Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 4, 2015, Pages 973-980

  Paloschi, Valentina ^a   Gådin, Jesper R ^a   Khan, Shaukat ^c   Björck, Hanna M ^a   Du, Lei ^a   Maleki, Shohreh ^a   Roy, Joy ^b   Lindeman, Jan H M ^d   Mohamed, Salah A ^e   Tsuda, Takeshi ^c   Franco Cereceda, Anders ^b   Eriksson, Per ^a  

^a Center for Molecular Medicine   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NEMOURS ALFRED I DUPONT HOSPITAL FOR CHILDREN   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

aneurysm; bicuspid aortic valve

Indexed keywords

LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 2; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 3; LATENT TRANSFORMING GROWTH FACTOR BETA BINDING PROTEIN 4; MESSENGER RNA; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; LTBP3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANGIOGENESIS; ARTICLE; BICUSPID AORTIC VALVE; CELL CULTURE; CELL ISOLATION; CELL MIGRATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FOCAL ADHESION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SIGNAL TRANSDUCTION; THORACIC AORTA ANEURYSM; TRANSCRIPTION INITIATION; ADULT; AGED; AORTA VALVE; AORTIC ANEURYSM; COMPLICATION; CONGENITAL MALFORMATION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; PROCEDURES; VALVULAR HEART DISEASE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AORTIC ANEURYSM; AORTIC VALVE; CELLS, CULTURED; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART VALVE DISEASES; HUMANS; LATENT TGF-BETA BINDING PROTEINS; MALE; MIDDLE AGED; PHOSPHORYLATION; PRINCIPAL COMPONENT ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84930243298     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304996     Document Type: Article

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