Synthesis and primary anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine derivatives

Arzneimittel-Forschung/Drug Research

Volumn 60, Issue 6, 2010, Pages 289-292

  Sun, Xian Yu ^a   Wei, Cheng Xi ^b   Deng, Xian Qing ^a   Sun, Zhi Gang ^b   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

Author keywords

Antiepileptic drugs; Maximal electroshock; Phthalazine derivatives, anticonvulsant activity; Tetrazole

Indexed keywords

6 (4 CHLOROPHENYLOXYL)TETRAZOLO[5,1 A]PHTHALAZINE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; PHTHALAZINE DERIVATIVE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; NEUROTOXICITY; NONHUMAN; ROTAROD TEST; SEIZURE; ANIMAL; EPILEPSY; HUMAN; MOUSE; SEIZURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; EPILEPSY; HUMANS; MICE; PHTHALAZINES; ROTAROD PERFORMANCE TEST; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954587780     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296289     Document Type: Article

References (12)

1. Loscher W. New visions in the pharmacology of anticonvulsion. Eur J Pharmacol. 1998;342:1-13.
2. Leppik IE. Antiepileptic drugs in development: prospects for the near future. Epilepsia. 1994;35:S4,29-40.
3. Perucca E. The new generation of antiepileptic drugs: advantages and disadvantages. Br J Clin Pharmacol. 1996;42:531-43.
4. Lin Z, Kadaba PK. Molecular targets for the rational design of antiepileptic drugs and related neuroprotective agents. Med Res Rev. 1997;17:537-72.
5. Al-Soud YA, Al-Masoudi NA, Ferwanah A. Synthesis and properties of new substituted 1,2,4-triazoles: potential antitumor agents. Bioorg Med Chem. 2003;1:1701-8.
6. Sivakumar R, Kishore Gnanasam S, Ramachandran S, Leonard JT. Pharmacological evaluation of some new 1-substituted-4-hydroxy-phthalazines. Eur J Med Chem. 2002;37:793-801. (Pubitemid 35346539)
7. Krall RL, Penry JK, White BG, Kupferberg HJ, Swinyard EA. Antiepileptic drug development: II. Anticonvulsant drug screening. Epilepsia. 1978;19:409-28.
8. Porter RJ, Cereghino JJ, Gladding GD, Hessie BJ, Kupferberg HJ, Scoville B, et al. Antiepileptic Drug Development Program. Cleve Clin Q. 1984;51:293-305.
9. Hamilton MA, Russo RC, Thurston RC. Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Env Sci Technol. 1977;7:714-19.
10. Sun XY, Jin YZ., Li FN, Li G, Chai KY, Quan ZS. Synthesis of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-ones and evaluation of their anticonvulsant properties. Arch Pharm Res. 2006;29:1080-5.
11. John HMH, John HE. Nucleophilic Heteroaromatic Substitution. II. Phthalazines. J Org Chem. 1971;36:3248-51.
12. Chimirri A, Zappala M, Gitto R, Quartarone S, Bevacqua F. Synthesis and structural features of 1H-tetrazolo[1,5-c] [2,3]-benzodiazepines. Heterocycles. 1999;51:1303-9.