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Volumn 25, Issue 3, 2015, Pages 176-183

Genotoxicity and cytotoxicity of ZnO and Al2O3 nanoparticles

Author keywords

DNA repair; Oxidative DNA damage; Single and double strand breaks

Indexed keywords

ALUMINUM OXIDE; LIPOCORTIN 5; NANOPARTICLE; ZINC OXIDE NANOPARTICLE; METAL NANOPARTICLE; ZINC OXIDE;

EID: 84930246892     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2015.1006509     Document Type: Article
Times cited : (44)

References (32)
  • 1
    • 84862330295 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species
    • Akhtar MJ, Ahamed M, Kumar S, et al. (2012). Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species. Int J Nanomedicine 7:845-57.
    • (2012) Int J Nanomedicine , vol.7 , pp. 845-857
    • Akhtar, M.J.1    Ahamed, M.2    Kumar, S.3
  • 2
    • 66749187866 scopus 로고    scopus 로고
    • In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test
    • Balasubramanyam WX, Sailaja N, Mahboob M, et al. (2009). In vivo genotoxicity assessment of aluminium oxide nanomaterials in rat peripheral blood cells using the comet assay and micronucleus test. Mutagenesis 24:245-51.
    • (2009) Mutagenesis , vol.24 , pp. 245-251
    • Balasubramanyam, W.X.1    Sailaja, N.2    Mahboob, M.3
  • 3
    • 84907272472 scopus 로고    scopus 로고
    • Metabolomic analysis on the toxicological effects of TiO2 nanoparticles in mouse fibroblast cells: From the perspective of perturbations in amino acid metabolism
    • Bo Y, Jin C, Liu Y, et al. (2014). Metabolomic analysis on the toxicological effects of TiO2 nanoparticles in mouse fibroblast cells: from the perspective of perturbations in amino acid metabolism. Toxicol Mech Methods 24:461-9.
    • (2014) Toxicol Mech Methods , vol.24 , pp. 461-469
    • Bo, Y.1    Jin, C.2    Liu, Y.3
  • 4
    • 1642500474 scopus 로고    scopus 로고
    • Calcium and ROSmediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles
    • Brown DM, Donaldson K, Borm PJ, et al. (2004). Calcium and ROSmediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol 286:344-53.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286 , pp. 344-353
    • Brown, D.M.1    Donaldson, K.2    Borm, P.J.3
  • 5
    • 84862988627 scopus 로고    scopus 로고
    • Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells
    • Chiang HM, Xia Q, Zou X, et al. (2012). Nanoscale ZnO induces cytotoxicity and DNA damage in human cell lines and rat primary neuronal cells. J Nanosci Nanotechnol 12:2126-35.
    • (2012) J Nanosci Nanotechnol , vol.12 , pp. 2126-2135
    • Chiang, H.M.1    Xia, Q.2    Zou, X.3
  • 6
    • 77956885789 scopus 로고    scopus 로고
    • Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells
    • De Berardis B, Civitelli G, Condello M, et al. (2010). Exposure to ZnO nanoparticles induces oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol Appl Pharmacol 246:116-27.
    • (2010) Toxicol Appl Pharmacol , vol.246 , pp. 116-127
    • De Berardis, B.1    Civitelli, G.2    Condello, M.3
  • 7
    • 84887840004 scopus 로고    scopus 로고
    • Determination of TiO2, ZrO2, and Al2O3 nanoparticles on genotoxic responses in human peripheral blood lymphocytes and cultured embyronic kidney cells
    • Demir E, Burgucu D, Turna F, et al. (2013). Determination of TiO2, ZrO2, and Al2O3 nanoparticles on genotoxic responses in human peripheral blood lymphocytes and cultured embyronic kidney cells. J Toxicol Environ Health A 76:990-1002.
    • (2013) J Toxicol Environ Health A , vol.76 , pp. 990-1002
    • Demir, E.1    Burgucu, D.2    Turna, F.3
  • 8
    • 33746505396 scopus 로고    scopus 로고
    • Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells
    • Dufour EK, Kumaravel T, Nohynek GJ, et al. (2006). Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutat Res 607:215-24.
    • (2006) Mutat Res , vol.607 , pp. 215-224
    • Dufour, E.K.1    Kumaravel, T.2    Nohynek, G.J.3
  • 9
    • 67349174323 scopus 로고    scopus 로고
    • The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes
    • Gopalan RC, Osman IF, Amani A, et al. (2009). The effect of zinc oxide and titanium dioxide nanoparticles in the comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3: 33-9.
