Synthesis and anticancer activity of (RS)-9-(2,3-dihydro-1,4- benzoxaheteroin-2-ylmethyl)-9H-purines

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3795-3801

  Conejo García, Ana ^a   García Rubiño, M Eugenia ^a   Marchal, Juan A ^b   Núñez, M Carmen ^a   Ramírez, Alberto ^b   Cimino, Sandro ^a   García, M Ángel ^b,c   Aránega, Antonia ^b   Gallo, Miguel A ^a   Campos, Joaquín M ^a  

^a Facultad de Farmacia   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

Author keywords

1,4 Benzodioxin; 1,4 Benzoxathiin; Apoptosis; Breast cancer cell line MCF 7; eIF2 ; Neighboring group participation; Purine

Indexed keywords

2,6 DICHLORO 9 (2,3 DIHYDRO 1,4 BENZODIOXIN 2 YLMETHYL) 9H PURINE; 2,6 DICHLORO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 2 YLMETHYL) 9H PURINE; 2,6 DICHLORO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 3 YLMETHYL) 9H PURINE; 6 AMINO 9 (2,3 DIHYDRO 1,4 BENZODIOXIN 2 YLMETHYL) 9H PURINE; 6 AMINO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 2 YLMETHYL) 9H PURINE; 6 BROMO 9 (2,3 DIHYDRO 1,4 BENZODIOXIN 2 YLMETHYL) 9H PURINE; 6 BROMO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 2 YLMETHYL) 9H PURINE; 6 BROMO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 3 YLMETHYL) 9H PURINE; 6 CHLORO 9 (2,3 DIHYDRO 1,4 BENZODIOXIN 2 YLMETHYL) 9H PURINE; 6 CHLORO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 2 YLMETHYL) 9H PURINE; 6 CHLORO 9 (2,3 DIHYDRO 1,4 BENZOXATHIIN 3 YLMETHYL) 9H PURINE; 9 (2,3 DIHYDRO 1,4 BENZOXAHETEROIN 2 YLMETHYL) 9H PURINE DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 9; INITIATION FACTOR 2ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROWAVE RADIATION; MITSUNOBU REACTION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PURINES;

EID: 80052932221     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.046     Document Type: Article

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