFONYL N2 [1 (1 NAPHTHYL)ETHYL] 1 ,2 DIAMINOCYCLOHEXANE DER; PARATHYROID HORMONE; PARATHYROID HORMONE[1-34]; RECOMBINANT PARATHYROID HORMONE; RONACALERET; STRONTIUM RANELATE; UNCLASSIFIED DRUG;

EID: 84930539071     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2009.034.10.1415096     Document Type: Review
Times cited : (4)

References (53)
  • 1
    • 0025922923 scopus 로고
    • Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers
    • Brown, E.M. Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol Rev 1991, 71(2): 371-411.
    • (1991) Physiol Rev , vol.71 , Issue.2 , pp. 371-411
    • Brown, E.M.1
  • 2
    • 0035138842 scopus 로고    scopus 로고
    • Extracellular calcium sensing and extracellular calcium signaling
    • Brown, E.M., MacLeod, R.J. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001, 81(1): 239-7.
    • (2001) Physiol Rev , vol.81 , Issue.1 , pp. 239-247
    • Brown, E.M.1    MacLeod, R.J.2
  • 3
    • 0024600149 scopus 로고    scopus 로고
    • Hawkins, D., Enyedi, P., Brown, E. The effects of high extracellular Ca2+ and Mg2+ concentrations on the levels of inositol 1,3,4,5-tetrakisphosphate in bovine parathyroid cells. Endocrinology 1989, 124(2): 838-44.
    • Hawkins, D., Enyedi, P., Brown, E. The effects of high extracellular Ca2+ and Mg2+ concentrations on the levels of inositol 1,3,4,5-tetrakisphosphate in bovine parathyroid cells. Endocrinology 1989, 124(2): 838-44.
  • 4
    • 0027765508 scopus 로고
    • Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    • Brown, E.M., Gamba, G., Riccardi, D. et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993, 366(6455): 575-80.
    • (1993) Nature , vol.366 , Issue.6455 , pp. 575-580
    • Brown, E.M.1    Gamba, G.2    Riccardi, D.3
  • 5
    • 33846429183 scopus 로고    scopus 로고
    • Clinical lessons from the calcium-sensing receptor
    • Brown, E.M. Clinical lessons from the calcium-sensing receptor. Nat Clin Pract Endocrinol Metab 2007, 3(2): 122-33.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , Issue.2 , pp. 122-133
    • Brown, E.M.1
  • 6
    • 0038125588 scopus 로고    scopus 로고
    • Extracellular calcium sensing and signalling
    • Hofer, A.M, Brown, E.M. Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 2003, 4(7): 530-8.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.7 , pp. 530-538
    • Hofer, A.M.1    Brown, E.M.2
  • 7
    • 33748966446 scopus 로고    scopus 로고
    • Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing
    • Chattopadhyay, N., Brown, E.M. Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab 2006, 89(3): 189-202.
    • (2006) Mol Genet Metab , vol.89 , Issue.3 , pp. 189-202
    • Chattopadhyay, N.1    Brown, E.M.2
  • 9
    • 4344603756 scopus 로고    scopus 로고
    • Allosteric modulation of G protein-coupled receptors: Perspectives and recent developments
    • Soudijn, W., Van Wijngaarden, I., Ijzerman, A.P. Allosteric modulation of G protein-coupled receptors: Perspectives and recent developments. Drug Discov Today 2004, 9(17): 752-8.
    • (2004) Drug Discov Today , vol.9 , Issue.17 , pp. 752-758
    • Soudijn, W.1    Van Wijngaarden, I.2    Ijzerman, A.P.3
  • 10
    • 0034806606 scopus 로고    scopus 로고
    • Calcilytic compounds: Potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone
    • Nemeth, E.F., Delmar, E.G., Heaton, W.L. et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther 2001, 299(1): 323-31.
    • (2001) J Pharmacol Exp Ther , vol.299 , Issue.1 , pp. 323-331
    • Nemeth, E.F.1    Delmar, E.G.2    Heaton, W.L.3
  • 12
    • 76749132453 scopus 로고    scopus 로고
    • Anabolics in osteoporosis: The emerging therapeutic tool
    • Epud ahead of print
    • Trivedi, R., Mithal, A., Chattopadhyay, N. Anabolics in osteoporosis: The emerging therapeutic tool. Curr Mol Med 2009, Epud ahead of print.