    • (2009) Nanotoxicology , vol.3 , pp. 33-39
    • Gopalan, R.C.1    Osman, I.F.2    Amani, A.3
  • 10
    • 84876540801 scopus 로고    scopus 로고
    • Functional responses of human adipose tissue-derived mesenchymal stem cells to metal oxide nanoparticles in vitro
    • Hackenberg S, Scherzed A, Technau A, et al. (2013). Functional responses of human adipose tissue-derived mesenchymal stem cells to metal oxide nanoparticles in vitro. J Biomed Nanotechnol 9:86-95.
    • (2013) J Biomed Nanotechnol , vol.9 , pp. 86-95
    • Hackenberg, S.1    Scherzed, A.2    Technau, A.3
  • 11
    • 77957871283 scopus 로고    scopus 로고
    • The comet assay in nanotoxicology research
    • Karlsson HL. (2010). The comet assay in nanotoxicology research. Anal Bioanal Chem 399:651-66.
    • (2010) Anal Bioanal Chem , vol.399 , pp. 651-666
    • Karlsson, H.L.1
  • 12
    • 0030580947 scopus 로고    scopus 로고
    • The comet assay: Mechanisms and technical considerations
    • Klaude M, Eriksson S, Nygren J, Ahnström G. (1996). The comet assay: mechanisms and technical considerations. Mutat Res 12:89-96.
    • (1996) Mutat Res , vol.12 , pp. 89-96
    • Klaude, M.1    Eriksson, S.2    Nygren, J.3    Ahnström, G.4
  • 13
    • 84882749092 scopus 로고    scopus 로고
    • The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells
    • Moschini E, Gualtieri M, Colombo M, et al. (2013). The modality of cell-particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells. Toxicol Lett 222:102-16.
    • (2013) Toxicol Lett , vol.222 , pp. 102-116
    • Moschini, E.1    Gualtieri, M.2    Colombo, M.3
  • 14
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel NH, Xia T, Madler L, Li N. (2006). Toxic potential of materials at the nanolevel. Science 311:622-7.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, N.H.1    Xia, T.2    Madler, L.3    Li, N.4
  • 15
    • 78149303282 scopus 로고    scopus 로고
    • Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells
    • Osman IF, Baumgartner A, Cemeli E, et al. (2010). Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells. Nanomedicine (Lond) 5:1193-203.
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 1193-1203
    • Osman, I.F.1    Baumgartner, A.2    Cemeli, E.3
  • 16
    • 82755182784 scopus 로고    scopus 로고
    • Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells
    • Radziun E, Dudkiewicz Wilczyńska J, Ksiaz-ek I, et al. (2011). Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells. Toxicol In Vitro 25:1694-700.
    • (2011) Toxicol in Vitro , vol.25 , pp. 1694-1700
    • Radziun, E.1    Dudkiewicz Wilczyńska, J.2    Ksiazek, I.3
  • 17
    • 34249653611 scopus 로고    scopus 로고
    • Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems
    • Reddy KM, Feris K, Bell J, et al. (2007). Selective toxicity of zinc oxide nanoparticles to prokaryotic and eukaryotic systems. Appl Phys Lett 90:2139021-23.
    • (2007) Appl Phys Lett , vol.90 , pp. 2139021-2139023
    • Reddy, K.M.1    Feris, K.2    Bell, J.3
  • 18
    • 84896911789 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition
    • Roy R, Singh SK, Chauhan LK, et al. (2014). Zinc oxide nanoparticles induce apoptosis by enhancement of autophagy via PI3K/Akt/mTOR inhibition. Toxicol Lett 227:29-40.
    • (2014) Toxicol Lett , vol.227 , pp. 29-40
    • Roy, R.1    Singh, S.K.2    Chauhan, L.K.3
  • 19
    • 84865129488 scopus 로고    scopus 로고
    • Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)
    • Sharma V, Anderson D, Dhawan A. (2012a). Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2). Apoptosis 17: 852-70.
    • (2012) Apoptosis , vol.17 , pp. 852-870
    • Sharma, V.1    Anderson, D.2    Dhawan, A.3
  • 20
    • 60349122749 scopus 로고    scopus 로고
    • DNA damaging potential of zinc oxide nanoparticles in human epidermal cells
    • Sharma V, Shukla RK, Saxena N, et al. (2009). DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol Lett 185:211-18.
    • (2009) Toxicol Lett , vol.185 , pp. 211-218
    • Sharma, V.1    Shukla, R.K.2    Saxena, N.3
  • 21
    • 84860432043 scopus 로고    scopus 로고
    • Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles
