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Volumn 26, Issue 11, 2015, Pages 1971-1984

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CYCLIN DEPENDENT KINASE 5; PROTEIN KINASE B; ROSCOVITINE; SERINE; TRANSCRIPTION FACTOR; AR PROTEIN, HUMAN; CDK5 PROTEIN, HUMAN;

EID: 84930389493     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-12-1634     Document Type: Article
Times cited : (34)

References (47)
  • 1
    • 5144228549 scopus 로고    scopus 로고
    • High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence
    • Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W (2004). High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clin Cancer Res 10, 6572-6578.
    • (2004) Clin Cancer Res , vol.10 , pp. 6572-6578
    • Ayala, G.1    Thompson, T.2    Yang, G.3    Frolov, A.4    Li, R.5    Scardino, P.6    Ohori, M.7    Wheeler, T.8    Harper, W.9
  • 4
    • 84863245741 scopus 로고    scopus 로고
    • Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation
    • Chen S, Gulla S, Cai C, Balk SP (2012b). Androgen receptor serine 81 phosphorylation mediates chromatin binding and transcriptional activation. J Biol Chem 287, 8571-8583.
    • (2012) J Biol Chem , vol.287 , pp. 8571-8583
    • Chen, S.1    Gulla, S.2    Cai, C.3    Balk, S.P.4
  • 5
    • 33750452673 scopus 로고    scopus 로고
    • Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1
    • Chen S, Xu Y, Yuan X, Bubley GJ, Balk SP (2006). Androgen receptor phosphorylation and stabilization in prostate cancer by cyclin-dependent kinase 1. Proc Natl Acad Sci USA 103, 15969-15974.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15969-15974
    • Chen, S.1    Xu, Y.2    Yuan, X.3    Bubley, G.J.4    Balk, S.P.5
  • 6
    • 84857781607 scopus 로고    scopus 로고
    • Cdk5: A multifaceted kinase in neurodegenerative diseases
    • Cheung ZH, Ip NY (2012). Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol 22, 169-175.
    • (2012) Trends Cell Biol , vol.22 , pp. 169-175
    • Cheung, Z.H.1    Ip, N.Y.2
  • 8
    • 79953198258 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways
    • Daval M, Gurlo T, Costes S, Huang C-J, Butler PC (2011). Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways. Diabetes 60, 1186-1197.
    • (2011) Diabetes , vol.60 , pp. 1186-1197
    • Daval, M.1    Gurlo, T.2    Costes, S.3    Huang, C.-J.4    Butler, P.C.5
  • 13
  • 15
    • 55549119209 scopus 로고    scopus 로고
    • Scaffolding function of PAK in the PDK1-Akt pathway
    • Higuchi M, Onishi K, Kikuchi C, Gotoh Y (2008). Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 10, 1356-1364.
    • (2008) Nat Cell Biol , vol.10 , pp. 1356-1364
    • Higuchi, M.1    Onishi, K.2    Kikuchi, C.3    Gotoh, Y.4
  • 19
    • 77952048131 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits
    • Jiang X, Chen S, Asara JM, Balk SP (2010). Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits. J Biol Chem 285, 14980-14989.
    • (2010) J Biol Chem , vol.285 , pp. 14980-14989
    • Jiang, X.1    Chen, S.2    Asara, J.M.3    Balk, S.P.4
  • 20
    • 34347255773 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: Clinical implications for the nervous system response to glucocorticoids and stress
    • Kino T, Ichijo T, Amin ND, Kesavapany S, Wang Y, Kim N, Rao S, Player A, Zheng Y-L, Garabedian MJ, et al. (2007). Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress. Mol Endocrinol 21, 1552-1568.
