Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder

Journal of Psychopharmacology

Volumn 27, Issue 7, 2013, Pages 651-654

  Niciu, Mark J ^a,b   Grunschel, Beth D G ^a   Corlett, Philip R ^a   Pittenger, Christopher ^a,c   Bloch, Michael H ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

depression; Ketamine; OCD; SAE; suicidality

Indexed keywords

ACETYLCYSTEINE; ALPRAZOLAM; FLUVOXAMINE; KETAMINE; NEUROLEPTIC AGENT; RILUZOLE; SEROTONIN UPTAKE INHIBITOR;

ADULT; ANXIETY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMORBIDITY; DEPERSONALIZATION; DISEASE EXACERBATION; DRUG EFFECT; DRUG INFUSION; DRUG SAFETY; DYSPHORIA; FEMALE; HUMAN; LIMB DISEASE; LIMB PARESTHESIA; MAJOR DEPRESSION; NAUSEA; OBSESSIVE COMPULSIVE DISORDER; OPEN STUDY; ORAL PARESTHESIA; PARESTHESIA; PERSONALITY DISORDER; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; SIDE EFFECT; SUICIDAL IDEATION; SYMPTOM; TRICHOTILLOMANIA;

DEPRESSION; KETAMINE; OCD; SAE; SUICIDALITY;

ADULT; ANXIETY; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; KETAMINE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; SUICIDAL IDEATION;

EID: 84879407498     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881113486718     Document Type: Article

References (21)

1. Blagrove M, Morgan CJ, Curran HV, et al. The incidence of unpleasant dreams after sub-anaesthetic ketamine. Psychopharmacology (Berl). 2009 ; 203: 109-120
2. Bloch MH, Wasylink S, Landeros-Weisenberger A, et al. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry. 2012 ; 72: 964-970
3. Clements JA, Nimmo WS, Grant IS. Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci. 1982 ; 71: 539-542
4. Corlett PR, Krystal JH, Taylor JR, et al. Why do delusions persist?. Front Hum Neurosci. 2009 ; 3: 12
5. Corlett PR, Taylor JR, Wang XJ, et al. Toward a neurobiology of delusions. Prog Neurobiol. 2010 ; 92: 345-369
6. Das-Munshi J, Goldberg D, Bebbington PE, et al. Public health significance of mixed anxiety and depression: beyond current classification. Br J Psychiatry. 2008 ; 192: 171-177
7. Denk MC, Rewerts C, Holsboer F, et al. Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation. Am J Psychiatry. 2011 ; 168: 751-752
8. DiazGranados N, Ibrahim LA, Brutsche NE, et al. Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder. J Clin Psychiatry. 2010 ; 71: 1605-1611
9. Domino EF. Taming the ketamine tiger. 1965. Anesthesiology. 2010 ; 113: 678-684
10. Krystal JH, Petrakis IL, Limoncelli D, et al. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Neuropsychopharmacology. 2003 ; 28: 2020-2028
11. Li N, Lee B, Liu RJ, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010 ; 329: 959-964
12. Li N, Liu RJ, Dwyer JM, et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry. 2011 ; 69: 754-761
13. Perry EB, Cramer JA, Cho HS, et al. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology (Berl). 2007 ; 192: 253-260
14. Petrakis IL, Limoncelli D, Gueorguieva R, et al. Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am J Psychiatry. 2004 ; 161: 1776-1782
15. Pfeiffer PN, Ganoczy D, Ilgen M, et al. Comorbid anxiety as a suicide risk factor among depressed veterans. Depress Anxiety. 2009 ; 26: 752-757
16. Price RB, Nock MK, Charney DS, et al. Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry. 2009 ; 66: 522-526
17. Sluzenski J, Newcombe NS, Kovacs SL. Binding, relational memory, and recall of naturalistic events: a developmental perspective. J Exp Psychol Learn Mem Cogn. 2006 ; 32: 89-100
18. Wolff K, Winstock AR. Ketamine: From medicine to misuse. CNS Drugs. 2006 ; 20: 199-218
19. Zarate CA, Brutsche N, Laje G, et al. Relationship of ketamine's plasma metabolites with response, diagnosis, and side effects in major depression. Biol Psychiatry. 2012 ; 72: 331-338
20. Zeng MC, Niciu MJ, Luckenbaugh DA, et al. Acute stress symptoms do not worsen in posttraumatic stress disorder and abuse with a single subanesthetic dose of ketamine. Biol Psychiatry. 2012 ;:
21. Zisook S, Trivedi MH, Warden D, et al. Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: An examination of citalopram in the STAR*D study. J Affect Disord. 2009 ; 117: 63-73