Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Kiss, Katalin ^a   Baghy, Kornélia ^a   Spisák, Sándor ^b   Szanyi, Szilárd ^a,c   Tulassay, Zsolt ^a   Zalatnai, Attila ^a   Löhr, J Matthias ^d   Jesenofsky, Ralf ^c   Kovalszky, Ilona ^a   Firneisz, Gábor ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE PHOSPHATASE; SOMATOMEDIN BINDING PROTEIN 2; STROMAL CELL DERIVED FACTOR 1; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1; CHEMOKINE RECEPTOR CXCR4; CONDITIONED MEDIUM; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC HYPERGLYCEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MOLECULAR DYNAMICS; PANCREAS CANCER; PANCREATIC STELLATE CELL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; CELL LINE; CONDITIONED MEDIUM; CYTOLOGY; DNA MICROARRAY; DRUG EFFECTS; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHARMACOLOGY; PROCEDURES;

CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMOKINE CXCL12; CULTURE MEDIA, CONDITIONED; GENE EXPRESSION PROFILING; HUMANS; HYPERGLYCEMIA; MAP KINASE SIGNALING SYSTEM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PANCREATIC NEOPLASMS; PANCREATIC STELLATE CELLS; RECEPTORS, CXCR4; UP-REGULATION;

EID: 84930208576     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128059     Document Type: Article

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