    • (2007) Mol Endocrinol , vol.21 , pp. 1552-1568
    • Kino, T.1    Ichijo, T.2    Amin, N.D.3    Kesavapany, S.4    Wang, Y.5    Kim, N.6    Rao, S.7    Player, A.8    Zheng, Y.-L.9    Garabedian, M.J.10
  • 22
    • 84869486602 scopus 로고    scopus 로고
    • Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients
    • Levacque Z, Rosales JL, Lee K-Y (2012). Level of cdk5 expression predicts the survival of relapsed multiple myeloma patients. Cell Cycle 11, 4093-4095.
    • (2012) Cell Cycle , vol.11 , pp. 4093-4095
    • Levacque, Z.1    Rosales, J.L.2    Lee, K.-Y.3
  • 23
    • 0042817922 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    • Li B-S, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, Pant HC (2003). Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278, 35702-35709.
    • (2003) J Biol Chem , vol.278 , pp. 35702-35709
    • Li, B.-S.1    Ma, W.2    Jaffe, H.3    Zheng, Y.4    Takahashi, S.5    Zhang, L.6    Kulkarni, A.B.7    Pant, H.C.8
  • 24
    • 84886929234 scopus 로고    scopus 로고
    • CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
    • Liang Q, Li L, Zhang J, Lei Y, Wang L, Liu D-X, Feng J, Hou P, Yao R, Zhang Y, et al. (2013). CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep 3, 2932.
    • (2013) Sci Rep , vol.3 , pp. 2932
    • Liang, Q.1    Li, L.2    Zhang, J.3    Lei, Y.4    Wang, L.5    Liu, D.-X.6    Feng, J.7    Hou, P.8    Yao, R.9    Zhang, Y.10
  • 25
    • 80051474950 scopus 로고    scopus 로고
    • Twice switched at birth: Cell cycle-independent roles of the "neuron-specific" cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells
    • Liebl J, Fürst R, Vollmar AM, Zahler S (2011). Twice switched at birth: cell cycle-independent roles of the "neuron-specific" cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells. Cell Signal 23, 1698-1707.
    • (2011) Cell Signal , vol.23 , pp. 1698-1707
    • Liebl, J.1    Fürst, R.2    Vollmar, A.M.3    Zahler, S.4
  • 26
    • 3142689920 scopus 로고    scopus 로고
    • Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis
    • Lin H, Juang J-L, Wang PS (2004). Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. J Biol Chem 279, 29302-29307.
    • (2004) J Biol Chem , vol.279 , pp. 29302-29307
    • Lin, H.1    Juang, J.-L.2    Wang, P.S.3
  • 27
    • 44949249877 scopus 로고    scopus 로고
    • Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
    • Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z (2008). Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. Proc Natl Acad Sci USA 105, 7570-7575.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7570-7575
    • Liu, R.1    Tian, B.2    Gearing, M.3    Hunter, S.4    Ye, K.5    Mao, Z.6
  • 28
    • 62549100016 scopus 로고    scopus 로고
    • Targeted therapy for advanced prostate cancer: Inhibition of the PI3K/Akt/mTOR pathway
    • Morgan TM, Koreckij TD, Corey E (2009). Targeted therapy for advanced prostate cancer: inhibition of the PI3K/Akt/mTOR pathway. Curr Cancer Drug Targets 9, 237-249.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 237-249
    • Morgan, T.M.1    Koreckij, T.D.2    Corey, E.3
  • 31
    • 78149352604 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis
    • Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ (2010). Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis. J Exp Med 207, 2507-2519.
    • (2010) J Exp Med , vol.207 , pp. 2507-2519
    • Pareek, T.K.1    Lam, E.2    Zheng, X.3    Askew, D.4    Kulkarni, A.B.5    Chance, M.R.6    Huang, A.Y.7    Cooke, K.R.8    Letterio, J.J.9
  • 33
    • 84868676813 scopus 로고    scopus 로고
    • Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus
    • Rytinki M, Kaikkonen S, Sutinen P, Paakinaho V, Rahkama V, Palvimo JJ (2012). Dynamic SUMOylation is linked to the activity cycles of androgen receptor in the cell nucleus. Mol Cell Biol 32, 4195-4205.