    • (2009) Curr Mol Med
    • Trivedi, R.1    Mithal, A.2    Chattopadhyay, N.3
  • 13
    • 0036605816 scopus 로고    scopus 로고
    • Developments in parathyroid hormone and related peptides as bone-formation agents
    • Fox, J. Developments in parathyroid hormone and related peptides as bone-formation agents. Curr Opin Pharmacol 2002, 2(3): 338-44.
    • (2002) Curr Opin Pharmacol , vol.2 , Issue.3 , pp. 338-344
    • Fox, J.1
  • 14
    • 67649687522 scopus 로고    scopus 로고
    • PTH-analogs: Comparable or different?
    • Verhaar, H.J., Lems, W.F. PTH-analogs: Comparable or different? Arch Gerontol Geriatr 2009 ,49(2): e130-2.
    • (2009) Arch Gerontol Geriatr , vol.49 , Issue.2
    • Verhaar, H.J.1    Lems, W.F.2
  • 15
    • 0027514232 scopus 로고
    • The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats
    • Kimmel, D.B., Bozzato, R.P., Kronis, K.A., Coble, T., Sindrey, D., Kwong, P., Recker, R.R. The effect of recombinant human (1-84) or synthetic human (1-34) parathyroid hormone on the skeleton of adult osteopenic ovariectomized rats. Endocrinology 1993, 132(4): 1577-84.
    • (1993) Endocrinology , vol.132 , Issue.4 , pp. 1577-1584
    • Kimmel, D.B.1    Bozzato, R.P.2    Kronis, K.A.3    Coble, T.4    Sindrey, D.5    Kwong, P.6    Recker, R.R.7
  • 16
    • 0023461898 scopus 로고
    • Bone and plasma calcium homeostasis
    • Parfitt, A.M. Bone and plasma calcium homeostasis. Bone 1987, 8(Suppl. 1): S1-8.
    • (1987) Bone , vol.8 , Issue.SUPPL. 1
    • Parfitt, A.M.1
  • 17
    • 0024342682 scopus 로고
    • Plasma calcium control at quiescent bone surfaces: A new approach to the homeostatic function of bone lining cells
    • Parfitt, A.M. Plasma calcium control at quiescent bone surfaces: A new approach to the homeostatic function of bone lining cells. Bone 1989, 10(2): 87-8.
    • (1989) Bone , vol.10 , Issue.2 , pp. 87-88
    • Parfitt, A.M.1
  • 18
    • 0032847386 scopus 로고    scopus 로고
    • Physiology and pathophysiology of bone remodeling
    • Raisz, L.G. Physiology and pathophysiology of bone remodeling. Clin Chem 1999, 45(8, Pt. 2): 1353-8.
    • (1999) Clin Chem , vol.45 , Issue.8 and PART. 2 , pp. 1353-1358
    • Raisz, L.G.1
  • 19
    • 1842636568 scopus 로고    scopus 로고
    • Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones
    • Dvorak, M.M., Siddiqua, A., Ward, D.T., Carter, D.H., Dallas, S.L., Nemeth, E.F., Riccardi, D. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci U S A 2004, 101(14): 5140-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.14 , pp. 5140-5145
    • Dvorak, M.M.1    Siddiqua, A.2    Ward, D.T.3    Carter, D.H.4    Dallas, S.L.5    Nemeth, E.F.6    Riccardi, D.7
  • 20
    • 1442326037 scopus 로고    scopus 로고
    • Ca2+ as an extracellular signal in bone
    • Dvorak, M.M., Riccardi, D. Ca2+ as an extracellular signal in bone. Cell Calcium 2004, 35(3): 249-55.
    • (2004) Cell Calcium , vol.35 , Issue.3 , pp. 249-255
    • Dvorak, M.M.1    Riccardi, D.2
  • 22
    • 0346363825 scopus 로고    scopus 로고
    • In vitro studies with the calcimimetic, cinacalcet HCI, on normal human adult osteoblastic and osteoclastic cells
    • Shalhoub, V., Grisanti, M., Padagas, J. et al. In vitro studies with the calcimimetic, cinacalcet HCI, on normal human adult osteoblastic and osteoclastic cells. Crit Rev Eukaryot Gene Expr 2003, 13(2-4): 89-106.
    • (2003) Crit Rev Eukaryot Gene Expr , vol.13 , Issue.2-4 , pp. 89-106
    • Shalhoub, V.1    Grisanti, M.2    Padagas, J.3
  • 23
    • 33947311829 scopus 로고    scopus 로고
    • Pharmacological characterization of mouse CPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations
    • Christiansen, B., Hansen, K.B., Wellendorph, P., Brauner-Osborne, H. Pharmacological characterization of mouse CPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. Br J Pharmacol 2007, 150(6): 798-807.
