3,3′-diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions

International Journal of Molecular Medicine

Volumn 36, Issue 1, 2015, Pages 301-308

  Park, Hongzoo ^a   Lee, Dae Sung ^b   Yim, Mi Jin ^b   Choi, Yung Hyun ^c   Park, Saegwang ^d   Seo, Su Kil ^d   Choi, Jung Sik ^d   Jang, Won Hee ^d   Yea, Sung Su ^d   Park, Won Sun ^a   Lee, Chang Min ^e   Jung, Won Kyo ^a,f   Choi, Il Whan ^d  

^a Kangwon National University College of Medicine   (South Korea)

^b Marine Biodiversity Institute of Korea   (South Korea)

^c Dong Eui University   (South Korea)

^d Inje University   (South Korea)

^e BROWN UNIVERSITY   (United States)

^f Pukyong National University   (South Korea)

Author keywords

3,3 diindolylmethane; Age related macular degeneration; Choroidal neovascularization; Hypoxia; Retinal pigment epithelial cells; Vascular endothelial growth factor

Indexed keywords

3,3' DIINDOLYLMETHANE; COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VASCULOTROPIN; YCG 063; 3,3'-DIINDOLYLMETHANE; ANTINEOPLASTIC AGENT; COBALT; HIF1A PROTEIN, HUMAN; HYDRAZONE DERIVATIVE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITROIMIDAZOLE DERIVATIVE; SMALL INTERFERING RNA; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ARTICLE; ATTENUATION; CELL HYPOXIA; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ANALYSIS; GENE REPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MITOCHONDRION; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; RETINA CELL; RETINAL PIGMENT EPITHELIAL CELL; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; MACULAR DEGENERATION; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PIGMENT EPITHELIUM; PROTEIN TRANSPORT; RNA INTERFERENCE;

ANTICARCINOGENIC AGENTS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; COBALT; HUMANS; HYDRAZONES; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INDOLES; MACULAR DEGENERATION; MITOCHONDRIA; NF-KAPPA B; NITROIMIDAZOLES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; RNA INTERFERENCE; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84930371599     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2202     Document Type: Article

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