Persistent activation of STAT3 by PIM2-driven positive feedback loop for epithelial-mesenchymal transition in breast cancer

Cancer Science

Volumn 106, Issue 6, 2015, Pages 718-725

  Uddin, Nizam ^a   Kim, Rae Kwon ^a   Yoo, Ki Chun ^a   Kim, Young Heon ^a   Cui, Yan Hong ^a   Kim, In Gyu ^b   Suh, Yongjoon ^a   Lee, Su Jae ^a  

^a Hanyang University   (South Korea)

^b Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Cytokines; Epithelial mesenchymal transition; PIM2; Positive feedback loop; STAT3

Indexed keywords

INTERLEUKIN 1ALPHA; INTERLEUKIN 8; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; SMALL INTERFERING RNA; STAT3 PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR ZEB1; VIMENTIN; HOMEODOMAIN PROTEIN; IL8 PROTEIN, HUMAN; ONCOPROTEIN; PIM2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; STAT3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; ZEB1 PROTEIN, HUMAN;

ARTICLE; BREAST CANCER; BREAST CANCER CELL LINE; CARCINOGENICITY; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR INVASION; BREAST TUMOR; CELL MOTION; FEMALE; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-8; NEOPLASM INVASIVENESS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

EID: 84930417741     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12668     Document Type: Article

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