Kinetic Analysis and Quantification of [11C]Martinostat for in Vivo HDAC Imaging of the Brain

ACS Chemical Neuroscience

Volumn 6, Issue 5, 2015, Pages 708-715

  Wey, Hsiao Ying ^a   Wang, Changning ^a   Schroeder, Frederick A ^a   Logan, Jean ^b   Price, Julie C ^c   Hooker, Jacob M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Epigenetic regulation; histone deacetylases; kinetic model; occupancy; PET

Indexed keywords

HISTONE DEACETYLASE; MARTINOSTAT C 11; TRACER; UNCLASSIFIED DRUG; ADAMANTANE; CARBON; HYDROXAMIC ACID; MARTINOSTAT; RADIOPHARMACEUTICAL AGENT;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR CINGULATE; ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN MAPPING; CEREBELLUM; COMPARTMENT MODEL; CONTROLLED STUDY; DORSOLATERAL PREFRONTAL CORTEX; DOSE RESPONSE; DRUG BRAIN LEVEL; DRUG PENETRATION; FEMALE; HIPPOCAMPUS; IN VIVO STUDY; KINETICS; MALE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; ORBITAL CORTEX; OUTCOME ASSESSMENT; PAPIO ANUBIS; PET-MRI SCANNER; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUTAMEN; RADIOACTIVITY; STRIATE CORTEX; SUBCORTEX; SUPPLEMENTARY MOTOR AREA; THALAMUS; VISUAL CORTEX; VOLUME OF DISTRIBUTION; WHITE MATTER; ANALOGS AND DERIVATIVES; ANIMAL; BABOON; BRAIN; DIAGNOSTIC IMAGING; IMAGE PROCESSING; METABOLISM; PROCEDURES;

PRIMATES;

ADAMANTANE; ANIMALS; BRAIN; CARBON RADIOISOTOPES; FEMALE; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 84930198523     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00066     Document Type: Article

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