Assembly mechanisms of specialized core particles of the proteasome

Biomolecules

Volumn 4, Issue 3, 2014, Pages 662-677

  Bai, Minghui ^a   Zhao, Xian ^a   Sahara, Kazutaka ^a   Ohte, Yuki ^a   Hirano, Yuko ^a   Kaneko, Takeumi ^a   Yashiroda, Hideki ^a   Murata, Shigeo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Assembly; Chaperone; Immunoproteasome; PAC1 PAC2; PAC3 PAC4; Propeptide; Proteasome; Thymoproteasome; UMP1

Indexed keywords

CHAPERONE; GAMMA INTERFERON; PROTEASOME; PROTEIN SUBUNIT; SMALL INTERFERING RNA;

ARTICLE; BIOGENESIS; CD8+ T LYMPHOCYTE; CELL CULTURE; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPATHOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; PLASMID; POLYMERASE CHAIN REACTION; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN STRUCTURE; RNA INTERFERENCE; ANTIBODY SPECIFICITY; CHEMISTRY; DEFICIENCY; ENZYMOLOGY; GENE SILENCING; GENETICS; HELA CELL LINE; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SUBUNIT; THYMUS;

GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MOLECULAR CHAPERONES; ORGAN SPECIFICITY; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; RNA, SMALL INTERFERING; THYMUS GLAND;

EID: 84930352736     PISSN: None     EISSN: 2218273X     Source Type: Journal    
DOI: 10.3390/biom4030662     Document Type: Article

References (29)