    • (2007) Br J Pharmacol , vol.150 , Issue.6 , pp. 798-807
    • Christiansen, B.1    Hansen, K.B.2    Wellendorph, P.3    Brauner-Osborne, H.4
  • 24
    • 39049088260 scopus 로고    scopus 로고
    • Recent updates on the calcium-sensing receptor as a drug target
    • Trivedi, R., Mithal, A., Chattopadhyay, N. Recent updates on the calcium-sensing receptor as a drug target. Curr Med Chem 2008, 15(2): 178-86.
    • (2008) Curr Med Chem , vol.15 , Issue.2 , pp. 178-186
    • Trivedi, R.1    Mithal, A.2    Chattopadhyay, N.3
  • 25
    • 0032540096 scopus 로고    scopus 로고
    • Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells
    • Kameda, T., Mano, H., Yamada, Y. et al. Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells. Biochem Biophys Res Commun 1998, 245(2): 419-22.
    • (1998) Biochem Biophys Res Commun , vol.245 , Issue.2 , pp. 419-422
    • Kameda, T.1    Mano, H.2    Yamada, Y.3
  • 27
    • 0016822122 scopus 로고
    • The relative spatial distributions of CFUs and CFUc in the normal mouse femur
    • Lord, B.I., Testa, N.G., Hendry, J.H. The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood 1975, 46(1): 65-72.
    • (1975) Blood , vol.46 , Issue.1 , pp. 65-72
    • Lord, B.I.1    Testa, N.G.2    Hendry, J.H.3
  • 28
    • 0017834345 scopus 로고
    • Endosteal marrow: A rich source of hematopoietic stem cells
    • Gong, J.K. Endosteal marrow: A rich source of hematopoietic stem cells. Science 1978, 199(4336): 1443-5.
    • (1978) Science , vol.199 , Issue.4336 , pp. 1443-1445
    • Gong, J.K.1
  • 29
    • 0030781163 scopus 로고    scopus 로고
    • Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells
    • House, M.G., Kohlmeier, L., Chattopadhyay, N. et al. Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J Bone Miner Res 1997, 12(12): 1959-70.
    • (1997) J Bone Miner Res , vol.12 , Issue.12 , pp. 1959-1970
    • House, M.G.1    Kohlmeier, L.2    Chattopadhyay, N.3
  • 31
    • 20044361853 scopus 로고    scopus 로고
    • Strontium ranelate: A novel mode of action optimizing bone formation and resorption
    • Marie, P.J. Strontium ranelate: A novel mode of action optimizing bone formation and resorption. Osteoporos Int 2005, 16(Suppl. 1): S7-10.
    • (2005) Osteoporos Int , vol.16 , Issue.SUPPL. 1
    • Marie, P.J.1
  • 32
    • 34250870142 scopus 로고    scopus 로고
    • The calcium-sensing receptor (CaR) is involved in strontium ranelote-induced osteoblast proliferation
    • Chattopadhyay, N., Quinn, S.J., Kifor, O., Ye, C., Brown, E.M. The calcium-sensing receptor (CaR) is involved in strontium ranelote-induced osteoblast proliferation. Biochem Pharmacol 2007, 74(3): 438-47.
    • (2007) Biochem Pharmacol , vol.74 , Issue.3 , pp. 438-447
    • Chattopadhyay, N.1    Quinn, S.J.2    Kifor, O.3    Ye, C.4    Brown, E.M.5
  • 33
    • 33845649734 scopus 로고    scopus 로고
    • The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis
    • Mentaverri, R., Yano, S:, Chattopadhyay, N. et al. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J 2006, 20(14): 2562-4.
    • (2006) FASEB J , vol.20 , Issue.14 , pp. 2562-2564
    • Mentaverri, R.1    Yano, S.2    Chattopadhyay, N.3
  • 34
    • 0034937704 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology
    • Hofbauer, L.C., Heufelder, A.E. Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology. J Mol Med 2001, 79(5-6): 243-53.
    • (2001) J Mol Med , vol.79 , Issue.5-6 , pp. 243-253
    • Hofbauer, L.C.1    Heufelder, A.E.2
  • 35
    • 37349123534 scopus 로고    scopus 로고
    • Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
    • Bonnelye, E., Chabadel, A., Saltel, F., Jurdic, P. Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 2008, 42(1): 129-38.
