Synthesis and evaluation on anticonvulsant and antidepressant activities of 5-alkoxy-tetrazolo[1,5-a]quinazolines

Archiv der Pharmazie

Volumn 342, Issue 11, 2009, Pages 671-675

  Wang, Huo Jian ^a,b   Wei, Cheng Xi ^b   Deng, Xian Qing ^b   Li, Fu Lan ^b   Quan, Zhe Shan ^a,b  

^a INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

^b YANBIAN UNIVERSITY   (China)

Author keywords

Anticonvulsant; Antidepressant; Forced swimming test; Quinazoline; Tetrazole

Indexed keywords

5 (2 CHLOROPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (2 METHOXYPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (2 TOLYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (2,4 DICHLOROPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (3 CHLOROPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (3 TOLYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (4 CHLOROPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (4 FLUOROPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (4 METHOXYPHENOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (4 TOLYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (DECYOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (HEPTYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (HEXYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (NONYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (OCTYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 (PENTYLOXY)TETRAZOLO[1,5 A]QUINAZOLINE; 5 BUTOXYTETRAZOLO[1,5 A]QUINAZOLINE; 5 ETHOXYTETRAZOLO[1,5 A]QUINAZOLINE; 5 ISOPROPOXYTETRAZOLO[1,5 A]QUINAZOLINE; 5 METHOXYTETRAZOLO[1,5 A]QUINAZOLINE; 5 PHENOXYTETRAZOLO[1,5 A]QUINAZOLINE; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; FLUOXETINE; MONOAMINE OXIDASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; FORCED SWIMMING TEST; IMMOBILIZATION; INFRARED RADIATION; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; MOLECULAR STRUCTURE; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70449380842     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900119     Document Type: Article

References (22)

1. Z. S. Quan, J. M. Wang, J. R. Rho, K. C. Kwak, et al., Bull. Korean. Chem. Soc. 2005, 26, 1757-1759.
2. X. Y. Sun, L. Zhang, C. X. Wei, H. R. Piao, Z. S. Quan, Eur. J. Med. Chem. 2009, 44, 1265-1270.
3. H. G. Jin, X. Y. Sun, K. Y. Chai, H. R. Piao, Z. S. Quan, Bioorg. Med. Chem. 2006, 14, 6868-6873.
4. X. Y. Sun, G. Li, C. S. Jun, K. Y. Chai, et al., Arch. Pharm. Res. 2006, 29, 1080-1085.
5. L. J. Guo, C. X. Wei, J. H. Jia, L. M. Zhao, Z. S. Quan, Eur. J. Med. Chem. 2009, 44, 954-958.
6. L. P. Guan, Q. H. Jin, S. F. Wang, F. N. Li, Z. S. Quan, Arch. Pharm. 2008, 341, 774-779.
7. L. P. Guan, G. R. Tian, K. Y. Chai, J. S. Lee , M. S. Song, Z. S. Quan, Turk. J. Chem. 2008, 32, 181-189.
8. Z. F. Xie, K. Y. Chai, H. R. Piao, C. K. Kyung, Z. S. Quan, Bioorg. Med. Chem. Lett. 2005, 15, 4803-4805.
9. L. J. Cui, Z. F. Xie, H. R. Piao, G. Li, et al., Biol. Pharm. Bull. 2005, 28, 1216-1220.
10. L. Zhang, L. P. Guan, X. Y. Sun, K. Y. Chai, Z. S. Quan, Chem. Biol. Drug Des. 2009, 73, 313-319.
11. G. Szymczyk, I. Zebrowska-Lupina, Pol. J. Pharmacol. 2000, 52, 337-344.
12. S. R. Joca, L. L. Skalisz, V. Beijamini, M. A. Vital, R. Andreatini, Eur. Neuropsychopharmacol. 2000, 10, 223-228.
13. S. Li, C. Wang, W. Li, K. Koike, et al., J. Asian Nat. Prod. Res. 2007, 9, 421-430.
14. M. P. Kaster, I. Raupp, R. W. Binfaré, R. Andreatini, A. L. Rodrigues, Eur. J. Pharmacol. 2007, 565, 119-124.
15. X. Y. Sun, L. Zhang, C. X. Wei, H. R. Piao, Z. S. Quan, Pharmacol. Rep. 2009, 61, 245-251.
16. A. A. Bekhit, O. A. El-Sayed, E. Aboulmagd, J. Y. Park, Eur. J. Med. Chem. 2004, 39, 249-255.
17. R. L. Krall, J. K. Penry, B. G. White, H. J. Kupferberg, E. A. Swinyard, Epilepsia 1978, 19, 409-412.
18. R. J. Porter, J. J. Cereghino, G. D. Gladding, B. J. Hessie, et al., Cleve. Clin. Q. 1984, 51, 293-295.
19. R. D. Porsolt, A. Bertin, M. Jalfre, Arch. Int. Pharmacodyn. Ther. 1977, 229, 327-336.
20. M. Bourin, M. Hascoet, M. C. Colombel, R. T. Coutts, G. B. Baker, J. Psychiatry Neurosci. 2002, 27, 178-185.
21. R. D. Porsolt, in Antidepressants: Neurochemical, Behavioral and Clinical Perspective (Eds.: S. J. Enna, J. B. Malick, E. Richelson), Raven Press, New York 1981, pp. 121-128.
22. P. Willner, P. J. Mitchell, Behav. Pharmacol. 2002, 13, 169-188.