1. Baumeister, W.; Walz, J.; Zuhl, F.; Seemuller, E. The proteasome: Paradigm of a self-compartmentalizing protease. Cell 1998, 92, 367-380.
2. Glickman, M.H.; Ciechanover, A. The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol. Rev. 2002, 82, 373-428.
3. Köhler, A.; Cascio, P.; Leggett, D.S.; Woo, K.M.; Goldberg, A.L.; Finley, D. The axial channel of the proteasome core particle is gated by the Rpt2 atpase and controls both substrate entry and product release. Mol. Cell. 2001, 7, 1143-1152.
4. Groll, M.; Ditzel, L.; Löwe, J.; Stock, D.; Bochtler, M.; Bartunik, H.D.; Huber, R. Structure of 20S proteasome from yeast at 2.4 Å resolution. Nature 1997, 386, 463-471.
5. Unno, M.; Mizushima, T.; Morimoto, Y.; Tomisugi, Y.; Tanaka, K.; Yasuoka, N.; Tsukihara, T. The structure of the mammalian 20S proteasome at 2.75 Å resolution. Structure 2002, 10, 609-618.
6. Heinemeyer, W.; Fischer, M.; Krimmer, T.; Stachon, U.; Wolf, D.H. The active sites of the eukaryotic 20S proteasome and their involvement in subunit precursor processing. J. Biol. Chem. 1997, 272, 25200-25209.
7. Bar-Nun, S.; Glickman, M.H. Proteasomal AAA-ATPases: Structure and function. Biochim. Biophys. Acta 2012, 1823, 67-82.
8. Murata, S.; Yashiroda, H.; Tanaka, K. Molecular mechanisms of proteasome assembly. Nat. Rev. Mol. Cell. Biol. 2009, 10, 104-115.
9. Frentzel, S.; Pesold-Hurt, B.; Seelig, A.; Kloetzel, P.M. 20S proteasomes are assembled via distinct precursor complexes. Processing of LMP2 and LMP7 proproteins takes place in 13-16 S preproteasome complexes. J. Mol. Biol. 1994, 236, 975-981.
10. Nandi, D.; Woodward, E.; Ginsburg, D.B.; Monaco, J.J. Intermediates in the formation of mouse 20S proteasomes: Implications for the assembly of precursor beta subunits. EMBO J. 1997, 16, 5363-5375.
11. Hirano, Y.; Hendil, K.B.; Yashiroda, H.; Iemura, S.; Nagane, R.; Hioki, Y.; Natsume, T.; Tanaka, K.; Murata, S. A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature 2005, 437, 1381-1385.
12. Hirano, Y.; Hayashi, H.; Iemura, S.; Hendil, K.B.; Niwa, S.; Kishimoto, T.; Kasahara, M.; Natsume, T.; Tanaka, K.; Murata, S. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Mol. Cell. 2006, 24, 977-984.
13. Murata, S. Multiple chaperone-assisted formation of mammalian 20S proteasomes. IUBMB Life 2006, 58, 344-348.
14. Li, X.; Kusmierczyk, A.R.; Wong, P.; Emili, A.; Hochstrasser, M. Beta-subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J. 2007, 26, 2339-2349.
15. Le Tallec, B.; Barrault, M.B.; Courbeyrette, R.; Guérois, R.; Marsolier-Kergoat, M.C.; Peyroche, A. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol. Cell. 2007, 27, 660-674.
16. Yashiroda, H.; Mizushima, T.; Okamoto, K.; Kameyama, T.; Hayashi, H.; Kishimoto, T.; Niwa, S.; Kasahara, M.; Kurimoto, E.; Sakata, E.; et al. Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat. Struct. Mol. Biol. 2008, 15, 228-236.
17. Kusmierczyk, A.R.; Kunjappu, M.J.; Funakoshi, M.; Hochstrasser, M. A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat. Struct. Mol. Biol. 2008, 15, 237-244.
18. Heinemeyer, W.; Ramos, P.C.; Dohmen, R.J. The ultimate nanoscale mincer: Assembly, structure and active sites of the 20S proteasome core. Cell. Mol. Life Sci. 2004, 61, 1562-1578.
19. Hirano, Y.; Kaneko, T.; Okamoto, K.; Bai, M.; Yashiroda, H.; Furuyama, K.; Kato, K.; Tanaka, K.; Murata, S. Dissecting beta-ring assembly pathway of the mammalian 20S proteasome. EMBO J. 2008, 27, 2204-2213.
20. Ramos, P.C.; Marques, A.J.; London, M.K.; Dohmen, R.J. Role of C-terminal extensions of subunits beta2 and beta7 in assembly and activity of eukaryotic proteasomes. J. Biol. Chem. 2004, 279, 14323-14330.
21. Ramos, P.C.; Hockendorff, J.; Johnson, E.S.; Varshavsky, A.; Dohmen, R.J. Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 1998, 92, 489-499.
22. Tanaka, K.; Kasahara, M. The MHC class I ligand-generating system: Roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol. Rev. 1998, 163, 161-176.
23. + T cell development by thymus-specific proteasomes. Science 2007, 316, 1349-1353.
24. Seifert, U.; Bialy, L.P.; Ebstein, F.; Bech-Otschir, D.; Voigt, A.; Schröter, F.; Prozorovski, T.; Lange, N.; Steffen, J.; Rieger, M.; et al. Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 2010, 142, 613-624.
25. Murata, S.; Takahama, Y.; Tanaka, K. Thymoproteasome: Probable role in generating positively selecting peptides. Curr. Opin. Immunol. 2008, 20, 192-196.
26. Chen, P.; Hochstrasser, M. Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly. Cell 1996, 86, 961-972.
27. Griffin, T.A.; Nandi, D.; Cruz, M.; Fehling, H.J.; Kaer, L.V.; Monaco, J.J.; Colbert, R.A. Immunoproteasome assembly: Cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J. Exp. Med. 1998, 187, 97-104.
28. Nil, A.; Firat, E.; Sobek, V.; Eichmann, K.; Niedermann, G. Expression of housekeeping and immunoproteasome subunit genes is differentially regulated in positively and negatively selecting thymic stroma subsets. Eur. J. Immunol. 2004, 34, 2681-2689.
29. Chondrogianni, N.; Tzavelas, C.; Pemberton, A.J.; Nezis, I.P.; Rivett, A.J.; Gonos, E.S. Overexpression of proteasome beta5 assembled subunit increases the amount of proteasome and confers ameliorated response to oxidative stress and higher survival rates. J. Biol. Chem. 2005, 280, 11840-11850.