    • (2008) Bone , vol.42 , Issue.1 , pp. 129-138
    • Bonnelye, E.1    Chabadel, A.2    Saltel, F.3    Jurdic, P.4
  • 36
    • 84930541357 scopus 로고    scopus 로고
    • The morphology and lattice structure of bone crystal after strontium treatment in goats
    • Epub ahead of print
    • Li, Z., Lu, W.W., Deng, L. et al. The morphology and lattice structure of bone crystal after strontium treatment in goats. J Bone Miner Metab 2009, Epub ahead of print.
    • (2009) J Bone Miner Metab
    • Li, Z.1    Lu, W.W.2    Deng, L.3
  • 37
    • 0036668566 scopus 로고    scopus 로고
    • The search for calcium receptor antagonists (calcilytics)
    • Nemeth, E.F. The search for calcium receptor antagonists (calcilytics). J Mol Endocrinol 2002, 29(1): 15-21.
    • (2002) J Mol Endocrinol , vol.29 , Issue.1 , pp. 15-21
    • Nemeth, E.F.1
  • 38
    • 65749117230 scopus 로고    scopus 로고
    • The discovery of novel calcium sensing receptor negative allosteric modulators
    • Balan, G., Bauman, J., Bhattacharya, S. et al. The discovery of novel calcium sensing receptor negative allosteric modulators. Bioorg Med Chem Lett 2009, 19(12): 3328-32.
    • (2009) Bioorg Med Chem Lett , vol.19 , Issue.12 , pp. 3328-3332
    • Balan, G.1    Bauman, J.2    Bhattacharya, S.3
  • 39
    • 67649573533 scopus 로고    scopus 로고
    • Ronacaleret, a novel calcium-sensing receptor antagonist, demonstrates potential as an oral bone-forming therapy in healthy postmenopausal women
    • Abst 1174
    • Fitzpatrick L., Brennan, E., Kumar, S. et al. Ronacaleret, a novel calcium-sensing receptor antagonist, demonstrates potential as an oral bone-forming therapy in healthy postmenopausal women. J Bone Miner Res 2008, 23(Suppl. S): Abst 1174.
    • (2008) J Bone Miner Res , vol.23 , Issue.SUPPL. S
    • Fitzpatrick, L.1    Brennan, E.2    Kumar, S.3
  • 40
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget, S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev 1989, 8(2): 98-101.
    • (1989) Cancer Metastasis Rev , vol.8 , Issue.2 , pp. 98-101
    • Paget, S.1
  • 41
    • 33646386892 scopus 로고    scopus 로고
    • Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy
    • Chattopadhyay, N. Effects of calcium-sensing receptor on the secretion of parathyroid hormone-related peptide and its impact on humoral hypercalcemia of malignancy. Am J Physiol Endocrinol Metab 2006, 290(5): E761-70.
    • (2006) Am J Physiol Endocrinol Metab , vol.290 , Issue.5
    • Chattopadhyay, N.1
  • 42
    • 0025751703 scopus 로고
    • Parathyroid hormone-related protein: Elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer
    • Grill, V., Ho, P., Body, J.J. et al. Parathyroid hormone-related protein: Elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 1991, 73(6): 1309-15.
    • (1991) J Clin Endocrinol Metab , vol.73 , Issue.6 , pp. 1309-1315
    • Grill, V.1    Ho, P.2    Body, J.J.3
  • 43
    • 0025779371 scopus 로고
    • Calcium-stimulated parathyroid hormone-like protein secretion: Potentiation through a protein kinase-C pathway
    • Brandt, D.W., Pandol, S.J., Deftos, L.J. Calcium-stimulated parathyroid hormone-like protein secretion: Potentiation through a protein kinase-C pathway. Endocrinology 1991, 128(6): 2999-3004.
    • (1991) Endocrinology , vol.128 , Issue.6 , pp. 2999-3004
    • Brandt, D.W.1    Pandol, S.J.2    Deftos, L.J.3
  • 44
    • 0028858407 scopus 로고
    • Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D
    • Naveh-Many, T., Rahamimov, R., Livni, N., Silver, J. Parathyroid cell proliferation in normal and chronic renal failure rats. The effects of calcium, phosphate, and vitamin D. J Clin Invest 1995, 96(4): 1786-93.