    • (2012) Mol Cell Biol , vol.32 , pp. 4195-4205
    • Rytinki, M.1    Kaikkonen, S.2    Sutinen, P.3    Paakinaho, V.4    Rahkama, V.5    Palvimo, J.J.6
  • 35
    • 33747875152 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
    • Strock CJ, Park J-I, Nakakura EK, Bova GS, Isaacs JT, Ball DW, Nelkin BD (2006). Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells. Cancer Res 66, 7509-7515.
    • (2006) Cancer Res , vol.66 , pp. 7509-7515
    • Strock, C.J.1    Park, J.-I.2    Nakakura, E.K.3    Bova, G.S.4    Isaacs, J.T.5    Ball, D.W.6    Nelkin, B.D.7
  • 36
    • 84905568509 scopus 로고    scopus 로고
    • SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner
    • Sutinen P, Malinen M, Heikkinen S, Palvimo JJ (2014). SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner. Nucleic Acids Res 42, 8310-8319.
    • (2014) Nucleic Acids Res , vol.42 , pp. 8310-8319
    • Sutinen, P.1    Malinen, M.2    Heikkinen, S.3    Palvimo, J.J.4
  • 37
  • 39
    • 84887499254 scopus 로고    scopus 로고
    • Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo
    • Thomas C, Lamoureux F, Crafter C, Davies BR, Beraldi E, Fazli L, Kim S, Thaper D, Gleave ME, Zoubeidi A (2013). Synergistic targeting of PI3K/AKT pathway and androgen receptor axis significantly delays castration-resistant prostate cancer progression in vivo. Mol Cancer Ther 12, 2342-2355.
    • (2013) Mol Cancer Ther , vol.12 , pp. 2342-2355
    • Thomas, C.1    Lamoureux, F.2    Crafter, C.3    Davies, B.R.4    Beraldi, E.5    Fazli, L.6    Kim, S.7    Thaper, D.8    Gleave, M.E.9    Zoubeidi, A.10
  • 42
    • 33646739524 scopus 로고    scopus 로고
    • Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor
    • Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON (2006). Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci USA 103, 7789-7794.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7789-7794
    • Xin, L.1    Teitell, M.A.2    Lawson, D.A.3    Kwon, A.4    Mellinghoff, I.K.5    Witte, O.N.6
  • 43
    • 33747842237 scopus 로고    scopus 로고
    • Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias
    • Yoshimoto M, Cutz J-C, Nuin PAS, Joshua AM, Bayani J, Evans AJ, Zielenska M, Squire JA (2006). Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias. Cancer Genet Cytogenet 169, 128-137.
    • (2006) Cancer Genet Cytogenet , vol.169 , pp. 128-137
    • Yoshimoto, M.1    Cutz, J.-C.2    Nuin, P.A.S.3    Joshua, A.M.4    Bayani, J.5    Evans, A.J.6    Zielenska, M.7    Squire, J.A.8
  • 44
    • 77950962922 scopus 로고    scopus 로고
    • Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex
    • Zhang J, Li H, Yabut O, Fitzpatrick H, D'Arcangelo G, Herrup K (2010). Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci 30, 5219-5228.
    • (2010) J Neurosci , vol.30 , pp. 5219-5228
    • Zhang, J.1    Li, H.2    Yabut, O.3    Fitzpatrick, H.4    D'Arcangelo, G.5    Herrup, K.6
  • 45
    • 84864392483 scopus 로고    scopus 로고
    • Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase
    • Zhang J, Li H, Zhou T, Zhou J, Herrup K (2012). Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem 287, 25985-25994.
    • (2012) J Biol Chem , vol.287 , pp. 25985-25994
    • Zhang, J.1    Li, H.2    Zhou, T.3    Zhou, J.4    Herrup, K.5
  • 46
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC (2001). HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3, 973-982.
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6


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