Synthesis and evaluation of anticonvulsant and antidepressant activities of 7-alkyl-7H-tetrazolo[1,5-g]purine derivatives

Medicinal Chemistry Research

Volumn 23, Issue 10, 2014, Pages 4619-4626

  Wang, Shi Ben ^a   Deng, Xian Qing ^b   Liu, Da Chuan ^a   Zhang, Hong Jian ^a   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b JINGGANGSHAN UNIVERSITY   (China)

Author keywords

Anticonvulsant; Antidepressant; Forced swimming test; Maximal electroshock test; PTZ; Tetrazole

Indexed keywords

4 AMINOBUTYRIC ACID; 7 ( 3 FLUOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (2 BENZONITRILE) 7H TETRAZOLO[1,5 G]PURINE; 7 (2 CHLOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (2 FLUOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (2,4 DICHLOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (2,6 DICHLOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (3 CHLOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 BENZONITRILE) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 CHLOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 FLUOROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 METHOXYBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 METHYLBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 (4 NITROBENZYL) 7H TETRAZOLO[1,5 G]PURINE; 7 BENZYL 7H TETRAZOLO[1,5 G]PURINE; 7 HEPTYL 7H TETRAZOLO[1,5 G]PURINE; 7 HEXYL 7H TETRAZOLO[1,5 G]PURINE; 7 OCTYL 7H TETRAZOLO[1,5 G]PURINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; FLUOXETINE; PENTETRAZOLE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANTIDEPRESSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; FORCED SWIM TEST; IMMOBILITY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PENTYLENETETRAZOLE-INDUCED SEIZURE;

EID: 84930231304     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-014-1030-0     Document Type: Article

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