Physicochemical properties of tadalafil solid dispersions - Impact of polymer on the apparent solubility and dissolution rate of tadalafil

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 94, Issue , 2015, Pages 106-115

  Wlodarski, K ^a   Sawicki, W ^a   Haber, K ^a   Knapik, J ^b   Wojnarowska, Z ^b   Paluch, M ^b   Lepek, P ^c   Hawelek, L ^d   Tajber, L ^e  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b UNIVERSITY OF SILESIA   (Poland)

^c Pharmaceutical Works Polpharma SA   (Poland)

^d INSTITUTE OF NON FERROUS METALS   (Poland)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Amorphous drug; Apparent solubility; Dissolution rate; Freeze drying; Polymer; Solid dispersion; Supersaturation; Tadalafil

Indexed keywords

COPOLYMER; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL POLYVINYL ALCOHOL COPOLYMER; METHYLCELLULOSE; POLYMER; POVIDONE; TADALAFIL; UNCLASSIFIED DRUG; VINYLCAPROLACTAM MACROGOL VINYL ACETATE COPOLYMER; VINYLPYRROLIDONE VINYL ACETATE COPOLYMER; MICROCAPSULE; POLY(VINYLPYRROLIDONE-CO-VINYL-ACETATE); POWDER; PYRROLIDINE DERIVATIVE; VINYL DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG SOLUBILITY; EVAPORATION; FILM; FREEZE DRYING; HYDROGEN BOND; INFRARED SPECTROSCOPY; LYOPHILISATE; MICROCAPSULE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SOLID; THERMAL ANALYSIS; X RAY DIFFRACTION; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; KINETICS; MEDICINAL CHEMISTRY; PHARMACEUTICS; POWDER; POWDER DIFFRACTION; PROCEDURES; SOLUBILITY; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

CALORIMETRY, DIFFERENTIAL SCANNING; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; FREEZE DRYING; HYDROGEN BONDING; HYPROMELLOSE DERIVATIVES; KINETICS; MICROSCOPY, ELECTRON, SCANNING; POWDER DIFFRACTION; POWDERS; PYRROLIDINES; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TADALAFIL; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; VINYL COMPOUNDS;

EID: 84930211404     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.04.031     Document Type: Article

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