    • (1995) J Clin Invest , vol.96 , Issue.4 , pp. 1786-1793
    • Naveh-Many, T.1    Rahamimov, R.2    Livni, N.3    Silver, J.4
  • 45
    • 0026323752 scopus 로고    scopus 로고
    • Wernerson, A., Widholm, S.M., Svensson, O., Reinholt, F.P. Parathyroid cell number and size in hypocalcemic young rats. APMID 1991, 99(12): 1096-102.
    • Wernerson, A., Widholm, S.M., Svensson, O., Reinholt, F.P. Parathyroid cell number and size in hypocalcemic young rats. APMID 1991, 99(12): 1096-102.
  • 46
    • 4544349506 scopus 로고    scopus 로고
    • N′-Arylsulfonyl-N2-(1-(1-naphthyl)ethyl)-1,2- diaminocyclohexans: A new class of catalytic agents acting on the calcium-sensing receptor
    • Kessler, A., Faure, H., Roussanne, M.C., Ferry, S., Ruat, M., Dauban, P., Dodd, R.H. N′-Arylsulfonyl-N2-(1-(1-naphthyl)ethyl)-1,2- diaminocyclohexans: A new class of catalytic agents acting on the calcium-sensing receptor. ChemBioChem 2004, 5(8): 1131-6.
    • (2004) ChemBioChem , vol.5 , Issue.8 , pp. 1131-1136
    • Kessler, A.1    Faure, H.2    Roussanne, M.C.3    Ferry, S.4    Ruat, M.5    Dauban, P.6    Dodd, R.H.7
  • 47
    • 2442548717 scopus 로고    scopus 로고
    • Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain
    • Petrel, C., Kessler, A., Dauban, P., Dodd, R.H., Rognan, D., Ruat, M. Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J Biol Chem 2004, 279(18): 18990-7.
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18990-18997
    • Petrel, C.1    Kessler, A.2    Dauban, P.3    Dodd, R.H.4    Rognan, D.5    Ruat, M.6
  • 48
    • 20144382860 scopus 로고    scopus 로고
    • A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo
    • Arey, B.J., Seethala, R., Ma, Z. et al. A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo. Endocrinology 2005, 146(4): 2015-22.
    • (2005) Endocrinology , vol.146 , Issue.4 , pp. 2015-2022
    • Arey, B.J.1    Seethala, R.2    Ma, Z.3
  • 50
    • 84930542363 scopus 로고    scopus 로고
    • Altmann, E, Beerli, R, Gerspacher, M, Renaud, J, Weiler, S, Widler, L, Novartis AG; Novartis Pharma GmbH, Aryl-quinazoline/aryl-2aminophenyl methanone derivatives. WO 2004056365
    • Altmann, E., Beerli, R., Gerspacher, M., Renaud, J., Weiler, S., Widler, L. (Novartis AG; Novartis Pharma GmbH). Aryl-quinazoline/aryl-2aminophenyl methanone derivatives. WO 2004056365.
  • 51
    • 20144387408 scopus 로고    scopus 로고
    • Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists
    • Yang, W., Wang, Y., Roberge, J.Y. et al. Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists. Bioorg Med Chem Lett 2005, 15(4): 1225-8.
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.4 , pp. 1225-1228
    • Yang, W.1    Wang, Y.2    Roberge, J.Y.3
  • 52
    • 64349117373 scopus 로고    scopus 로고
    • Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists
    • Yang, W., Ruan, Z., Wang, Y. et al. Discovery and structure-activity relationships of trisubstituted pyrimidines/pyridines as novel calcium-sensing receptor antagonists. J Med Chem 2009, 52(4): 1204-8.
    • (2009) J Med Chem , vol.52 , Issue.4 , pp. 1204-1208
    • Yang, W.1    Ruan, Z.2    Wang, Y.3
  • 53
    • 14644388720 scopus 로고    scopus 로고
    • 3H-Quinazolin-4-ones as a new catalytic template for the potential treatment of osteoporosis
    • Shcherbakova, I., Balandrin, M.F., Fox, J., Ghatak, A., Heaton, W.L., Conklin, R.L. 3H-Quinazolin-4-ones as a new catalytic template for the potential treatment of osteoporosis. Bioorg Med Chem Lett 2005, 15(6): 1557-60.
    • (2005) Bioorg Med Chem Lett , vol.15 , Issue.6 , pp. 1557-1560
    • Shcherbakova, I.1    Balandrin, M.F.2    Fox, J.3    Ghatak, A.4    Heaton, W.L.5    Conklin, R.L.6


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