    • Sharma V, Singh P, Pandey AK, Dhawan A. (2012b). Induction of oxidative stress, DNA damage and apoptosis in mouse liver after sub-acute oral exposure to zinc oxide nanoparticles. Mutat Res 745: 84-91.
    • (2012) Mutat Res , vol.745 , pp. 84-91
    • Sharma, V.1    Singh, P.2    Pandey, A.K.3    Dhawan, A.4
  • 22
    • 0023919963 scopus 로고
    • A simple technique for quantification of low levels of DNA damage in individual cells
    • Singh NP, McCoy MT, Tice RR, Schneider EL. (1988). A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184-91.
    • (1988) Exp Cell Res , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 23
    • 84877816890 scopus 로고    scopus 로고
    • Effect of zinc oxide nanoparticles on cellular oxidative stress and antioxidant defense mechanisms in mouse liver
    • Syama S, Reshma SC, Sreekanth PJ, et al. (2013). Effect of zinc oxide nanoparticles on cellular oxidative stress and antioxidant defense mechanisms in mouse liver. Toxicol Environ Chem 95: 495-503.
    • (2013) Toxicol Environ Chem , vol.95 , pp. 495-503
    • Syama, S.1    Reshma, S.C.2    Sreekanth, P.J.3
  • 24
    • 0034037611 scopus 로고    scopus 로고
    • Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing
    • Tice RR, Agurell E, Anderson D, et al. (2000). Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35:206-21.
    • (2000) Environ Mol Mutagen , vol.35 , pp. 206-221
    • Tice, R.R.1    Agurell, E.2    Anderson, D.3
  • 25
    • 84858667266 scopus 로고    scopus 로고
    • Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells
    • Tice RR, Agurell E, Anderson D, et al. (2012). Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells. Chem Res Toxicol 25:646-55.
    • (2012) Chem Res Toxicol , vol.25 , pp. 646-655
    • Tice, R.R.1    Agurell, E.2    Anderson, D.3
  • 26
    • 84876295645 scopus 로고    scopus 로고
    • In vitro cytotoxicity and in vivo osseointergration properties of compression-molded HDPEHA-Al2O32 hybrid biocomposites
    • Tripathi G, Gough JE, Dinda A, Basu B. (2013). In vitro cytotoxicity and in vivo osseointergration properties of compression-molded HDPEHA-Al2O32 hybrid biocomposites. J Biomed Mater Res A 101: 1539-49.
    • (2013) J Biomed Mater Res A , vol.101 , pp. 1539-1549
    • Tripathi, G.1    Gough, J.E.2    Dinda, A.3    Basu, B.4
  • 27
    • 79955846142 scopus 로고    scopus 로고
    • Fabrication and growth mechanism of ZnO nanostructures and their cytotoxic effect on human brain tumor U87, cervical cancer HeLa, and normal HEK cells
    • Wahab R, Kaushik NK, Verma AK, et al. (2011). Fabrication and growth mechanism of ZnO nanostructures and their cytotoxic effect on human brain tumor U87, cervical cancer HeLa, and normal HEK cells. J Biol Inorg Chem 16:431-42.
    • (2011) J Biol Inorg Chem , vol.16 , pp. 431-442
    • Wahab, R.1    Kaushik, N.K.2    Verma, A.K.3
  • 28
    • 33846131928 scopus 로고    scopus 로고
    • Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration
    • Wang J, Zhou G, Chen C, et al. (2007). Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176-85.
    • (2007) Toxicol Lett , vol.168 , pp. 176-185
    • Wang, J.1    Zhou, G.2    Chen, C.3
  • 29
    • 80053333608 scopus 로고    scopus 로고
    • A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells
    • Wang Y, Aker WG, Hwang HM, et al. (2011). A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ 409: 4753-62.
    • (2011) Sci Total Environ , vol.409 , pp. 4753-4762
    • Wang, Y.1    Aker, W.G.2    Hwang, H.M.3
  • 30
    • 79951813476 scopus 로고    scopus 로고
    • Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: Acute toxicity, oxidative stress and oxidative damage
    • Xiong D, Fang T, Yu L, et al. (2011). Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ 409:1444-52.
    • (2011) Sci Total Environ , vol.409 , pp. 1444-1452
    • Xiong, D.1    Fang, T.2    Yu, L.3
  • 31
    • 58149475510 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: The role of particle size, shape and composition
    • Yang H, Liu C, Yang D, et al. (2009). Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition. J Appl Toxicol 29:69-78.
    • (2009) J Appl Toxicol , vol.29 , pp. 69-78
    • Yang, H.1    Liu, C.2    Yang, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.