Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells

Clinical and Experimental Pharmacology and Physiology

Volumn 42, Issue 6, 2015, Pages 632-639

  Sung, Li Chin ^a   Chao, Hung Hsing ^b,c   Chen, Cheng Hsien ^c   Tsai, Jen Chen ^c   Liu, Ju Chi ^a   Hong, Hong Jye ^d   Cheng, Tzu Hurng ^e   Chen, Jin Jer ^f,g  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Endothelial cells; Endothelin 1; Heme oxygenase 1; Lycopene; Reactive oxygen species; Strain

Indexed keywords

ENDOTHELIN 1; GLUTATHIONE REDUCTASE; HEME OXYGENASE 1; LYCOPENE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P22; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; CAROTENOID; HMOX1 PROTEIN, HUMAN;

ARTICLE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; MECHANICAL STRESS; METABOLISM; PHYSIOLOGY;

CAROTENOIDS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; REACTIVE OXYGEN SPECIES; STRESS, MECHANICAL;

EID: 84930359929     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12412     Document Type: Article

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